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@article{1615197,
author = {Bubova, Kristyna and Forejtova, Sarka and Zegzulkova, Katerina and Gregova, Monika and Husakova, Marketa and Filkova, Maria and Horinkova, Jana and Gatterova, Jindriska and Tomcik, Michal and Szczuková, Lenka and Pavelka, Karel and Senolt, Ladislav},
article_location = {London},
article_number = {4},
doi = {http://dx.doi.org/10.1136/bmjopen-2018-024713},
keywords = {ANKYLOSING-SPONDYLITIS PATIENTS; DISEASE-ACTIVITY; PART},
language = {eng},
issn = {2044-6055},
journal = {BMJ Open},
title = {Cross-sectional study of patients with axial spondyloarthritis fulfilling imaging arm of ASAS classification criteria: baseline clinical characteristics and subset differences in a single-centre cohort},
url = {http://dx.doi.org/10.1136/bmjopen-2018-024713},
volume = {9},
year = {2019}
}
TY - JOUR
ID - 1615197
AU - Bubova, Kristyna - Forejtova, Sarka - Zegzulkova, Katerina - Gregova, Monika - Husakova, Marketa - Filkova, Maria - Horinkova, Jana - Gatterova, Jindriska - Tomcik, Michal - Szczuková, Lenka - Pavelka, Karel - Senolt, Ladislav
PY - 2019
TI - Cross-sectional study of patients with axial spondyloarthritis fulfilling imaging arm of ASAS classification criteria: baseline clinical characteristics and subset differences in a single-centre cohort
JF - BMJ Open
VL - 9
IS - 4
SP - 1-6
EP - 1-6
PB - BMJ Publishing Group
SN - 20446055
KW - ANKYLOSING-SPONDYLITIS PATIENTS
KW - DISEASE-ACTIVITY
KW - PART
UR - http://dx.doi.org/10.1136/bmjopen-2018-024713
L2 - http://dx.doi.org/10.1136/bmjopen-2018-024713
N2 - Objective This study compared demographic, clinical and laboratory characteristics between patients with radiographic and non-radiographic axial spondyloarthritis (axSpA). Methods In this single-centre cross-sectional study, a total of 246 patients with axSpA fulfilling the imaging arm of Assessment of SpondyloArthritis International Society classification criteria were recruited. A total of 140 patients were diagnosed as non-radiographic axial spondyloarthritis (nr-axSpA), and 106 patients had ankylosing spondylitis (AS). Sociodemographic characteristics, disease manifestations, clinical and laboratory disease activity and their differences between subsets were analysed. P values below 0.05 with CI 95% were considered statistically significant. Results More nr-axSpA patients were women (61.4%) compared with 24.7% of AS patients. First symptoms developed earlier in AS patients compared with nr-axSpA (23.0 (IQR 17.5-30.0) vs 27.8 (IQR 21.0-33.7) years, p=0.001). Disease manifestations did not differ, but patients with nr-axSpA experienced peripheral arthritis more frequently (35.7% vs 17.0%, p=0.001) with less hip involvement (8.6% vs 18.9%, p=0.022) compared with patients with AS. Patients with AS exhibited worse spinal mobility and physical function compared with nr-axSpA. AS Disease Activity Scores and CRP levels were significantly higher in patients with AS compared with nr-axSpA (2.4 (IQR 1.7-2.8) vs 2.0 (IQR 1.1-2.3), p=0.022 and 7.1 (IQR 2.6-14.9) vs 2.5 (IQR 0.8-8.2) mg/L, p<0.001, respectively). Conclusions Our data demonstrated some known and also novel differences between the two imaging arm fulfilling axSpA subgroups. Non-radiographic patients were mostly women who had experienced shorter disease duration, milder disease activity and better functional status with less hip involvement but more peripheral arthritis compared with patients with AS.
ER -
BUBOVA, Kristyna, Sarka FOREJTOVA, Katerina ZEGZULKOVA, Monika GREGOVA, Marketa HUSAKOVA, Maria FILKOVA, Jana HORINKOVA, Jindriska GATTEROVA, Michal TOMCIK, Lenka SZCZUKOVÁ, Karel PAVELKA and Ladislav SENOLT. Cross-sectional study of patients with axial spondyloarthritis fulfilling imaging arm of ASAS classification criteria: baseline clinical characteristics and subset differences in a single-centre cohort. \textit{BMJ Open}. London: BMJ Publishing Group, 2019, vol.~9, No~4, p.~1-6. ISSN~2044-6055. Available from: https://dx.doi.org/10.1136/bmjopen-2018-024713.
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