J 2019

Impact of Long-Term Lithium Treatment on Renal Function in Patients With Bipolar Disorder Based on Novel Biomarkers

DASTYCH, Milan, Oldřich SYNEK and Jana GOTTWALDOVÁ

Basic information

Original name

Impact of Long-Term Lithium Treatment on Renal Function in Patients With Bipolar Disorder Based on Novel Biomarkers

Authors

DASTYCH, Milan (203 Czech Republic, guarantor, belonging to the institution), Oldřich SYNEK (203 Czech Republic, belonging to the institution) and Jana GOTTWALDOVÁ (203 Czech Republic, belonging to the institution)

Edition

JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, PHILADELPHIA, LIPPINCOTT WILLIAMS & WILKINS, 2019, 0271-0749

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 2.700

RIV identification code

RIV/00216224:14110/19:00112814

Organization unit

Faculty of Medicine

DOI

UT WoS

000465946500009

Keywords in English

bipolar disorder; lithium treatment; glomerular filtration; chronic kidney disease

Tags

Tags

International impact, Reviewed
Změněno: 29/1/2020 10:37, Mgr. Tereza Miškechová

Abstract

V originále

Background Lithium in the form of lithium carbonate (Li2CO3) has become one of the most effective and widely prescribed drugs for mood stabilization. However, lithium has adverse effects on renal tubular functions, such as decreased concentrating function of the kidneys, and even occasional symptoms of nephrogenous diabetes insipidus occur with additional evidence of glomerular disruption in lithium-treated patients. Methods We assessed the kidney function of patients with bipolar disorder who are under long-term lithium treatment using novel markers of kidney damage such as plasma neutrophil gelatinase-associated lipocalin, cystatin C, albuminuria, estimated glomerular filtration rate, Chronic Kidney Disease-Epidemiology Investigation using creatinine and cystatin C, and serum and urinary osmolality, and compared the results with those of age-matched patients with bipolar disorder not treated with lithium. The study enrolled 120 patients with bipolar disorder, consisting of 80 (30 male and 50 female patients) who have been receiving lithium for 0.5 to 20 (mean, 7) years and 40 (10 male and 30 female patients) who had never been exposed to lithium treatment. Results Patients treated with lithium had significantly decreased urine osmolality (mean +/- SD, 405 +/- 164 vs 667 +/- 174 mmol/kg) and urine-to-serum osmolality ratio (1.35 +/- 0.61 vs 2.25 +/- 0.96). No significant difference was found in creatinine, estimated glomerular filtration rate values calculated using the Chronic Kidney Disease-Epidemiology Investigation using creatinine and cystatin C, neutrophil gelatinase-associated lipocalin, cystatin C, and albuminuria between both groups. We found no significant difference in renal biomarkers between patients treated with lithium for 6 to 24 months and those treated for 25 to 240 months. Conclusions We found significantly decreased kidney concentrating ability in the long-term lithium-treated patients compared with the control group. Other renal function markers did not indicate any significant signs of renal dysfunction.