Non-coding RNAs and Cardiac Arrhythmias

J 2020

Non-coding RNAs and Cardiac Arrhythmias

ŠUSTR, Filip, Zdeněk STÁREK, Miroslav SOUČEK and Jan NOVÁK

Basic information

Original name

Non-coding RNAs and Cardiac Arrhythmias

Authors

ŠUSTR, Filip (203 Czech Republic, belonging to the institution), Zdeněk STÁREK (203 Czech Republic, belonging to the institution), Miroslav SOUČEK (203 Czech Republic, belonging to the institution) and Jan NOVÁK (203 Czech Republic, guarantor, belonging to the institution)

Edition

Advances in Experimental Medicine and Biology, Singapore, Springer, 2020, 0065-2598

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

Singapore

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.622

RIV identification code

RIV/00216224:14110/20:00115272

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1007/978-981-15-1671-9_17

UT WoS

000539026500017

Keywords in English

non-coding RNA; microRNA; arrhythmias; channels

Abstract

V originále

Cardiac arrhythmias represent wide and heterogenic group of disturbances in the cardiac rhythm. Pathophysiology of individual arrhythmias is highly complex and dysfunction in ion channels/currents involved in generation or spreading of action potential is usually documented. Non-coding RNAs (ncRNAs) represent highly variable group of molecules regulating the heart expression program, including regulation of the expression of individual ion channels and intercellular connection proteins, e.g. connexins. Within this chapter, we will describe basic electrophysiological properties of the myocardium. We will focus on action potential generation and spreading in pacemaker and non-pacemaker cells, including description of individual ion channels (natrium, potassium and calcium) and their ncRNA-mediated regulation. Most of the studies have so far focused on microRNAs, thus, their regulatory function will be described into greater detail. Clinical consequences of altered ncRNA regulatory function will also be described together with potential future directions of the research in the field.

Links

LQ1601, research and development project

Name: CEITEC 2020 (Acronym: CEITEC2020)

Investor: Ministry of Education, Youth and Sports of the CR

MUNI/A/1475/2018, interní kód MU

Name: Diferenciální diagnostika a odhad prognózy interních nemocí 3 (Acronym: DIDIPRON 3)

Investor: Masaryk University, Category A

Citovat

ŠUSTR, Filip, Zdeněk STÁREK, Miroslav SOUČEK and Jan NOVÁK. Non-coding RNAs and Cardiac Arrhythmias. Advances in Experimental Medicine and Biology. Singapore: Springer, 2020, vol. 1229, No 2020, p. 287-300. ISSN 0065-2598. Available from: https://dx.doi.org/10.1007/978-981-15-1671-9_17.

@article{1614636,
   author = {Šustr, Filip and Stárek, Zdeněk and Souček, Miroslav and Novák, Jan},
   article_location = {Singapore},
   article_number = {2020},
   doi = {http://dx.doi.org/10.1007/978-981-15-1671-9_17},
   keywords = {non-coding RNA; microRNA; arrhythmias; channels},
   language = {eng},
   issn = {0065-2598},
   journal = {Advances in Experimental Medicine and Biology},
   title = {Non-coding RNAs and Cardiac Arrhythmias},
   url = {https://link.springer.com/chapter/10.1007%2F978-981-15-1671-9_17},
   volume = {1229},
   year = {2020}
}

TY  - JOUR
ID  - 1614636
AU  - Šustr, Filip - Stárek, Zdeněk - Souček, Miroslav - Novák, Jan
PY  - 2020
TI  - Non-coding RNAs and Cardiac Arrhythmias
JF  - Advances in Experimental Medicine and Biology
VL  - 1229
IS  - 2020
SP  - 287-300
EP  - 287-300
PB  - Springer
SN  - 00652598
KW  - non-coding RNA
KW  - microRNA
KW  - arrhythmias
KW  - channels
UR  - https://link.springer.com/chapter/10.1007%2F978-981-15-1671-9_17
L2  - https://link.springer.com/chapter/10.1007%2F978-981-15-1671-9_17
N2  - Cardiac arrhythmias represent wide and heterogenic group of disturbances in the cardiac rhythm. Pathophysiology of individual arrhythmias is highly complex and dysfunction in ion channels/currents involved in generation or spreading of action potential is usually documented. Non-coding RNAs (ncRNAs) represent highly variable group of molecules regulating the heart expression program, including regulation of the expression of individual ion channels and intercellular connection proteins, e.g. connexins. Within this chapter, we will describe basic electrophysiological properties of the myocardium. We will focus on action potential generation and spreading in pacemaker and non-pacemaker cells, including description of individual ion channels (natrium, potassium and calcium) and their ncRNA-mediated regulation. Most of the studies have so far focused on microRNAs, thus, their regulatory function will be described into greater detail. Clinical consequences of altered ncRNA regulatory function will also be described together with potential future directions of the research in the field.
ER  -

ŠUSTR, Filip, Zdeněk STÁREK, Miroslav SOUČEK and Jan NOVÁK. Non-coding RNAs and Cardiac Arrhythmias. \textit{Advances in Experimental Medicine and Biology}. Singapore: Springer, 2020, vol.~1229, No~2020, p.~287-300. ISSN~0065-2598. Available from: https://dx.doi.org/10.1007/978-981-15-1671-9\_{}17.

Detailed Information on Publication Record