CRISPR/Cas9 gene editing and functional screening in chronic lymphocytic leukemia

PESCHELOVÁ, Helena, Veronika KOZLOVÁ, Václav HEJRET and Michal ŠMÍDA. CRISPR/Cas9 gene editing and functional screening in chronic lymphocytic leukemia. In Joint retreat 2019, Kouty u Ledče nad Sázavou. 2019. ISBN 978-80-210-9300-3.

Basic information

Original name

CRISPR/Cas9 gene editing and functional screening in chronic lymphocytic leukemia

Authors

PESCHELOVÁ, Helena (203 Czech Republic, belonging to the institution), Veronika KOZLOVÁ (203 Czech Republic, belonging to the institution), Václav HEJRET (203 Czech Republic, belonging to the institution) and Michal ŠMÍDA (203 Czech Republic, belonging to the institution)

Edition

Joint retreat 2019, Kouty u Ledče nad Sázavou, 2019

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Other information

Language

English

Type of outcome

Konferenční abstrakt

Field of Study

30204 Oncology

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

RIV identification code

RIV/00216224:14740/19:00112812

Organization unit

Central European Institute of Technology

ISBN

978-80-210-9300-3

Keywords in English

CRISPR/Cas9; chronic lymphocytic leukemia

Tags

rivok

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Abstract

V originále

Chronic lymphocytic leukemia (CLL) patients carry a variety of somatic mutations, whose thorough exploration could shed light on the etiology of the disease, or even lead to the discovery of potential novel drug targets. However, as primary CLL cells do not proliferate in vitro, there is a lack of suitable models mimicking the genetic heterogeneity observed in patients. Our aim is to establish isogenic cell lines harboring the most frequent CLL mutations and to investigate unique vulnerabilities specific to these mutations.

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Links

LQ1601, research and development project

Name: CEITEC 2020 (Acronym: CEITEC2020) Investor: Ministry of Education, Youth and Sports of the CR