J 2020

The role of cannabinoids in the treatment of cancer

VEČEŘA, Lubomír, Tomáš GABRHELÍK, Petr PRÁŠIL and Petr ŠTOURAČ

Basic information

Original name

The role of cannabinoids in the treatment of cancer

Authors

VEČEŘA, Lubomír (203 Czech Republic, belonging to the institution), Tomáš GABRHELÍK (203 Czech Republic, guarantor), Petr PRÁŠIL (203 Czech Republic) and Petr ŠTOURAČ (203 Czech Republic, belonging to the institution)

Edition

Bratislava Medical Journal - Bratislavské lekárske listy, BRATISLAVA, Univerzita Komenského, 2020, 0006-9248

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30223 Anaesthesiology

Country of publisher

Slovakia

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 1.278

RIV identification code

RIV/00216224:14110/20:00115321

Organization unit

Faculty of Medicine

DOI

UT WoS

000507926100012

Keywords in English

cannabinoids; cannabinoid receptor; cancer; oncological diseases; cancer treatment

Tags

Tags

International impact, Reviewed
Změněno: 13/2/2020 14:00, Mgr. Tereza Miškechová

Abstract

V originále

AIM: The aim of this review article is to summarize current knowledge about the role of cannabinoids and cannabinoid receptors in tumor disease modulation and to evaluate comprehensively the use of cannabinoids in cancer patients. METHOD: According to the PRISMA protocol, we have included data from a total of 105 articles. RESULTS: Cannabinoids affect cancer progression by three mechanisms. The most important mechanism is the stimulation of autophagy and affecting the signaling pathways leading to apoptosis. The most important mechanism of this process is the accumulation of ceramide. Cannabinoids also stimulate apoptosis by mechanisms independent of autophagy. Other mechanisms by which cannabinoids affect tumor growth are inhibition of tumor angiogenesis, invasiveness, metastasis, and the modulation of the anti-tumor immune response. CONCLUSION: In addition to the symptomatic therapy of cancer patients, the antitumor effects of cannabinoids (whether in monotherapy or in combination with other cancer therapies) have promising potential in the treatment of cancer patients. More clinical trials are needed to demonstrate the antitumor effect of cannabinoids (Tab. 1, Fig. 1, Ref. 167).