| JIRIK, Radovan, Torfinn TAXT, Ondrej MACICEK, Michal BARTOS, Jiri KRATOCHVILA, Karel SOUČEK, Eva DRAZANOVA, Lucie KRATKA, Aleš HAMPL and Zenon, Jr. STARCUK. Blind deconvolution estimation of an arterial input function for small animal DCE-MRI. MAGNETIC RESONANCE IMAGING. NEW YORK: ELSEVIER SCIENCE INC, 2019, vol. 62, OCT 2019, p. 46-56. ISSN 0730-725X. Available from: https://dx.doi.org/10.1016/j.mri.2019.05.024. |
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@article{1623076,
author = {Jirik, Radovan and Taxt, Torfinn and Macicek, Ondrej and Bartos, Michal and Kratochvila, Jiri and Souček, Karel and Drazanova, Eva and Kratka, Lucie and Hampl, Aleš and Starcuk, Zenon, Jr.},
article_location = {NEW YORK},
article_number = {OCT 2019},
doi = {http://dx.doi.org/10.1016/j.mri.2019.05.024},
keywords = {DCE-MRI; Blind deconvolution; Arterial input function},
language = {eng},
issn = {0730-725X},
journal = {MAGNETIC RESONANCE IMAGING},
title = {Blind deconvolution estimation of an arterial input function for small animal DCE-MRI},
url = {http://dx.doi.org/10.1016/j.mri.2019.05.024},
volume = {62},
year = {2019}
}
TY - JOUR
ID - 1623076
AU - Jirik, Radovan - Taxt, Torfinn - Macicek, Ondrej - Bartos, Michal - Kratochvila, Jiri - Souček, Karel - Drazanova, Eva - Kratka, Lucie - Hampl, Aleš - Starcuk, Zenon, Jr.
PY - 2019
TI - Blind deconvolution estimation of an arterial input function for small animal DCE-MRI
JF - MAGNETIC RESONANCE IMAGING
VL - 62
IS - OCT 2019
SP - 46-56
EP - 46-56
PB - ELSEVIER SCIENCE INC
SN - 0730725X
KW - DCE-MRI
KW - Blind deconvolution
KW - Arterial input function
UR - http://dx.doi.org/10.1016/j.mri.2019.05.024
L2 - http://dx.doi.org/10.1016/j.mri.2019.05.024
N2 - Purpose: One of the main obstacles for reliable quantitative dynamic contrast-enhanced (DCE) MRI is the need for accurate knowledge of the arterial input function (AIF). This is a special challenge for preclinical small animal applications where it is very difficult to measure the AIF without partial volume and flow artifacts. Furthermore, using advanced pharmacokinetic models (allowing estimation of blood flow and permeability surface area product in addition to the classical perfusion parameters) poses stricter requirements on the accuracy and precision of AIF estimation. This paper addresses small animal DCE-MRI with advanced pharmacokinetic models and presents a method for estimation of the AIF based on blind deconvolution. Methods: A parametric AIF model designed for small animal physiology and use of advanced pharmacokinetic models is proposed. The parameters of the AIF are estimated using multichannel blind deconvolution. Results: Evaluation on simulated data show that for realistic signal to noise ratios blind deconvolution AIF estimation leads to comparable results as the use of the true AIF. Evaluation on real data based on DCE-MRI with two contrast agents of different molecular weights showed a consistence with the known effects of the molecular weight. Conclusion: Multi-channel blind deconvolution using the proposed AIF model specific for small animal DCE-MRI provides reliable perfusion parameter estimates under realistic signal to noise conditions.
ER -
JIRIK, Radovan, Torfinn TAXT, Ondrej MACICEK, Michal BARTOS, Jiri KRATOCHVILA, Karel SOUČEK, Eva DRAZANOVA, Lucie KRATKA, Aleš HAMPL and Zenon, Jr. STARCUK. Blind deconvolution estimation of an arterial input function for small animal DCE-MRI. \textit{MAGNETIC RESONANCE IMAGING}. NEW YORK: ELSEVIER SCIENCE INC, 2019, vol.~62, OCT 2019, p.~46-56. ISSN~0730-725X. Available from: https://dx.doi.org/10.1016/j.mri.2019.05.024.
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