Detailed Information on Publication Record

ŠUSTR, Filip, Zdeněk STÁREK, Miroslav SOUČEK and Jan NOVÁK. Non-coding RNAs and Cardiac Arrhythmias. Advances in Experimental Medicine and Biology. Singapore: Springer, 2020, vol. 1229, No 2020, p. 287-300. ISSN 0065-2598. Available from: https://dx.doi.org/10.1007/978-981-15-1671-9_17.

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Basic information
Original name	Non-coding RNAs and Cardiac Arrhythmias
Authors	ŠUSTR, Filip (203 Czech Republic, belonging to the institution), Zdeněk STÁREK (203 Czech Republic, belonging to the institution), Miroslav SOUČEK (203 Czech Republic, belonging to the institution) and Jan NOVÁK (203 Czech Republic, guarantor, belonging to the institution).
Edition	Advances in Experimental Medicine and Biology, Singapore, Springer, 2020, 0065-2598.

Other information
Original language	English
Type of outcome	Article in a journal
Field of Study	30201 Cardiac and Cardiovascular systems
Country of publisher	Singapore
Confidentiality degree	is not subject to a state or trade secret
WWW	URL
Impact factor	Impact factor: 2.622
RIV identification code	RIV/00216224:14110/20:00115272
Organization unit	Faculty of Medicine
Doi	http://dx.doi.org/10.1007/978-981-15-1671-9_17
UT WoS	000539026500017
Keywords in English	non-coding RNA; microRNA; arrhythmias; channels
Tags	14110115, 14110116, podil, rivok
Tags	International impact, Reviewed
Changed by	Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 14/9/2021 10:14.

Abstract
Cardiac arrhythmias represent wide and heterogenic group of disturbances in the cardiac rhythm. Pathophysiology of individual arrhythmias is highly complex and dysfunction in ion channels/currents involved in generation or spreading of action potential is usually documented. Non-coding RNAs (ncRNAs) represent highly variable group of molecules regulating the heart expression program, including regulation of the expression of individual ion channels and intercellular connection proteins, e.g. connexins. Within this chapter, we will describe basic electrophysiological properties of the myocardium. We will focus on action potential generation and spreading in pacemaker and non-pacemaker cells, including description of individual ion channels (natrium, potassium and calcium) and their ncRNA-mediated regulation. Most of the studies have so far focused on microRNAs, thus, their regulatory function will be described into greater detail. Clinical consequences of altered ncRNA regulatory function will also be described together with potential future directions of the research in the field.

Abstract

Cardiac arrhythmias represent wide and heterogenic group of disturbances in the cardiac rhythm. Pathophysiology of individual arrhythmias is highly complex and dysfunction in ion channels/currents involved in generation or spreading of action potential is usually documented. Non-coding RNAs (ncRNAs) represent highly variable group of molecules regulating the heart expression program, including regulation of the expression of individual ion channels and intercellular connection proteins, e.g. connexins. Within this chapter, we will describe basic electrophysiological properties of the myocardium. We will focus on action potential generation and spreading in pacemaker and non-pacemaker cells, including description of individual ion channels (natrium, potassium and calcium) and their ncRNA-mediated regulation. Most of the studies have so far focused on microRNAs, thus, their regulatory function will be described into greater detail. Clinical consequences of altered ncRNA regulatory function will also be described together with potential future directions of the research in the field.

Links
LQ1601, research and development project	Name: CEITEC 2020 (Acronym: CEITEC2020)
LQ1601, research and development project	Investor: Ministry of Education, Youth and Sports of the CR
MUNI/A/1475/2018, interní kód MU	Name: Diferenciální diagnostika a odhad prognózy interních nemocí 3 (Acronym: DIDIPRON 3)
MUNI/A/1475/2018, interní kód MU	Investor: Masaryk University, Category A