Podrobný výpis o publikaci

ZIMTA, A.A., A.B. TIGU, M. MUNTEAN, D. CENARIU, Ondřej SLABÝ a I. BERINDAN-NEAGOE. Molecular Links between Central Obesity and Breast Cancer. International Journal of Molecular Sciences. Basel: Multidisciplinary Digital Publishing Institute, 2019, roč. 20, č. 21, s. 5364-5384. ISSN 1422-0067. Dostupné z: https://dx.doi.org/10.3390/ijms20215364.

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Základní údaje
Originální název	Molecular Links between Central Obesity and Breast Cancer
Autoři	ZIMTA, A.A. (642 Rumunsko), A.B. TIGU (642 Rumunsko), M. MUNTEAN (642 Rumunsko), D. CENARIU (642 Rumunsko), Ondřej SLABÝ (203 Česká republika, garant, domácí) a I. BERINDAN-NEAGOE (642 Rumunsko).
Vydání	International Journal of Molecular Sciences, Basel, Multidisciplinary Digital Publishing Institute, 2019, 1422-0067.

Další údaje
Originální jazyk	angličtina
Typ výsledku	Článek v odborném periodiku
Obor	10608 Biochemistry and molecular biology
Stát vydavatele	Švýcarsko
Utajení	není předmětem státního či obchodního tajemství
WWW	URL
Impakt faktor	Impact factor: 4.556
Kód RIV	RIV/00216224:14740/19:00112968
Organizační jednotka	Středoevropský technologický institut
Doi	http://dx.doi.org/10.3390/ijms20215364
UT WoS	000498946100122
Klíčová slova anglicky	breast cancer; abdominal fat; obesity; menopause; hormone dependency; leptin; adiponectin; miRNA; exosomes
Štítky	rivok
Příznaky	Mezinárodní význam, Recenzováno
Změnil	Změnila: Mgr. Pavla Foltynová, Ph.D., učo 106624. Změněno: 12. 5. 2020 13:10.

Anotace
Worldwide, breast cancer (BC) is the most common malignancy in women, in regard to incidence and mortality. In recent years, the negative role of obesity during BC development and progression has been made abundantly clear in several studies. However, the distribution of body fat may be more important to analyze than the overall body weight. In our review of literature, we reported some key findings regarding the role of obesity in BC development, but focused more on central adiposity. Firstly, the adipose microenvironment in obese people bears many similarities with the tumor microenvironment, in respect to associated cellular composition, chronic low-grade inflammation, and high ratio of reactive oxygen species to antioxidants. Secondly, the adipose tissue functions as an endocrine organ, which in obese people produces a high level of tumor-promoting hormones, such as leptin and estrogen, and a low level of the tumor suppressor hormone, adiponectin. As follows, in BC this leads to the activation of oncogenic signaling pathways: NF kappa B, JAK, STAT3, AKT. Moreover, overall obesity, but especially central obesity, promotes a systemic and local low grade chronic inflammation that further stimulates the increase of tumor-promoting oxidative stress. Lastly, there is a constant exchange of information between BC cells and adipocytes, mediated especially by extracellular vesicles, and which changes the transcription profile of both cell types to an oncogenic one with the help of regulatory non-coding RNAs.

Anotace

Worldwide, breast cancer (BC) is the most common malignancy in women, in regard to incidence and mortality. In recent years, the negative role of obesity during BC development and progression has been made abundantly clear in several studies. However, the distribution of body fat may be more important to analyze than the overall body weight. In our review of literature, we reported some key findings regarding the role of obesity in BC development, but focused more on central adiposity. Firstly, the adipose microenvironment in obese people bears many similarities with the tumor microenvironment, in respect to associated cellular composition, chronic low-grade inflammation, and high ratio of reactive oxygen species to antioxidants. Secondly, the adipose tissue functions as an endocrine organ, which in obese people produces a high level of tumor-promoting hormones, such as leptin and estrogen, and a low level of the tumor suppressor hormone, adiponectin. As follows, in BC this leads to the activation of oncogenic signaling pathways: NF kappa B, JAK, STAT3, AKT. Moreover, overall obesity, but especially central obesity, promotes a systemic and local low grade chronic inflammation that further stimulates the increase of tumor-promoting oxidative stress. Lastly, there is a constant exchange of information between BC cells and adipocytes, mediated especially by extracellular vesicles, and which changes the transcription profile of both cell types to an oncogenic one with the help of regulatory non-coding RNAs.