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@article{1623377,
author = {Zimta, A.A. and Tigu, A.B. and Muntean, M. and Cenariu, D. and Slabý, Ondřej and BerindanandNeagoe, I.},
article_location = {Basel},
article_number = {21},
doi = {http://dx.doi.org/10.3390/ijms20215364},
keywords = {breast cancer; abdominal fat; obesity; menopause; hormone dependency; leptin; adiponectin; miRNA; exosomes},
language = {eng},
issn = {1422-0067},
journal = {International Journal of Molecular Sciences},
title = {Molecular Links between Central Obesity and Breast Cancer},
url = {https://www.mdpi.com/1422-0067/20/21/5364/htm},
volume = {20},
year = {2019}
}
TY - JOUR
ID - 1623377
AU - Zimta, A.A. - Tigu, A.B. - Muntean, M. - Cenariu, D. - Slabý, Ondřej - Berindan-Neagoe, I.
PY - 2019
TI - Molecular Links between Central Obesity and Breast Cancer
JF - International Journal of Molecular Sciences
VL - 20
IS - 21
SP - 5364
EP - 5364
PB - Multidisciplinary Digital Publishing Institute
SN - 14220067
KW - breast cancer
KW - abdominal fat
KW - obesity
KW - menopause
KW - hormone dependency
KW - leptin
KW - adiponectin
KW - miRNA
KW - exosomes
UR - https://www.mdpi.com/1422-0067/20/21/5364/htm
L2 - https://www.mdpi.com/1422-0067/20/21/5364/htm
N2 - Worldwide, breast cancer (BC) is the most common malignancy in women, in regard to incidence and mortality. In recent years, the negative role of obesity during BC development and progression has been made abundantly clear in several studies. However, the distribution of body fat may be more important to analyze than the overall body weight. In our review of literature, we reported some key findings regarding the role of obesity in BC development, but focused more on central adiposity. Firstly, the adipose microenvironment in obese people bears many similarities with the tumor microenvironment, in respect to associated cellular composition, chronic low-grade inflammation, and high ratio of reactive oxygen species to antioxidants. Secondly, the adipose tissue functions as an endocrine organ, which in obese people produces a high level of tumor-promoting hormones, such as leptin and estrogen, and a low level of the tumor suppressor hormone, adiponectin. As follows, in BC this leads to the activation of oncogenic signaling pathways: NF kappa B, JAK, STAT3, AKT. Moreover, overall obesity, but especially central obesity, promotes a systemic and local low grade chronic inflammation that further stimulates the increase of tumor-promoting oxidative stress. Lastly, there is a constant exchange of information between BC cells and adipocytes, mediated especially by extracellular vesicles, and which changes the transcription profile of both cell types to an oncogenic one with the help of regulatory non-coding RNAs.
ER -
ZIMTA, A.A., A.B. TIGU, M. MUNTEAN, D. CENARIU, Ondřej SLABÝ and I. BERINDAN-NEAGOE. Molecular Links between Central Obesity and Breast Cancer. \textit{International Journal of Molecular Sciences}. Basel: Multidisciplinary Digital Publishing Institute, 2019, vol.~20, No~21, p.~5364-5384. ISSN~1422-0067. Available from: https://dx.doi.org/10.3390/ijms20215364.
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