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@article{1614517, author = {Boudný, Miroslav and Trbušek, Martin}, article_location = {Praha}, article_number = {1}, doi = {http://dx.doi.org/10.14735/amko202032}, keywords = {STAT3; STAT; chronic lymphocytic leukaemia; therapy; microenvironment; ibrutinib; con-stitutive activation; leukaemia}, language = {eng}, issn = {0862-495X}, journal = {Klinická onkologie}, title = {The Important Role of STAT3 in Chronic Lymphocytic Leukaemia Biology}, url = {https://www.prolekare.cz/en/journals/clinical-oncology/2020-1-5/the-important-role-of-stat3-in-chronic-lymphocytic-leukaemia-biology-121259}, volume = {33}, year = {2020} }
TY - JOUR ID - 1614517 AU - Boudný, Miroslav - Trbušek, Martin PY - 2020 TI - The Important Role of STAT3 in Chronic Lymphocytic Leukaemia Biology JF - Klinická onkologie VL - 33 IS - 1 SP - 32-38 EP - 32-38 PB - Ambit Media a.s. SN - 0862495X KW - STAT3 KW - STAT KW - chronic lymphocytic leukaemia KW - therapy KW - microenvironment KW - ibrutinib KW - con-stitutive activation KW - leukaemia UR - https://www.prolekare.cz/en/journals/clinical-oncology/2020-1-5/the-important-role-of-stat3-in-chronic-lymphocytic-leukaemia-biology-121259 L2 - https://www.prolekare.cz/en/journals/clinical-oncology/2020-1-5/the-important-role-of-stat3-in-chronic-lymphocytic-leukaemia-biology-121259 N2 - Background: Signal transducer and activator of transcription (STAT) proteins are cytoplasmic tran-scription factors that transmit the signal of cytokines, hormones and growth factors. STAT pro-teins control fundamental cellular processes including survival, proliferation and differentiation.Inappropriate activation of STATs might contribute to cellular transformation and leukaemogene-sis. About 70% of all solid and haematological tumours exhibit aberrant STAT3 expression and/ or activation, highlighting its essential role in tumourigenesis. Aberrant STAT3 activation has been found in several solid tumours and haematologic malignancies. Importantly, constitutive activa-tion of STAT proteins has been found in several leukaemias including acute myeloid leukaemia, acute promyelocytic leukaemia, acute lymphoblastic leukaemia, chronic myeloid leukaemia and chronic lymphocytic leukaemia (CLL). Constitutively activated STAT3 plays an important role in CLL bio logy. CLL cells harbour constitutive phosphorylation on S727 and acetylation on K685 and transient phosphorylation on Y705 residues. Moreover, STAT3 messenger RNA expression is signi-ficantly higher in CLL cells compared to healthy B-lymphocytes. Interestingly, STAT3 inhibition was disclosed as an important by-product of ibrutinib treatment in CLL patients. Purpose: The purpose of this review is to describe the consequences of STAT3 dysregulation in CLL cells. Here, we discuss aberrantly modified processes by STAT3 activation in CLL cells such as proliferation, apoptosis, B cell receptor signalling, cytokine secretion, immune checkpoint regulation, microRNA regulation, free fatty acid metabolism and electron transport chain in the mitochondria. ER -
BOUDNÝ, Miroslav and Martin TRBUŠEK. The Important Role of STAT3 in Chronic Lymphocytic Leukaemia Biology. \textit{Klinická onkologie}. Praha: Ambit Media a.s., 2020, vol.~33, No~1, p.~32-38. ISSN~0862-495X. Available from: https://dx.doi.org/10.14735/amko202032.
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