Ovarian Cancer: Differentially Expressed microRNAs in Tumor
Tissue and Cell-Free Ascitic Fluid as Potential Novel
Biomarkers

J 2019

Ovarian Cancer: Differentially Expressed microRNAs in Tumor Tissue and Cell-Free Ascitic Fluid as Potential Novel Biomarkers

ZAVESKY, Ludek, Eva JANDÁKOVÁ, Vít WEINBERGER, Luboš MINÁŘ, Veronika HANZIKOVA et. al.

Basic information

Original name

Ovarian Cancer: Differentially Expressed microRNAs in Tumor Tissue and Cell-Free Ascitic Fluid as Potential Novel Biomarkers

Authors

ZAVESKY, Ludek (203 Czech Republic, guarantor), Eva JANDÁKOVÁ (203 Czech Republic, belonging to the institution), Vít WEINBERGER (203 Czech Republic, belonging to the institution), Luboš MINÁŘ (203 Czech Republic, belonging to the institution), Veronika HANZIKOVA (203 Czech Republic), Daniela DUSKOVA (203 Czech Republic), Lenka ZAVESKA DRABKOVA (203 Czech Republic) and Ales HORINEK (203 Czech Republic)

Edition

Cancer Investigation, PHILADELPHIA, TAYLOR & FRANCIS, 2019, 0735-7907

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.398

RIV identification code

RIV/00216224:14110/19:00112959

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1080/07357907.2019.1663208

UT WoS

000486781600001

Keywords in English

Ovarian cancer; ascites; effusion; microRNA; tumor

Abstract

V originále

Ovarian cancer is the deadliest gynecologic cancer. The large-scale microRNA (miRNA) expression profiling and individual miRNA validation was performed to find potential novel biomarkers for ovarian cancer. The most consistent overexpression of miRs-200b-3p, 135 b-5p and 182-5p was found in both ascitic fluid and tumors and suggests their potential as oncogenes. miR-451a was consistently underexpressed so may be a tumor suppressor. Results were inconsistent for miR-204-5p, which was overexpressed in ascitic fluid but underexpressed in tumor tissue. miR-203a-3p was generally overexpressed but this failed to be proved in independent sample set in tissue validation.

Citovat

ZAVESKY, Ludek, Eva JANDÁKOVÁ, Vít WEINBERGER, Luboš MINÁŘ, Veronika HANZIKOVA, Daniela DUSKOVA, Lenka ZAVESKA DRABKOVA and Ales HORINEK. Ovarian Cancer: Differentially Expressed microRNAs in Tumor Tissue and Cell-Free Ascitic Fluid as Potential Novel Biomarkers. Cancer Investigation. PHILADELPHIA: TAYLOR & FRANCIS, 2019, vol. 37, No 9, p. 440-452. ISSN 0735-7907. Available from: https://dx.doi.org/10.1080/07357907.2019.1663208.

@article{1623056,
   author = {Zavesky, Ludek and Jandáková, Eva and Weinberger, Vít and Minář, Luboš and Hanzikova, Veronika and Duskova, Daniela and Zaveska Drabkova, Lenka and Horinek, Ales},
   article_location = {PHILADELPHIA},
   article_number = {9},
   doi = {http://dx.doi.org/10.1080/07357907.2019.1663208},
   keywords = {Ovarian cancer; ascites; effusion; microRNA; tumor},
   language = {eng},
   issn = {0735-7907},
   journal = {Cancer Investigation},
   title = {Ovarian Cancer: Differentially Expressed microRNAs in Tumor Tissue and Cell-Free Ascitic Fluid as Potential Novel Biomarkers},
   url = {http://dx.doi.org/10.1080/07357907.2019.1663208},
   volume = {37},
   year = {2019}
}

TY  - JOUR
ID  - 1623056
AU  - Zavesky, Ludek - Jandáková, Eva - Weinberger, Vít - Minář, Luboš - Hanzikova, Veronika - Duskova, Daniela - Zaveska Drabkova, Lenka - Horinek, Ales
PY  - 2019
TI  - Ovarian Cancer: Differentially Expressed microRNAs in Tumor Tissue and Cell-Free Ascitic Fluid as Potential Novel Biomarkers
JF  - Cancer Investigation
VL  - 37
IS  - 9
SP  - 440-452
EP  - 440-452
PB  - TAYLOR & FRANCIS
SN  - 07357907
KW  - Ovarian cancer
KW  - ascites
KW  - effusion
KW  - microRNA
KW  - tumor
UR  - http://dx.doi.org/10.1080/07357907.2019.1663208
L2  - http://dx.doi.org/10.1080/07357907.2019.1663208
N2  - Ovarian cancer is the deadliest gynecologic cancer. The large-scale microRNA (miRNA) expression profiling and individual miRNA validation was performed to find potential novel biomarkers for ovarian cancer. The most consistent overexpression of miRs-200b-3p, 135 b-5p and 182-5p was found in both ascitic fluid and tumors and suggests their potential as oncogenes. miR-451a was consistently underexpressed so may be a tumor suppressor. Results were inconsistent for miR-204-5p, which was overexpressed in ascitic fluid but underexpressed in tumor tissue. miR-203a-3p was generally overexpressed but this failed to be proved in independent sample set in tissue validation.
ER  -

ZAVESKY, Ludek, Eva JANDÁKOVÁ, Vít WEINBERGER, Luboš MINÁŘ, Veronika HANZIKOVA, Daniela DUSKOVA, Lenka ZAVESKA DRABKOVA and Ales HORINEK. Ovarian Cancer: Differentially Expressed microRNAs in Tumor Tissue and Cell-Free Ascitic Fluid as Potential Novel Biomarkers. \textit{Cancer Investigation}. PHILADELPHIA: TAYLOR \&{} FRANCIS, 2019, vol.~37, No~9, p.~440-452. ISSN~0735-7907. Available from: https://dx.doi.org/10.1080/07357907.2019.1663208.

Detailed Information on Publication Record