| JANKŮ, Petr, Marian KACEROVSKY, Barbora ZEDNIKOVA, Ctirad ANDRYS, Martina KOLACKOVA, Marcela DRAHOSOVA, Lenka PLISKOVA, Helena ZEMLICKOVA, Romana GERYCHOVÁ, Ondrej SIMETKA, Petr MATLAK, Bo JACOBSSON and Ivana MUSILOVA. Pentraxin 3 in Noninvasively Obtained Cervical Fluid Samples from Pregnancies Complicated by Preterm Prelabor Rupture of Membranes. Fetal Diagnosis and Therapy. Basel: Karger, 2019, vol. 46, No 6, p. 402-410. ISSN 1015-3837. Available from: https://dx.doi.org/10.1159/000499482. |
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@article{1623276,
author = {Janků, Petr and Kacerovsky, Marian and Zednikova, Barbora and Andrys, Ctirad and Kolackova, Martina and Drahosova, Marcela and Pliskova, Lenka and Zemlickova, Helena and Gerychová, Romana and Simetka, Ondrej and Matlak, Petr and Jacobsson, Bo and Musilova, Ivana},
article_location = {Basel},
article_number = {6},
doi = {http://dx.doi.org/10.1159/000499482},
keywords = {Inflammation; Microorganism; Pattern recognition receptor; Preterm birth},
language = {eng},
issn = {1015-3837},
journal = {Fetal Diagnosis and Therapy},
title = {Pentraxin 3 in Noninvasively Obtained Cervical Fluid Samples from Pregnancies Complicated by Preterm Prelabor Rupture of Membranes},
url = {http://dx.doi.org/10.1159/000499482},
volume = {46},
year = {2019}
}
TY - JOUR
ID - 1623276
AU - Janků, Petr - Kacerovsky, Marian - Zednikova, Barbora - Andrys, Ctirad - Kolackova, Martina - Drahosova, Marcela - Pliskova, Lenka - Zemlickova, Helena - Gerychová, Romana - Simetka, Ondrej - Matlak, Petr - Jacobsson, Bo - Musilova, Ivana
PY - 2019
TI - Pentraxin 3 in Noninvasively Obtained Cervical Fluid Samples from Pregnancies Complicated by Preterm Prelabor Rupture of Membranes
JF - Fetal Diagnosis and Therapy
VL - 46
IS - 6
SP - 402-410
EP - 402-410
PB - Karger
SN - 10153837
KW - Inflammation
KW - Microorganism
KW - Pattern recognition receptor
KW - Preterm birth
UR - http://dx.doi.org/10.1159/000499482
L2 - http://dx.doi.org/10.1159/000499482
N2 - Problem: To determine the changes of pentraxin 3 (PTX3) level in noninvasively obtained cervical fluid samples from women with preterm prelabor rupture of membranes (PPROM) based on the presence of microbial invasion of the amniotic cavity (MIAC) and/or intra-amniotic inflammation (IAI), and intra-amniotic infection (the presence of both MIAC and IAI). Methods of Study: A total of 160 women with PPROM were included. Cervical fluid samples were obtained using a Dacron polyester swab and amniotic fluid samples were obtained by transabdominal amniocentesis. Cervical fluid PTX3 levels were assessed using enzyme-linked immunosorbent assay. Results: PTX3 was found in all the cervical fluid samples and its levels were higher in women with MIAC, IAI, and intra-amniotic infection than in women without these conditions. When the women were categorized into four subgroups based on the presence of MIAC and/or IAI, women with intra-amniotic infection had higher cervical fluid PTX3 levels than those with sterile IAI (IAI alone), colonization (MIAC alone), or no MIAC or IAI. A cervical fluid PTX3 level of 11 ng/mL was the best value for identifying the presence of intra-amniotic infection in women with PPROM. Conclusions: PTX3 is a constituent of cervical fluid of women with PPROM. Cervical fluid PTX3 level reflects the situation in the intra-amniotic compartments of women with PPROM. Cervical fluid PTX3 is a potential marker for the noninvasive identification of intra-amniotic infection in PPROM.
ER -
JANKŮ, Petr, Marian KACEROVSKY, Barbora ZEDNIKOVA, Ctirad ANDRYS, Martina KOLACKOVA, Marcela DRAHOSOVA, Lenka PLISKOVA, Helena ZEMLICKOVA, Romana GERYCHOVÁ, Ondrej SIMETKA, Petr MATLAK, Bo JACOBSSON and Ivana MUSILOVA. Pentraxin 3 in Noninvasively Obtained Cervical Fluid Samples from Pregnancies Complicated by Preterm Prelabor Rupture of Membranes. \textit{Fetal Diagnosis and Therapy}. Basel: Karger, 2019, vol.~46, No~6, p.~402-410. ISSN~1015-3837. Available from: https://dx.doi.org/10.1159/000499482.
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