CRISPR/Cas9 gene editing and functional screening in chronic lymphocytic leukemia

PESCHELOVÁ, Helena, Veronika KOZLOVÁ, Václav HEJRET and Michal ŠMÍDA. CRISPR/Cas9 gene editing and functional screening in chronic lymphocytic leukemia. In Joint retreat 2019, Kouty u Ledče nad Sázavou. 2019. ISBN 978-80-210-9300-3.

Basic information

• Original name: CRISPR/Cas9 gene editing and functional screening in chronic lymphocytic leukemia
• Authors: PESCHELOVÁ, Helena (203 Czech Republic, belonging to the institution), Veronika KOZLOVÁ (203 Czech Republic, belonging to the institution), Václav HEJRET (203 Czech Republic, belonging to the institution) and Michal ŠMÍDA (203 Czech Republic, belonging to the institution).
• Edition: Joint retreat 2019, Kouty u Ledče nad Sázavou, 2019.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Field of Study: 30204 Oncology
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• RIV identification code: RIV/00216224:14740/19:00112812
• Organization unit: Central European Institute of Technology
• ISBN: 978-80-210-9300-3
• Keywords in English: CRISPR/Cas9; chronic lymphocytic leukemia
• Tags: rivok

Abstract

Chronic lymphocytic leukemia (CLL) patients carry a variety of somatic mutations, whose thorough exploration could shed light on the etiology of the disease, or even lead to the discovery of potential novel drug targets. However, as primary CLL cells do not proliferate in vitro, there is a lack of suitable models mimicking the genetic heterogeneity observed in patients. Our aim is to establish isogenic cell lines harboring the most frequent CLL mutations and to investigate unique vulnerabilities specific to these mutations.

Links

• LQ1601, research and development project: Name: CEITEC 2020 (Acronym: CEITEC2020)

Investor: Ministry of Education, Youth and Sports of the CR