Sex and race differences in J-Tend, J-Tpeak, and Tpeak-Tend intervals

HNATKOVA, Katerina, Ondřej TOMAN, Martina ŠIŠÁKOVÁ, Peter SMETANA, Katharina M. HUSTER, Petra BARTHEL, Tomáš NOVOTNÝ, Georg SCHMIDT and Marek MALIK. Sex and race differences in J-Tend, J-Tpeak, and Tpeak-Tend intervals. Scientific reports. LONDON: NATURE PUBLISHING GROUP, 2019, vol. 9, DEC 27 2019, p. 1-16. ISSN 2045-2322. Available from: https://dx.doi.org/10.1038/s41598-019-56328-8.

Basic information

• Original name: Sex and race differences in J-Tend, J-Tpeak, and Tpeak-Tend intervals
• Authors: HNATKOVA, Katerina (826 United Kingdom of Great Britain and Northern Ireland), Ondřej TOMAN (203 Czech Republic, belonging to the institution), Martina ŠIŠÁKOVÁ (203 Czech Republic, belonging to the institution), Peter SMETANA (40 Austria), Katharina M. HUSTER (276 Germany), Petra BARTHEL (276 Germany), Tomáš NOVOTNÝ (203 Czech Republic, belonging to the institution), Georg SCHMIDT (276 Germany) and Marek MALIK (826 United Kingdom of Great Britain and Northern Ireland, guarantor).
• Edition: Scientific reports, LONDON, NATURE PUBLISHING GROUP, 2019, 2045-2322.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30201 Cardiac and Cardiovascular systems
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 3.998
• RIV identification code: RIV/00216224:14110/19:00112966
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1038/s41598-019-56328-8
• UT WoS: 000508960600003
• Keywords in English: QT INTERVAL; HEART-RATE; HEALTHY-SUBJECTS; SAMPLE-SIZE; THOROUGH; MORTALITY; BLOCK
• Tags: 14110211, rivok
• Tags: International impact, Reviewed

Abstract

To facilitate the precision of clinical electrocardiographic studies of J-to-Tpeak (JTp) and Tpeak-to-Tend (Tpe) intervals, the study investigated their differences between healthy females and males, and between subjects of African and Caucasian origin. In 523 healthy subjects (254 females; 236 subjects of African origin), repeated Holter recordings were used to measure QT, JT, JTp, and Tpe intervals preceded by both stable and variable heart rates. Subject-specific curvilinear regression models were used to obtain individual QTc, JTc, JTpc and Tpec intervals. Rate hysteresis, i.e., the speed with which the intervals adapted after heart rate changes, was also investigated. In all sex-race groups, Tpe intervals were not systematically heart rate dependent. Similar to QTc intervals, women had JTc, and JTpc intervals longer than males (difference 20-30 ms, p < 0.001). However, women had Tpec intervals (and rate uncorrected Tpe intervals) shorter by approximately 10 ms compared to males (p < 0.001). Subjects of African origin had significantly shorter QTc intervals than Caucasians (p < 0.001). Gradually diminishing race-difference was found for JTc, JTpc and Tpec intervals. JTc and JTpc were moderately increasing with age but Tpe/Tpec were not. Rate hysteresis of JTp was approximately 10% longer compared to that of JT (p < 0.001). In future clinical studies, Tpe interval should not be systematically corrected for heart rate and similar to the QT interval, the differences in JT, JTp and Tpe intervals should be corrected for sex. The differences in QT and JT, and JTp intervals should also be corrected for race.