ŠTARK, Tibor, Giovanni GIURDANELLA, Vladimír PEKAŘÍK, Martin KUCHAR, Zuzana BABINSKÁ, Jana RUDÁ, Salvatore SALOMONE, Raphael MECHOULAM, Filippo DRAGO, Alexandra ŠULCOVÁ and Vincenzo MICALE. Peripubertal treatment with cannabidiol reverses behavioral alterations in Delta 9-THC animal model of schizophrenia. In 31st Congress of the European-College-of-Neuropsychopharmacology (ECNP). 2019. ISSN 0924-977X. Available from: https://dx.doi.org/10.1016/j.euroneuro.2018.11.407.
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Basic information
Original name Peripubertal treatment with cannabidiol reverses behavioral alterations in Delta 9-THC animal model of schizophrenia
Authors ŠTARK, Tibor (703 Slovakia, guarantor, belonging to the institution), Giovanni GIURDANELLA (380 Italy), Vladimír PEKAŘÍK (203 Czech Republic, belonging to the institution), Martin KUCHAR (203 Czech Republic), Zuzana BABINSKÁ (703 Slovakia, belonging to the institution), Jana RUDÁ (203 Czech Republic, belonging to the institution), Salvatore SALOMONE (380 Italy), Raphael MECHOULAM, Filippo DRAGO (380 Italy), Alexandra ŠULCOVÁ (203 Czech Republic, belonging to the institution) and Vincenzo MICALE (380 Italy).
Edition 31st Congress of the European-College-of-Neuropsychopharmacology (ECNP), 2019.
Other information
Original language English
Type of outcome Conference abstract
Field of Study 30301 Social biomedical sciences
Country of publisher Netherlands
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 3.853
RIV identification code RIV/00216224:14110/19:00112856
Organization unit Faculty of Medicine
ISSN 0924-977X
Doi http://dx.doi.org/10.1016/j.euroneuro.2018.11.407
UT WoS 000458400500350
Keywords in English Peripubertal treatment; annabidiol reverses behavioral alterations
Tags rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 14/4/2020 13:22.
Abstract
Several studies suggest that disturbances in the neurodevelopment could lead to schizophrenia (SCZ), a psychiatric disorder with severe symptoms in cognitive and social domains. While a variety of studies emphasize the role of the endocannabinoid system (ECS) in the neurodevelopmental dysregulation during perinatal and adolescent periods, mostly arising fromwell-known long-lasting negative effects of delta-9-tetrahydrocannabinol very little attention is dedicated to the positive potential of the ECS modulation in these sensitive periods as a preventive intervention. Given that preventive antipsychotic treatment seems to reduce the risk of transition to psychosis in vulnerable individuals, we hypothesized early modulation of ECS could be a potential novel therapeutic strategy.
Links
MUNI/A/1132/2017, interní kód MUName: Behaviorální psychofarmakologie a farmakokinetika v preklinickém výzkumu léčiv
Investor: Masaryk University, Category A
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