Negative prognostic significance of primary cilia, CD8+tumor
infiltrating lymphocytes and PD1+cells expression in clear cell
renal cancer

J 2019

Negative prognostic significance of primary cilia, CD8+tumor infiltrating lymphocytes and PD1+cells expression in clear cell renal cancer

ROZSYPALOVA, Aneta, Blanka ROSOVA, Alzbeta FILIPOVA, Dimitar Hadzi NIKOLOV, Renata CHLOUPKOVÁ et. al.

Basic information

Original name

Negative prognostic significance of primary cilia, CD8+tumor infiltrating lymphocytes and PD1+cells expression in clear cell renal cancer

Authors

ROZSYPALOVA, Aneta (203 Czech Republic), Blanka ROSOVA (203 Czech Republic), Alzbeta FILIPOVA (203 Czech Republic), Dimitar Hadzi NIKOLOV (203 Czech Republic), Renata CHLOUPKOVÁ (203 Czech Republic, belonging to the institution), Igor RICHTER (203 Czech Republic), Jan PROKS (203 Czech Republic), Roman ZACHOVAL (203 Czech Republic), Radoslav MATEJ (203 Czech Republic), Bohuslav MELICHAR (203 Czech Republic), Tomas BUCHLER (203 Czech Republic) and Josef DVORAK (203 Czech Republic, guarantor)

Edition

Journal of BUON, Athens, ZERBINIS MEDICAL PUBL, 2019, 1107-0625

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

Greece

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 1.695

RIV identification code

RIV/00216224:14110/19:00108594

Organization unit

Faculty of Medicine

UT WoS

000481595900047

Keywords in English

clear cell renal cancer; primary cilia; CD8+tumor infiltrating lymphocytes; programmed cell death protein 1

Abstract

V originále

Purpose: The aim of this study was to investigate the potential association and combined prognostic significance of the frequency of primary cilia (PC), programmed cell death protein-1 receptor (PD1) and CD8+ tumor infiltrating lymphocytes (TIL) in patients with clear cell renal cancer (ccRCC). Methods: The frequency of PC, PD1 expression and the frequency of intratumoral CD8+ TIL were evaluated in 104 ccRCC patients. Results: The median frequency of PC was 0.003. The expression of PD1+ cells were <5% in 52 patients, 5-25% in 34 patients and 26-50% in 13 patients and >50% in 5 patients. Intratumoral CD8+ TIL were evaluable in all patients: negative in 1 patient, <25% in 63, 26-50% in 29 and >50% in 11 patients. Overall survival (OS) according to the frequency of PC was significantly shorter in patients with higher frequency (>= 0.002) than in patients with lower frequency (<0.002) (p<0.001). Median OS was significantly shorter in patients with higher (25%) CD8+ TIL and higher (>25%) PD1+ expression than in patients with lower (<25%) expression (4.6 vs. 97. years, p=0.006 and 2.9 vs. 8.9 years, p=0.006, respectively). Conclusions: The present study provides the first data on the potential association and combined prognostic significance of frequency of PC, PD1+ cells and CD8+ TIL in patients with clear cell renal cancer.

Links

NV15-34678A, research and development project

Name: Molekulární prognostické a prediktivní faktory u pacientů s metastatickým renálním karcinomem léčených tyrozinkinázovými inhibitory

Citovat

ROZSYPALOVA, Aneta, Blanka ROSOVA, Alzbeta FILIPOVA, Dimitar Hadzi NIKOLOV, Renata CHLOUPKOVÁ, Igor RICHTER, Jan PROKS, Roman ZACHOVAL, Radoslav MATEJ, Bohuslav MELICHAR, Tomas BUCHLER and Josef DVORAK. Negative prognostic significance of primary cilia, CD8+tumor infiltrating lymphocytes and PD1+cells expression in clear cell renal cancer. Journal of BUON. Athens: ZERBINIS MEDICAL PUBL, 2019, vol. 24, No 4, p. 1644-1651. ISSN 1107-0625.

@article{1622917,
   author = {Rozsypalova, Aneta and Rosova, Blanka and Filipova, Alzbeta and Nikolov, Dimitar Hadzi and Chloupková, Renata and Richter, Igor and Proks, Jan and Zachoval, Roman and Matej, Radoslav and Melichar, Bohuslav and Buchler, Tomas and Dvorak, Josef},
   article_location = {Athens},
   article_number = {4},
   keywords = {clear cell renal cancer; primary cilia; CD8+tumor infiltrating lymphocytes; programmed cell death protein 1},
   language = {eng},
   issn = {1107-0625},
   journal = {Journal of BUON},
   title = {Negative prognostic significance of primary cilia, CD8+tumor infiltrating lymphocytes and PD1+cells expression in clear cell renal cancer},
   url = {https://www.ncbi.nlm.nih.gov/pubmed/31646820},
   volume = {24},
   year = {2019}
}

TY  - JOUR
ID  - 1622917
AU  - Rozsypalova, Aneta - Rosova, Blanka - Filipova, Alzbeta - Nikolov, Dimitar Hadzi - Chloupková, Renata - Richter, Igor - Proks, Jan - Zachoval, Roman - Matej, Radoslav - Melichar, Bohuslav - Buchler, Tomas - Dvorak, Josef
PY  - 2019
TI  - Negative prognostic significance of primary cilia, CD8+tumor infiltrating lymphocytes and PD1+cells expression in clear cell renal cancer
JF  - Journal of BUON
VL  - 24
IS  - 4
SP  - 1644-1651
EP  - 1644-1651
PB  - ZERBINIS MEDICAL PUBL
SN  - 11070625
KW  - clear cell renal cancer
KW  - primary cilia
KW  - CD8+tumor infiltrating lymphocytes
KW  - programmed cell death protein 1
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31646820
L2  - https://www.ncbi.nlm.nih.gov/pubmed/31646820
N2  - Purpose: The aim of this study was to investigate the potential association and combined prognostic significance of the frequency of primary cilia (PC), programmed cell death protein-1 receptor (PD1) and CD8+ tumor infiltrating lymphocytes (TIL) in patients with clear cell renal cancer (ccRCC). Methods: The frequency of PC, PD1 expression and the frequency of intratumoral CD8+ TIL were evaluated in 104 ccRCC patients. Results: The median frequency of PC was 0.003. The expression of PD1+ cells were <5% in 52 patients, 5-25% in 34 patients and 26-50% in 13 patients and >50% in 5 patients. Intratumoral CD8+ TIL were evaluable in all patients: negative in 1 patient, <25% in 63, 26-50% in 29 and >50% in 11 patients. Overall survival (OS) according to the frequency of PC was significantly shorter in patients with higher frequency (>= 0.002) than in patients with lower frequency (<0.002) (p<0.001). Median OS was significantly shorter in patients with higher (25%) CD8+ TIL and higher (>25%) PD1+ expression than in patients with lower (<25%) expression (4.6 vs. 97. years, p=0.006 and 2.9 vs. 8.9 years, p=0.006, respectively). Conclusions: The present study provides the first data on the potential association and combined prognostic significance of frequency of PC, PD1+ cells and CD8+ TIL in patients with clear cell renal cancer.
ER  -

ROZSYPALOVA, Aneta, Blanka ROSOVA, Alzbeta FILIPOVA, Dimitar Hadzi NIKOLOV, Renata CHLOUPKOVÁ, Igor RICHTER, Jan PROKS, Roman ZACHOVAL, Radoslav MATEJ, Bohuslav MELICHAR, Tomas BUCHLER and Josef DVORAK. Negative prognostic significance of primary cilia, CD8+tumor infiltrating lymphocytes and PD1+cells expression in clear cell renal cancer. \textit{Journal of BUON}. Athens: ZERBINIS MEDICAL PUBL, 2019, vol.~24, No~4, p.~1644-1651. ISSN~1107-0625.

Detailed Information on Publication Record