| ZAVESKY, Ludek, Eva JANDÁKOVÁ, Vít WEINBERGER, Luboš MINÁŘ, Veronika HANZIKOVA, Daniela DUSKOVA, Lenka ZAVESKA DRABKOVA and Ales HORINEK. Ovarian Cancer: Differentially Expressed microRNAs in Tumor Tissue and Cell-Free Ascitic Fluid as Potential Novel Biomarkers. Cancer Investigation. PHILADELPHIA: TAYLOR & FRANCIS, 2019, vol. 37, No 9, p. 440-452. ISSN 0735-7907. Available from: https://dx.doi.org/10.1080/07357907.2019.1663208. |
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@article{1623056,
author = {Zavesky, Ludek and Jandáková, Eva and Weinberger, Vít and Minář, Luboš and Hanzikova, Veronika and Duskova, Daniela and Zaveska Drabkova, Lenka and Horinek, Ales},
article_location = {PHILADELPHIA},
article_number = {9},
doi = {http://dx.doi.org/10.1080/07357907.2019.1663208},
keywords = {Ovarian cancer; ascites; effusion; microRNA; tumor},
language = {eng},
issn = {0735-7907},
journal = {Cancer Investigation},
title = {Ovarian Cancer: Differentially Expressed microRNAs in Tumor Tissue and Cell-Free Ascitic Fluid as Potential Novel Biomarkers},
url = {http://dx.doi.org/10.1080/07357907.2019.1663208},
volume = {37},
year = {2019}
}
TY - JOUR
ID - 1623056
AU - Zavesky, Ludek - Jandáková, Eva - Weinberger, Vít - Minář, Luboš - Hanzikova, Veronika - Duskova, Daniela - Zaveska Drabkova, Lenka - Horinek, Ales
PY - 2019
TI - Ovarian Cancer: Differentially Expressed microRNAs in Tumor Tissue and Cell-Free Ascitic Fluid as Potential Novel Biomarkers
JF - Cancer Investigation
VL - 37
IS - 9
SP - 440-452
EP - 440-452
PB - TAYLOR & FRANCIS
SN - 07357907
KW - Ovarian cancer
KW - ascites
KW - effusion
KW - microRNA
KW - tumor
UR - http://dx.doi.org/10.1080/07357907.2019.1663208
L2 - http://dx.doi.org/10.1080/07357907.2019.1663208
N2 - Ovarian cancer is the deadliest gynecologic cancer. The large-scale microRNA (miRNA) expression profiling and individual miRNA validation was performed to find potential novel biomarkers for ovarian cancer. The most consistent overexpression of miRs-200b-3p, 135 b-5p and 182-5p was found in both ascitic fluid and tumors and suggests their potential as oncogenes. miR-451a was consistently underexpressed so may be a tumor suppressor. Results were inconsistent for miR-204-5p, which was overexpressed in ascitic fluid but underexpressed in tumor tissue. miR-203a-3p was generally overexpressed but this failed to be proved in independent sample set in tissue validation.
ER -
ZAVESKY, Ludek, Eva JANDÁKOVÁ, Vít WEINBERGER, Luboš MINÁŘ, Veronika HANZIKOVA, Daniela DUSKOVA, Lenka ZAVESKA DRABKOVA and Ales HORINEK. Ovarian Cancer: Differentially Expressed microRNAs in Tumor Tissue and Cell-Free Ascitic Fluid as Potential Novel Biomarkers. \textit{Cancer Investigation}. PHILADELPHIA: TAYLOR \&{} FRANCIS, 2019, vol.~37, No~9, p.~440-452. ISSN~0735-7907. Available from: https://dx.doi.org/10.1080/07357907.2019.1663208.
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