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@article{1623257,
author = {Stehlikova, Zuzana and Tlaskal, Vojtech and Galanova, Natalie and Roubalova, Radka and Kreisinger, Jakub and Dvorak, Jiri and Prochazkova, Petra and Kostovcikova, Klara and Bartova, Jirina and Libanska, Marketa and Cermakova, Radka and Schierova, Dagmar and Fassmann, Antonín and Bořilová Linhartová, Petra and Coufal, Stepan and Kverka, Miloslav and Izakovičová Hollá, Lydie and Petanova, Jitka and TlaskalovaandHogenova, Helena and Jiraskova Zakostelska, Zuzana},
article_location = {Basel},
article_number = {12},
doi = {http://dx.doi.org/10.3390/microorganisms7120636},
keywords = {microbiome; mycobiome; oral mucosa},
language = {eng},
issn = {2076-2607},
journal = {Microorganisms},
title = {Oral Microbiota Composition and Antimicrobial Antibody Response in Patients with Recurrent Aphthous Stomatitis},
url = {http://dx.doi.org/10.3390/microorganisms7120636},
volume = {7},
year = {2019}
}
TY - JOUR
ID - 1623257
AU - Stehlikova, Zuzana - Tlaskal, Vojtech - Galanova, Natalie - Roubalova, Radka - Kreisinger, Jakub - Dvorak, Jiri - Prochazkova, Petra - Kostovcikova, Klara - Bartova, Jirina - Libanska, Marketa - Cermakova, Radka - Schierova, Dagmar - Fassmann, Antonín - Bořilová Linhartová, Petra - Coufal, Stepan - Kverka, Miloslav - Izakovičová Hollá, Lydie - Petanova, Jitka - Tlaskalova-Hogenova, Helena - Jiraskova Zakostelska, Zuzana
PY - 2019
TI - Oral Microbiota Composition and Antimicrobial Antibody Response in Patients with Recurrent Aphthous Stomatitis
JF - Microorganisms
VL - 7
IS - 12
SP - 1-14
EP - 1-14
PB - MDPI
SN - 20762607
KW - microbiome
KW - mycobiome
KW - oral mucosa
UR - http://dx.doi.org/10.3390/microorganisms7120636
L2 - http://dx.doi.org/10.3390/microorganisms7120636
N2 - Recurrent aphthous stomatitis (RAS) is the most common disease of the oral mucosa, and it has been recently associated with bacterial and fungal dysbiosis. To study this link further, we investigated microbial shifts during RAS manifestation at an ulcer site, in its surroundings, and at an unaffected site, compared with healed mucosa in RAS patients and healthy controls. We sampled microbes from five distinct sites in the oral cavity. The one site with the most pronounced differences in microbial alpha and beta diversity between RAS patients and healthy controls was the lower labial mucosa. Detailed analysis of this particular oral site revealed strict association of the genus Selenomonas with healed mucosa of RAS patients, whereas the class Clostridia and genera Lachnoanaerobaculum, Cardiobacterium, Leptotrichia, and Fusobacterium were associated with the presence of an active ulcer. Furthermore, active ulcers were dominated by Malassezia, which were negatively correlated with Streptococcus and Haemophilus and positively correlated with Porphyromonas species. In addition, RAS patients showed increased serum levels of IgG against Mogibacterium timidum compared with healthy controls. Our study demonstrates that the composition of bacteria and fungi colonizing healthy oral mucosa is changed in active RAS ulcers, and that this alteration persists to some extent even after the ulcer is healed.
ER -
STEHLIKOVA, Zuzana, Vojtech TLASKAL, Natalie GALANOVA, Radka ROUBALOVA, Jakub KREISINGER, Jiri DVORAK, Petra PROCHAZKOVA, Klara KOSTOVCIKOVA, Jirina BARTOVA, Marketa LIBANSKA, Radka CERMAKOVA, Dagmar SCHIEROVA, Antonín FASSMANN, Petra BOŘILOVÁ LINHARTOVÁ, Stepan COUFAL, Miloslav KVERKA, Lydie IZAKOVIČOVÁ HOLLÁ, Jitka PETANOVA, Helena TLASKALOVA-HOGENOVA and Zuzana JIRASKOVA ZAKOSTELSKA. Oral Microbiota Composition and Antimicrobial Antibody Response in Patients with Recurrent Aphthous Stomatitis. \textit{Microorganisms}. Basel: MDPI, 2019, vol.~7, No~12, p.~1-14. ISSN~2076-2607. Available from: https://dx.doi.org/10.3390/microorganisms7120636.
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