Detailed Information on Publication Record
2019
Telomere dynamics in adult hematological malignancies
OLBERTOVÁ, Helena, Karla PLEVOVÁ, Kamila STRÁNSKÁ and Šárka POSPÍŠILOVÁBasic information
Original name
Telomere dynamics in adult hematological malignancies
Authors
OLBERTOVÁ, Helena (203 Czech Republic, belonging to the institution), Karla PLEVOVÁ (203 Czech Republic, belonging to the institution), Kamila STRÁNSKÁ (203 Czech Republic, belonging to the institution) and Šárka POSPÍŠILOVÁ (203 Czech Republic, guarantor, belonging to the institution)
Edition
Biomedical Papers, Univerzita Palackého v Olomouci, 2019, 1213-8118
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
10606 Microbiology
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 1.000
RIV identification code
RIV/00216224:14110/19:00108581
Organization unit
Faculty of Medicine
UT WoS
000458362500001
Keywords in English
telomere; telomerase; leukemia; lymphoma; hematooncology; aging
Tags
International impact, Reviewed
Změněno: 4/3/2020 17:59, Mgr. Pavla Foltynová, Ph.D.
Abstract
V originále
Telomeres are repetitive DNA sequences protecting physical ends of linear chromosomes against degradation and endto- end chromosomal fusion. Telomeres shorten with each cell division, which regulates the cellular lifespan in somatic cells and limits their renewal capacity. Cancer cells are often able to overcome this physiological barrier and become immortal with unlimited replicative capacity. In this review, we present current knowledge on the role of telomeres in human aging with a focus on their behavior in hematological malignancies of adults. Associations of telomere length to age-related diseases and to the prevention of telomere shortening are also discussed.
Links
| NV15-31834A, research and development project |
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