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@article{1622977,
author = {Stejskalova, K. and Janova, E. and Horecky, C. and Horecka, E. and Vaclavek, P. and Hubalek, Z. and Relling, K. and Cvanová, Michaela and D'Amico, G. and Mihalca, A. D. and Modry, D. and Knoll, A. and Horin, P.},
article_location = {DORDRECHT},
article_number = {4},
doi = {http://dx.doi.org/10.1007/s11033-019-04900-w},
keywords = {West Nile virus; Horse; Restriction fragment length polymorphism; Microsatellite; SLC11A1; TLR4; MHC; NKR; Polymorphism},
language = {eng},
issn = {0301-4851},
journal = {MOLECULAR BIOLOGY REPORTS},
title = {Associations between the presence of specific antibodies to the West Nile Virus infection and candidate genes in Romanian horses from the Danube delta},
url = {http://dx.doi.org/10.1007/s11033-019-04900-w},
volume = {46},
year = {2019}
}
TY - JOUR
ID - 1622977
AU - Stejskalova, K. - Janova, E. - Horecky, C. - Horecka, E. - Vaclavek, P. - Hubalek, Z. - Relling, K. - Cvanová, Michaela - D'Amico, G. - Mihalca, A. D. - Modry, D. - Knoll, A. - Horin, P.
PY - 2019
TI - Associations between the presence of specific antibodies to the West Nile Virus infection and candidate genes in Romanian horses from the Danube delta
JF - MOLECULAR BIOLOGY REPORTS
VL - 46
IS - 4
SP - 4453-4461
EP - 4453-4461
PB - Springer
SN - 03014851
KW - West Nile virus
KW - Horse
KW - Restriction fragment length polymorphism
KW - Microsatellite
KW - SLC11A1
KW - TLR4
KW - MHC
KW - NKR
KW - Polymorphism
UR - http://dx.doi.org/10.1007/s11033-019-04900-w
L2 - http://dx.doi.org/10.1007/s11033-019-04900-w
N2 - The West Nile virus (WNV) is a mosquito-borne flavivirus causing meningoencephalitis in humans and animals. Due to their particular susceptibility to WNV infection, horses serve as a sentinel species. In a population of Romanian semi-feral horses living in the Danube delta region, we have analyzed the distribution of candidate polymorphic genetic markers between anti WNV-IgG seropositive and seronegative horses. Thirty-six SNPs located in 28 immunity-related genes and 26 microsatellites located in the MHC and LY49 complex genomic regions were genotyped in 57 seropositive and 32 seronegative horses. The most significant association (p(corr)<0.0002) was found for genotypes composed of markers of the SLC11A1 and TLR4 genes. Markers of five other candidate genes (ADAM17, CXCR3, IL12A, MAVS, TNFA), along with 5 MHC class I and LY49-linked microsatellites were also associated with the WNV antibody status in this model horse population. The OAS1 gene, previously associated with WNV-induced clinical disease, was not associated with the presence of anti-WNV antibodies.
ER -
STEJSKALOVA, K., E. JANOVA, C. HORECKY, E. HORECKA, P. VACLAVEK, Z. HUBALEK, K. RELLING, Michaela CVANOVÁ, G. D'AMICO, A. D. MIHALCA, D. MODRY, A. KNOLL a P. HORIN. Associations between the presence of specific antibodies to the West Nile Virus infection and candidate genes in Romanian horses from the Danube delta. \textit{MOLECULAR BIOLOGY REPORTS}. DORDRECHT: Springer, roč.~46, č.~4, s.~4453-4461. ISSN~0301-4851. doi:10.1007/s11033-019-04900-w. 2019.
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