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@article{1614340,
author = {Olbertová, Helena and Plevová, Karla and Stránská, Kamila and Pospíšilová, Šárka},
article_number = {1},
doi = {http://dx.doi.org/10.5507/bp.2018.084},
keywords = {telomere; telomerase; leukemia; lymphoma; hematooncology; aging},
language = {eng},
issn = {1213-8118},
journal = {Biomedical Papers},
title = {Telomere dynamics in adult hematological malignancies},
url = {https://biomed.papers.upol.cz/pdfs/bio/2019/01/01.pdf},
volume = {163},
year = {2019}
}
TY - JOUR
ID - 1614340
AU - Olbertová, Helena - Plevová, Karla - Stránská, Kamila - Pospíšilová, Šárka
PY - 2019
TI - Telomere dynamics in adult hematological malignancies
JF - Biomedical Papers
VL - 163
IS - 1
SP - 1-7
EP - 1-7
PB - Univerzita Palackého v Olomouci
SN - 12138118
KW - telomere
KW - telomerase
KW - leukemia
KW - lymphoma
KW - hematooncology
KW - aging
UR - https://biomed.papers.upol.cz/pdfs/bio/2019/01/01.pdf
L2 - https://biomed.papers.upol.cz/pdfs/bio/2019/01/01.pdf
N2 - Telomeres are repetitive DNA sequences protecting physical ends of linear chromosomes against degradation and endto- end chromosomal fusion. Telomeres shorten with each cell division, which regulates the cellular lifespan in somatic cells and limits their renewal capacity. Cancer cells are often able to overcome this physiological barrier and become immortal with unlimited replicative capacity. In this review, we present current knowledge on the role of telomeres in human aging with a focus on their behavior in hematological malignancies of adults. Associations of telomere length to age-related diseases and to the prevention of telomere shortening are also discussed.
ER -
OLBERTOVÁ, Helena, Karla PLEVOVÁ, Kamila STRÁNSKÁ a Šárka POSPÍŠILOVÁ. Telomere dynamics in adult hematological malignancies. \textit{Biomedical Papers}. Univerzita Palackého v Olomouci, roč.~163, č.~1, s.~1-7. ISSN~1213-8118. doi:10.5507/bp.2018.084. 2019.
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