Detailed Information on Publication Record
2020
Evolutionary concept of inflammatory response and stroke
ĎURIŠ, Kamil and Michal JURAJDABasic information
Original name
Evolutionary concept of inflammatory response and stroke
Authors
ĎURIŠ, Kamil (203 Czech Republic, belonging to the institution) and Michal JURAJDA (203 Czech Republic, guarantor, belonging to the institution)
Edition
Journal of Neuroscience Research, HOBOKEN, WILEY, 2020, 0360-4012
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30103 Neurosciences
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 4.164
RIV identification code
RIV/00216224:14110/20:00115271
Organization unit
Faculty of Medicine
UT WoS
000495891200009
Keywords in English
evolution; inflammation; stroke
Tags
International impact, Reviewed
Změněno: 11/1/2021 14:11, Mgr. Tereza Miškechová
Abstract
V originále
The immune system plays an important role under both physiological and pathological conditions. Immune surveillance as well as defense and healing processes are crucial for the organism, but the immune system has a natural tendency to act aggressively when excessively stimulated. We may assume that the immune system is not designed to deal with severe conditions, such as polytrauma or severe stroke, because these are not compatible with life in the wilderness and evolution has no chance to act in such cases. These conditions are associated with exaggerated/deregulated inflammatory response, which may cause more damage than initial pathology. In this article, we would like to sketch a basic concept of the immune system-brain interactions from the evolutionary point of view and to discuss some implications related to stroke.
Links
| MUNI/11/InGA04/2013, interní kód MU |
|