Pentraxin 3 in Noninvasively Obtained Cervical Fluid Samples
from Pregnancies Complicated by Preterm Prelabor Rupture of
Membranes

J 2019

Pentraxin 3 in Noninvasively Obtained Cervical Fluid Samples from Pregnancies Complicated by Preterm Prelabor Rupture of Membranes

JANKŮ, Petr, Marian KACEROVSKY, Barbora ZEDNIKOVA, Ctirad ANDRYS, Martina KOLACKOVA et. al.

Basic information

Original name

Pentraxin 3 in Noninvasively Obtained Cervical Fluid Samples from Pregnancies Complicated by Preterm Prelabor Rupture of Membranes

Authors

JANKŮ, Petr (203 Czech Republic, belonging to the institution), Marian KACEROVSKY (203 Czech Republic, guarantor), Barbora ZEDNIKOVA (203 Czech Republic), Ctirad ANDRYS (203 Czech Republic), Martina KOLACKOVA (203 Czech Republic), Marcela DRAHOSOVA (203 Czech Republic), Lenka PLISKOVA (203 Czech Republic), Helena ZEMLICKOVA (203 Czech Republic), Romana GERYCHOVÁ (203 Czech Republic, belonging to the institution), Ondrej SIMETKA (203 Czech Republic), Petr MATLAK (203 Czech Republic), Bo JACOBSSON (752 Sweden) and Ivana MUSILOVA (203 Czech Republic)

Edition

Fetal Diagnosis and Therapy, Basel, Karger, 2019, 1015-3837

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30214 Obstetrics and gynaecology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.095

RIV identification code

RIV/00216224:14110/19:00112965

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1159/000499482

UT WoS

000507387300007

Keywords in English

Inflammation; Microorganism; Pattern recognition receptor; Preterm birth

Abstract

V originále

Problem: To determine the changes of pentraxin 3 (PTX3) level in noninvasively obtained cervical fluid samples from women with preterm prelabor rupture of membranes (PPROM) based on the presence of microbial invasion of the amniotic cavity (MIAC) and/or intra-amniotic inflammation (IAI), and intra-amniotic infection (the presence of both MIAC and IAI). Methods of Study: A total of 160 women with PPROM were included. Cervical fluid samples were obtained using a Dacron polyester swab and amniotic fluid samples were obtained by transabdominal amniocentesis. Cervical fluid PTX3 levels were assessed using enzyme-linked immunosorbent assay. Results: PTX3 was found in all the cervical fluid samples and its levels were higher in women with MIAC, IAI, and intra-amniotic infection than in women without these conditions. When the women were categorized into four subgroups based on the presence of MIAC and/or IAI, women with intra-amniotic infection had higher cervical fluid PTX3 levels than those with sterile IAI (IAI alone), colonization (MIAC alone), or no MIAC or IAI. A cervical fluid PTX3 level of 11 ng/mL was the best value for identifying the presence of intra-amniotic infection in women with PPROM. Conclusions: PTX3 is a constituent of cervical fluid of women with PPROM. Cervical fluid PTX3 level reflects the situation in the intra-amniotic compartments of women with PPROM. Cervical fluid PTX3 is a potential marker for the noninvasive identification of intra-amniotic infection in PPROM.

Citovat

JANKŮ, Petr, Marian KACEROVSKY, Barbora ZEDNIKOVA, Ctirad ANDRYS, Martina KOLACKOVA, Marcela DRAHOSOVA, Lenka PLISKOVA, Helena ZEMLICKOVA, Romana GERYCHOVÁ, Ondrej SIMETKA, Petr MATLAK, Bo JACOBSSON and Ivana MUSILOVA. Pentraxin 3 in Noninvasively Obtained Cervical Fluid Samples from Pregnancies Complicated by Preterm Prelabor Rupture of Membranes. Fetal Diagnosis and Therapy. Basel: Karger, 2019, vol. 46, No 6, p. 402-410. ISSN 1015-3837. Available from: https://dx.doi.org/10.1159/000499482.

@article{1623276,
   author = {Janků, Petr and Kacerovsky, Marian and Zednikova, Barbora and Andrys, Ctirad and Kolackova, Martina and Drahosova, Marcela and Pliskova, Lenka and Zemlickova, Helena and Gerychová, Romana and Simetka, Ondrej and Matlak, Petr and Jacobsson, Bo and Musilova, Ivana},
   article_location = {Basel},
   article_number = {6},
   doi = {http://dx.doi.org/10.1159/000499482},
   keywords = {Inflammation; Microorganism; Pattern recognition receptor; Preterm birth},
   language = {eng},
   issn = {1015-3837},
   journal = {Fetal Diagnosis and Therapy},
   title = {Pentraxin 3 in Noninvasively Obtained Cervical Fluid Samples from Pregnancies Complicated by Preterm Prelabor Rupture of Membranes},
   url = {http://dx.doi.org/10.1159/000499482},
   volume = {46},
   year = {2019}
}

TY  - JOUR
ID  - 1623276
AU  - Janků, Petr - Kacerovsky, Marian - Zednikova, Barbora - Andrys, Ctirad - Kolackova, Martina - Drahosova, Marcela - Pliskova, Lenka - Zemlickova, Helena - Gerychová, Romana - Simetka, Ondrej - Matlak, Petr - Jacobsson, Bo - Musilova, Ivana
PY  - 2019
TI  - Pentraxin 3 in Noninvasively Obtained Cervical Fluid Samples from Pregnancies Complicated by Preterm Prelabor Rupture of Membranes
JF  - Fetal Diagnosis and Therapy
VL  - 46
IS  - 6
SP  - 402-410
EP  - 402-410
PB  - Karger
SN  - 10153837
KW  - Inflammation
KW  - Microorganism
KW  - Pattern recognition receptor
KW  - Preterm birth
UR  - http://dx.doi.org/10.1159/000499482
L2  - http://dx.doi.org/10.1159/000499482
N2  - Problem: To determine the changes of pentraxin 3 (PTX3) level in noninvasively obtained cervical fluid samples from women with preterm prelabor rupture of membranes (PPROM) based on the presence of microbial invasion of the amniotic cavity (MIAC) and/or intra-amniotic inflammation (IAI), and intra-amniotic infection (the presence of both MIAC and IAI). Methods of Study: A total of 160 women with PPROM were included. Cervical fluid samples were obtained using a Dacron polyester swab and amniotic fluid samples were obtained by transabdominal amniocentesis. Cervical fluid PTX3 levels were assessed using enzyme-linked immunosorbent assay. Results: PTX3 was found in all the cervical fluid samples and its levels were higher in women with MIAC, IAI, and intra-amniotic infection than in women without these conditions. When the women were categorized into four subgroups based on the presence of MIAC and/or IAI, women with intra-amniotic infection had higher cervical fluid PTX3 levels than those with sterile IAI (IAI alone), colonization (MIAC alone), or no MIAC or IAI. A cervical fluid PTX3 level of 11 ng/mL was the best value for identifying the presence of intra-amniotic infection in women with PPROM. Conclusions: PTX3 is a constituent of cervical fluid of women with PPROM. Cervical fluid PTX3 level reflects the situation in the intra-amniotic compartments of women with PPROM. Cervical fluid PTX3 is a potential marker for the noninvasive identification of intra-amniotic infection in PPROM.
ER  -

JANKŮ, Petr, Marian KACEROVSKY, Barbora ZEDNIKOVA, Ctirad ANDRYS, Martina KOLACKOVA, Marcela DRAHOSOVA, Lenka PLISKOVA, Helena ZEMLICKOVA, Romana GERYCHOVÁ, Ondrej SIMETKA, Petr MATLAK, Bo JACOBSSON and Ivana MUSILOVA. Pentraxin 3 in Noninvasively Obtained Cervical Fluid Samples from Pregnancies Complicated by Preterm Prelabor Rupture of Membranes. \textit{Fetal Diagnosis and Therapy}. Basel: Karger, 2019, vol.~46, No~6, p.~402-410. ISSN~1015-3837. Available from: https://dx.doi.org/10.1159/000499482.

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