Addition of IMP3 to L1CAM for discrimination between low- and
high-grade endometrial carcinomas: a European Network for
Individualised Treatment of Endometrial Cancer collaboration
study

J 2019

Addition of IMP3 to L1CAM for discrimination between low- and high-grade endometrial carcinomas: a European Network for Individualised Treatment of Endometrial Cancer collaboration study

VISSER, Nicole C. M., Louis J. M. VAN DER PUTTEN, Alex VAN EGERSCHOT, Koen K. VAN DE VIJVER, Maria SANTACANA et. al.

Basic information

Original name

Addition of IMP3 to L1CAM for discrimination between low- and high-grade endometrial carcinomas: a European Network for Individualised Treatment of Endometrial Cancer collaboration study

Authors

VISSER, Nicole C. M. (528 Netherlands, guarantor), Louis J. M. VAN DER PUTTEN (528 Netherlands), Alex VAN EGERSCHOT (528 Netherlands), Koen K. VAN DE VIJVER (56 Belgium), Maria SANTACANA (724 Spain), Peter BRONSERT (276 Germany), Marc HIRSCHFELD (276 Germany), Eva COLAS (724 Spain), Antonio GIL-MORENO (724 Spain), Angel GARCIA (724 Spain), Gemma MANCEBO (724 Spain), Francesc ALAMEDA (724 Spain), Camilla KRAKSTAD (578 Norway), Ingvild L. TANGEN (578 Norway), Jutta HUVILA (246 Finland), Stefanie SCHRAUWEN (56 Belgium), Martin KOSKAS (250 France), Francine WALKER (250 France), Vít WEINBERGER (203 Czech Republic, belonging to the institution), Luboš MINÁŘ (203 Czech Republic, belonging to the institution), Jitka HAUSNEROVÁ (203 Czech Republic, belonging to the institution), Marc P. L. M. SNIJDERS (528 Netherlands), Saskia VAN DEN BERG-VAN ERP (528 Netherlands), Xavier MATIAS-GUIU (724 Spain), Jone TROVIK (578 Norway), Frederic AMANT (56 Belgium), Leon F. A. G. MASSUGER (528 Netherlands), Johan BULTEN (528 Netherlands) and Johanna M. A. PIJNENBORG (528 Netherlands)

Edition

Human pathology, Philadelphia, PA, W.B. Saunders Company, 2019, 0046-8177

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30109 Pathology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.735

RIV identification code

RIV/00216224:14110/19:00112954

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.humpath.2019.04.014

UT WoS

000477688900011

Keywords in English

Endometrial carcinoma; Diagnostic biomarker; Prognostic biomarker; IMP3; L1CAM

Abstract

V originále

Discrimination between low- and high-grade endometrial carcinomas (ECs) is clinically relevant but can be challenging for pathologists, with moderate interobserver agreement. Insulin-like growth factor-II mRNA-binding protein 3 (IMP3) is an oncofoetal protein that is associated with nonendometrioid endometrial carcinomas but has been limited studied in endometrioid carcinomas. The aim of this study is to investigate the diagnostic and prognostic value of IMP3 in the discrimination between low- and high-grade ECs and its added value to L1CAM. IMP3 and L1CAM expression was assessed in tumors from 378 patients treated for EC at 1 of 9 participating European Network for Individualised Treatment of Endometrial Cancer centers. IMP3 was expressed in 24.6% of the tumors. In general, IMP3 was more homogeneously expressed than L1CAM. IMP3 expression was significantly associated with advanced stage, nonendometrioid histology, grade 3 tumors, deep myometrial invasion, lymphovascular space invasion, distant recurrences, overall mortality, and disease-related mortality. Simultaneous absence of IMP3 and Ll CAM expression showed the highest accuracy for identifying low-grade carcinomas (area under the curve 0.766), whereas simultaneous expression of IMP3 and L1CAM was strongly associated with high-grade carcinomas (odds ratio 19.7; 95% confidence interval 9.2-42.2). Even within endometrioid carcinomas, this combination remained superior to IMP3 and L1CAM alone (odds ratio 8.6; 95% confidence interval 3.4-21.9). In conclusion, IMP3 has good diagnostic value and together with L1CAM represents the optimal combination of diagnostic markers for discrimination between low- and high-grade ECs compared to IMP3 and L1CAM alone. Because of the homogenous expression of IMP3, this marker might be valuable in preoperative biopsies when compared to the more patchy L1CAM expression. (C) 2019 Elsevier Inc. All rights reserved.

Citovat

VISSER, Nicole C. M., Louis J. M. VAN DER PUTTEN, Alex VAN EGERSCHOT, Koen K. VAN DE VIJVER, Maria SANTACANA, Peter BRONSERT, Marc HIRSCHFELD, Eva COLAS, Antonio GIL-MORENO, Angel GARCIA, Gemma MANCEBO, Francesc ALAMEDA, Camilla KRAKSTAD, Ingvild L. TANGEN, Jutta HUVILA, Stefanie SCHRAUWEN, Martin KOSKAS, Francine WALKER, Vít WEINBERGER, Luboš MINÁŘ, Jitka HAUSNEROVÁ, Marc P. L. M. SNIJDERS, Saskia VAN DEN BERG-VAN ERP, Xavier MATIAS-GUIU, Jone TROVIK, Frederic AMANT, Leon F. A. G. MASSUGER, Johan BULTEN and Johanna M. A. PIJNENBORG. Addition of IMP3 to L1CAM for discrimination between low- and high-grade endometrial carcinomas: a European Network for Individualised Treatment of Endometrial Cancer collaboration study. Human pathology. Philadelphia, PA: W.B. Saunders Company, 2019, vol. 89, JUL 2019, p. 90-98. ISSN 0046-8177. Available from: https://dx.doi.org/10.1016/j.humpath.2019.04.014.

@article{1622896,
   author = {Visser, Nicole C. M. and van der Putten, Louis J. M. and van Egerschot, Alex and van de Vijver, Koen K. and Santacana, Maria and Bronsert, Peter and Hirschfeld, Marc and Colas, Eva and GilandMoreno, Antonio and Garcia, Angel and Mancebo, Gemma and Alameda, Francesc and Krakstad, Camilla and Tangen, Ingvild L. and Huvila, Jutta and Schrauwen, Stefanie and Koskas, Martin and Walker, Francine and Weinberger, Vít and Minář, Luboš and Hausnerová, Jitka and Snijders, Marc P. L. M. and van den Bergandvan Erp, Saskia and MatiasandGuiu, Xavier and Trovik, Jone and Amant, Frederic and Massuger, Leon F. A. G. and Bulten, Johan and Pijnenborg, Johanna M. A.},
   article_location = {Philadelphia, PA},
   article_number = {JUL 2019},
   doi = {http://dx.doi.org/10.1016/j.humpath.2019.04.014},
   keywords = {Endometrial carcinoma; Diagnostic biomarker; Prognostic biomarker; IMP3; L1CAM},
   language = {eng},
   issn = {0046-8177},
   journal = {Human pathology},
   title = {Addition of IMP3 to L1CAM for discrimination between low- and high-grade endometrial carcinomas: a European Network for Individualised Treatment of Endometrial Cancer collaboration study},
   url = {http://dx.doi.org/10.1016/j.humpath.2019.04.014},
   volume = {89},
   year = {2019}
}

TY  - JOUR
ID  - 1622896
AU  - Visser, Nicole C. M. - van der Putten, Louis J. M. - van Egerschot, Alex - van de Vijver, Koen K. - Santacana, Maria - Bronsert, Peter - Hirschfeld, Marc - Colas, Eva - Gil-Moreno, Antonio - Garcia, Angel - Mancebo, Gemma - Alameda, Francesc - Krakstad, Camilla - Tangen, Ingvild L. - Huvila, Jutta - Schrauwen, Stefanie - Koskas, Martin - Walker, Francine - Weinberger, Vít - Minář, Luboš - Hausnerová, Jitka - Snijders, Marc P. L. M. - van den Berg-van Erp, Saskia - Matias-Guiu, Xavier - Trovik, Jone - Amant, Frederic - Massuger, Leon F. A. G. - Bulten, Johan - Pijnenborg, Johanna M. A.
PY  - 2019
TI  - Addition of IMP3 to L1CAM for discrimination between low- and high-grade endometrial carcinomas: a European Network for Individualised Treatment of Endometrial Cancer collaboration study
JF  - Human pathology
VL  - 89
IS  - JUL 2019
SP  - 90-98
EP  - 90-98
PB  - W.B. Saunders Company
SN  - 00468177
KW  - Endometrial carcinoma
KW  - Diagnostic biomarker
KW  - Prognostic biomarker
KW  - IMP3
KW  - L1CAM
UR  - http://dx.doi.org/10.1016/j.humpath.2019.04.014
L2  - http://dx.doi.org/10.1016/j.humpath.2019.04.014
N2  - Discrimination between low- and high-grade endometrial carcinomas (ECs) is clinically relevant but can be challenging for pathologists, with moderate interobserver agreement. Insulin-like growth factor-II mRNA-binding protein 3 (IMP3) is an oncofoetal protein that is associated with nonendometrioid endometrial carcinomas but has been limited studied in endometrioid carcinomas. The aim of this study is to investigate the diagnostic and prognostic value of IMP3 in the discrimination between low- and high-grade ECs and its added value to L1CAM. IMP3 and L1CAM expression was assessed in tumors from 378 patients treated for EC at 1 of 9 participating European Network for Individualised Treatment of Endometrial Cancer centers. IMP3 was expressed in 24.6% of the tumors. In general, IMP3 was more homogeneously expressed than L1CAM. IMP3 expression was significantly associated with advanced stage, nonendometrioid histology, grade 3 tumors, deep myometrial invasion, lymphovascular space invasion, distant recurrences, overall mortality, and disease-related mortality. Simultaneous absence of IMP3 and Ll CAM expression showed the highest accuracy for identifying low-grade carcinomas (area under the curve 0.766), whereas simultaneous expression of IMP3 and L1CAM was strongly associated with high-grade carcinomas (odds ratio 19.7; 95% confidence interval 9.2-42.2). Even within endometrioid carcinomas, this combination remained superior to IMP3 and L1CAM alone (odds ratio 8.6; 95% confidence interval 3.4-21.9). In conclusion, IMP3 has good diagnostic value and together with L1CAM represents the optimal combination of diagnostic markers for discrimination between low- and high-grade ECs compared to IMP3 and L1CAM alone. Because of the homogenous expression of IMP3, this marker might be valuable in preoperative biopsies when compared to the more patchy L1CAM expression. (C) 2019 Elsevier Inc. All rights reserved.
ER  -

VISSER, Nicole C. M., Louis J. M. VAN DER PUTTEN, Alex VAN EGERSCHOT, Koen K. VAN DE VIJVER, Maria SANTACANA, Peter BRONSERT, Marc HIRSCHFELD, Eva COLAS, Antonio GIL-MORENO, Angel GARCIA, Gemma MANCEBO, Francesc ALAMEDA, Camilla KRAKSTAD, Ingvild L. TANGEN, Jutta HUVILA, Stefanie SCHRAUWEN, Martin KOSKAS, Francine WALKER, Vít WEINBERGER, Luboš MINÁŘ, Jitka HAUSNEROVÁ, Marc P. L. M. SNIJDERS, Saskia VAN DEN BERG-VAN ERP, Xavier MATIAS-GUIU, Jone TROVIK, Frederic AMANT, Leon F. A. G. MASSUGER, Johan BULTEN and Johanna M. A. PIJNENBORG. Addition of IMP3 to L1CAM for discrimination between low- and high-grade endometrial carcinomas: a European Network for Individualised Treatment of Endometrial Cancer collaboration study. \textit{Human pathology}. Philadelphia, PA: W.B. Saunders Company, 2019, vol.~89, JUL 2019, p.~90-98. ISSN~0046-8177. Available from: https://dx.doi.org/10.1016/j.humpath.2019.04.014.

Detailed Information on Publication Record