OLBERTOVÁ, Helena, Karla PLEVOVÁ, Kamila STRÁNSKÁ and Šárka POSPÍŠILOVÁ. Telomere dynamics in adult hematological malignancies. Biomedical Papers. Univerzita Palackého v Olomouci, 2019, vol. 163, No 1, p. 1-7. ISSN 1213-8118. Available from: https://dx.doi.org/10.5507/bp.2018.084. |
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@article{1614340, author = {Olbertová, Helena and Plevová, Karla and Stránská, Kamila and Pospíšilová, Šárka}, article_number = {1}, doi = {http://dx.doi.org/10.5507/bp.2018.084}, keywords = {telomere; telomerase; leukemia; lymphoma; hematooncology; aging}, language = {eng}, issn = {1213-8118}, journal = {Biomedical Papers}, title = {Telomere dynamics in adult hematological malignancies}, url = {https://biomed.papers.upol.cz/pdfs/bio/2019/01/01.pdf}, volume = {163}, year = {2019} }
TY - JOUR ID - 1614340 AU - Olbertová, Helena - Plevová, Karla - Stránská, Kamila - Pospíšilová, Šárka PY - 2019 TI - Telomere dynamics in adult hematological malignancies JF - Biomedical Papers VL - 163 IS - 1 SP - 1-7 EP - 1-7 PB - Univerzita Palackého v Olomouci SN - 12138118 KW - telomere KW - telomerase KW - leukemia KW - lymphoma KW - hematooncology KW - aging UR - https://biomed.papers.upol.cz/pdfs/bio/2019/01/01.pdf L2 - https://biomed.papers.upol.cz/pdfs/bio/2019/01/01.pdf N2 - Telomeres are repetitive DNA sequences protecting physical ends of linear chromosomes against degradation and endto- end chromosomal fusion. Telomeres shorten with each cell division, which regulates the cellular lifespan in somatic cells and limits their renewal capacity. Cancer cells are often able to overcome this physiological barrier and become immortal with unlimited replicative capacity. In this review, we present current knowledge on the role of telomeres in human aging with a focus on their behavior in hematological malignancies of adults. Associations of telomere length to age-related diseases and to the prevention of telomere shortening are also discussed. ER -
OLBERTOVÁ, Helena, Karla PLEVOVÁ, Kamila STRÁNSKÁ and Šárka POSPÍŠILOVÁ. Telomere dynamics in adult hematological malignancies. \textit{Biomedical Papers}. Univerzita Palackého v Olomouci, 2019, vol.~163, No~1, p.~1-7. ISSN~1213-8118. Available from: https://dx.doi.org/10.5507/bp.2018.084.
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