Risk Factors in Ischemic Stroke Subtypes: a Community-Based
Study in Brno, Czech Republic

J 2020

Risk Factors in Ischemic Stroke Subtypes: a Community-Based Study in Brno, Czech Republic

JACKOVÁ, Jana, Petra ŠEDOVÁ, Robert D., Jr. BROWN, Miroslav ZVOLSKÝ, Silvie BĚLAŠKOVÁ et. al.

Basic information

Original name

Risk Factors in Ischemic Stroke Subtypes: a Community-Based Study in Brno, Czech Republic

Authors

JACKOVÁ, Jana (703 Slovakia, belonging to the institution), Petra ŠEDOVÁ (203 Czech Republic, belonging to the institution), Robert D., Jr. BROWN (840 United States of America), Miroslav ZVOLSKÝ (203 Czech Republic), Silvie BĚLAŠKOVÁ (203 Czech Republic), Michaela VOLNÁ (203 Czech Republic), Jana BALUCHOVÁ (203 Czech Republic), Josef BEDNAŘÍK (203 Czech Republic, belonging to the institution) and Robert MIKULÍK (203 Czech Republic, guarantor, belonging to the institution)

Edition

Journal of Stroke & Cerebrovascular Diseases, Amsterdam, Elsevier, 2020, 1052-3057

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.136

RIV identification code

RIV/00216224:14110/20:00115307

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.104503

UT WoS

000505793800045

Keywords in English

Stroke; ischemic stroke subtypes; TOAST classification; risk factors; Czech Republic

Abstract

V originále

Background: It is not known if risk factors differ between ischemic stroke (IS) subtypes in Central and Eastern Europe. Aims: We performed a community-based analysis of risk factors in patients admitted with IS over a 1 year period in Brno, the second largest city in the Czech Republic (CR). Methods: Based on the National Register of Hospitalized Patients, all patients with IS admitted in Brno in 2011 were identified. Comprehensive discharge summaries from hospital admissions were collected and reviewed. IS subtype and relevant risk factors were ascertained for all patients. The age- and sex-adjusted association of risk factors with IS subtypes was determined. Results: Overall, 682 patients with IS were admitted in 2011 to Brno hospitals. The distribution of IS subtypes was: 35% cardioembolism, 28% large-artery atherosclerosis, 23% small-artery occlusion, 7% stroke of undetermined etiology, 7% stroke of other determined etiology. Several of the risk factors showed high prevalence in the overall sample - e.g. hypertension (84%) and hyperlipidemia (61%). Cardioembolism as compared to other subtypes was positively associated with a history of myocardial infarction, cardiac failure, and atrial fibrillation. Small-artery occlusion was positively associated with history of dementia. No significant association was found between IS subtypes and history of IS, hypertension, diabetes, obesity, alcohol abuse or smoking. Conclusions: We found high frequency of stroke risk factors in all IS subtypes. These findings have implications for stroke prevention strategies in the CR and across Central Europe.

Links

LM2015090, research and development project

Name: Český národní uzel Evropské sítě infrastruktur klinického výzkumu (Acronym: CZECRIN)

Investor: Ministry of Education, Youth and Sports of the CR

Citovat

JACKOVÁ, Jana, Petra ŠEDOVÁ, Robert D., Jr. BROWN, Miroslav ZVOLSKÝ, Silvie BĚLAŠKOVÁ, Michaela VOLNÁ, Jana BALUCHOVÁ, Josef BEDNAŘÍK and Robert MIKULÍK. Risk Factors in Ischemic Stroke Subtypes: a Community-Based Study in Brno, Czech Republic. Journal of Stroke & Cerebrovascular Diseases. Amsterdam: Elsevier, 2020, vol. 29, No 2, p. 1-8. ISSN 1052-3057. Available from: https://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.104503.

@article{1619197,
   author = {Jacková, Jana and Šedová, Petra and Brown, Robert D., Jr. and Zvolský, Miroslav and Bělašková, Silvie and Volná, Michaela and Baluchová, Jana and Bednařík, Josef and Mikulík, Robert},
   article_location = {Amsterdam},
   article_number = {2},
   doi = {http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.104503},
   keywords = {Stroke; ischemic stroke subtypes; TOAST classification; risk factors; Czech Republic},
   language = {eng},
   issn = {1052-3057},
   journal = {Journal of Stroke & Cerebrovascular Diseases},
   title = {Risk Factors in Ischemic Stroke Subtypes: a Community-Based Study in Brno, Czech Republic},
   url = {http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.104503},
   volume = {29},
   year = {2020}
}

TY  - JOUR
ID  - 1619197
AU  - Jacková, Jana - Šedová, Petra - Brown, Robert D., Jr. - Zvolský, Miroslav - Bělašková, Silvie - Volná, Michaela - Baluchová, Jana - Bednařík, Josef - Mikulík, Robert
PY  - 2020
TI  - Risk Factors in Ischemic Stroke Subtypes: a Community-Based Study in Brno, Czech Republic
JF  - Journal of Stroke & Cerebrovascular Diseases
VL  - 29
IS  - 2
SP  - 1-8
EP  - 1-8
PB  - Elsevier
SN  - 10523057
KW  - Stroke
KW  - ischemic stroke subtypes
KW  - TOAST classification
KW  - risk factors
KW  - Czech Republic
UR  - http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.104503
L2  - http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.104503
N2  - Background: It is not known if risk factors differ between ischemic stroke (IS) subtypes in Central and Eastern Europe. Aims: We performed a community-based analysis of risk factors in patients admitted with IS over a 1 year period in Brno, the second largest city in the Czech Republic (CR). Methods: Based on the National Register of Hospitalized Patients, all patients with IS admitted in Brno in 2011 were identified. Comprehensive discharge summaries from hospital admissions were collected and reviewed. IS subtype and relevant risk factors were ascertained for all patients. The age- and sex-adjusted association of risk factors with IS subtypes was determined. Results: Overall, 682 patients with IS were admitted in 2011 to Brno hospitals. The distribution of IS subtypes was: 35% cardioembolism, 28% large-artery atherosclerosis, 23% small-artery occlusion, 7% stroke of undetermined etiology, 7% stroke of other determined etiology. Several of the risk factors showed high prevalence in the overall sample - e.g. hypertension (84%) and hyperlipidemia (61%). Cardioembolism as compared to other subtypes was positively associated with a history of myocardial infarction, cardiac failure, and atrial fibrillation. Small-artery occlusion was positively associated with history of dementia. No significant association was found between IS subtypes and history of IS, hypertension, diabetes, obesity, alcohol abuse or smoking. Conclusions: We found high frequency of stroke risk factors in all IS subtypes. These findings have implications for stroke prevention strategies in the CR and across Central Europe.
ER  -

JACKOVÁ, Jana, Petra ŠEDOVÁ, Robert D., Jr. BROWN, Miroslav ZVOLSKÝ, Silvie BĚLAŠKOVÁ, Michaela VOLNÁ, Jana BALUCHOVÁ, Josef BEDNAŘÍK and Robert MIKULÍK. Risk Factors in Ischemic Stroke Subtypes: a Community-Based Study in Brno, Czech Republic. \textit{Journal of Stroke \&{} Cerebrovascular Diseases}. Amsterdam: Elsevier, 2020, vol.~29, No~2, p.~1-8. ISSN~1052-3057. Available from: https://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.104503.

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