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@proceedings{1615539,
author = {Štark, Tibor and Giurdanella, Giovanni and Pekařík, Vladimír and Kuchar, Martin and Babinská, Zuzana and Rudá, Jana and Salomone, Salvatore and Mechoulam, Raphael and Drago, Filippo and Šulcová, Alexandra and Micale, Vincenzo},
booktitle = {31st Congress of the European-College-of-Neuropsychopharmacology (ECNP)},
doi = {http://dx.doi.org/10.1016/j.euroneuro.2018.11.407},
keywords = {Peripubertal treatment; annabidiol reverses behavioral alterations},
language = {eng},
title = {Peripubertal treatment with cannabidiol reverses behavioral alterations in Delta 9-THC animal model of schizophrenia},
url = {https://www.ecnp.eu/presentationpdfs/73/P.297.pdf},
year = {2019}
}
TY - CONF
ID - 1615539
AU - Štark, Tibor - Giurdanella, Giovanni - Pekařík, Vladimír - Kuchar, Martin - Babinská, Zuzana - Rudá, Jana - Salomone, Salvatore - Mechoulam, Raphael - Drago, Filippo - Šulcová, Alexandra - Micale, Vincenzo
PY - 2019
TI - Peripubertal treatment with cannabidiol reverses behavioral alterations in Delta 9-THC animal model of schizophrenia
KW - Peripubertal treatment
KW - annabidiol reverses behavioral alterations
UR - https://www.ecnp.eu/presentationpdfs/73/P.297.pdf
L2 - https://www.ecnp.eu/presentationpdfs/73/P.297.pdf
N2 - Several studies suggest that disturbances in the neurodevelopment could lead to schizophrenia (SCZ), a psychiatric disorder with severe symptoms in cognitive and social domains. While a variety of studies emphasize the role of the endocannabinoid system (ECS) in the neurodevelopmental dysregulation during perinatal and adolescent periods, mostly arising fromwell-known long-lasting negative effects of delta-9-tetrahydrocannabinol very little attention is dedicated to the positive potential of the ECS modulation in these sensitive periods as a preventive intervention. Given that preventive antipsychotic treatment seems to reduce the risk of transition to psychosis in vulnerable individuals, we hypothesized early modulation of ECS could be a potential novel therapeutic strategy.
ER -
ŠTARK, Tibor, Giovanni GIURDANELLA, Vladimír PEKAŘÍK, Martin KUCHAR, Zuzana BABINSKÁ, Jana RUDÁ, Salvatore SALOMONE, Raphael MECHOULAM, Filippo DRAGO, Alexandra ŠULCOVÁ a Vincenzo MICALE. Peripubertal treatment with cannabidiol reverses behavioral alterations in Delta 9-THC animal model of schizophrenia. In \textit{31st Congress of the European-College-of-Neuropsychopharmacology (ECNP)}. 2019. ISSN~0924-977X. Dostupné z: https://dx.doi.org/10.1016/j.euroneuro.2018.11.407.
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