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@article{1622977, author = {Stejskalova, K. and Janova, E. and Horecky, C. and Horecka, E. and Vaclavek, P. and Hubalek, Z. and Relling, K. and Cvanová, Michaela and D'Amico, G. and Mihalca, A. D. and Modry, D. and Knoll, A. and Horin, P.}, article_location = {DORDRECHT}, article_number = {4}, doi = {http://dx.doi.org/10.1007/s11033-019-04900-w}, keywords = {West Nile virus; Horse; Restriction fragment length polymorphism; Microsatellite; SLC11A1; TLR4; MHC; NKR; Polymorphism}, language = {eng}, issn = {0301-4851}, journal = {MOLECULAR BIOLOGY REPORTS}, title = {Associations between the presence of specific antibodies to the West Nile Virus infection and candidate genes in Romanian horses from the Danube delta}, url = {http://dx.doi.org/10.1007/s11033-019-04900-w}, volume = {46}, year = {2019} }
TY - JOUR ID - 1622977 AU - Stejskalova, K. - Janova, E. - Horecky, C. - Horecka, E. - Vaclavek, P. - Hubalek, Z. - Relling, K. - Cvanová, Michaela - D'Amico, G. - Mihalca, A. D. - Modry, D. - Knoll, A. - Horin, P. PY - 2019 TI - Associations between the presence of specific antibodies to the West Nile Virus infection and candidate genes in Romanian horses from the Danube delta JF - MOLECULAR BIOLOGY REPORTS VL - 46 IS - 4 SP - 4453-4461 EP - 4453-4461 PB - Springer SN - 03014851 KW - West Nile virus KW - Horse KW - Restriction fragment length polymorphism KW - Microsatellite KW - SLC11A1 KW - TLR4 KW - MHC KW - NKR KW - Polymorphism UR - http://dx.doi.org/10.1007/s11033-019-04900-w L2 - http://dx.doi.org/10.1007/s11033-019-04900-w N2 - The West Nile virus (WNV) is a mosquito-borne flavivirus causing meningoencephalitis in humans and animals. Due to their particular susceptibility to WNV infection, horses serve as a sentinel species. In a population of Romanian semi-feral horses living in the Danube delta region, we have analyzed the distribution of candidate polymorphic genetic markers between anti WNV-IgG seropositive and seronegative horses. Thirty-six SNPs located in 28 immunity-related genes and 26 microsatellites located in the MHC and LY49 complex genomic regions were genotyped in 57 seropositive and 32 seronegative horses. The most significant association (p(corr)<0.0002) was found for genotypes composed of markers of the SLC11A1 and TLR4 genes. Markers of five other candidate genes (ADAM17, CXCR3, IL12A, MAVS, TNFA), along with 5 MHC class I and LY49-linked microsatellites were also associated with the WNV antibody status in this model horse population. The OAS1 gene, previously associated with WNV-induced clinical disease, was not associated with the presence of anti-WNV antibodies. ER -
STEJSKALOVA, K., E. JANOVA, C. HORECKY, E. HORECKA, P. VACLAVEK, Z. HUBALEK, K. RELLING, Michaela CVANOVÁ, G. D'AMICO, A. D. MIHALCA, D. MODRY, A. KNOLL and P. HORIN. Associations between the presence of specific antibodies to the West Nile Virus infection and candidate genes in Romanian horses from the Danube delta. \textit{MOLECULAR BIOLOGY REPORTS}. DORDRECHT: Springer, 2019, vol.~46, No~4, p.~4453-4461. ISSN~0301-4851. Available from: https://dx.doi.org/10.1007/s11033-019-04900-w.
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