A review of microscopy-based evidence for the association of
Propionibacterium acnes biofilms in degenerative disc disease
and other diseased human tissue

J 2019

A review of microscopy-based evidence for the association of Propionibacterium acnes biofilms in degenerative disc disease and other diseased human tissue

CAPOOR, Manu, C. BIRKENMAIER, J.C. WANG, A. MCDOWELL, F.S. AHMED et. al.

Basic information

Original name

A review of microscopy-based evidence for the association of Propionibacterium acnes biofilms in degenerative disc disease and other diseased human tissue

Authors

CAPOOR, Manu (840 United States of America, belonging to the institution), C. BIRKENMAIER (276 Germany), J.C. WANG (840 United States of America), A. MCDOWELL (372 Ireland), F.S. AHMED (50 Bangladesh), H. BRGGEMANN (208 Denmark), E. COSCIA (840 United States of America), D.G. DAVIES (840 United States of America), S. OHRT-NISSEN (208 Denmark), A. RAZ (840 United States of America), Filip RŮŽIČKA (203 Czech Republic, belonging to the institution), J.E. SCHMITZ (840 United States of America), V.A. FISCHETTI (840 United States of America) and Ondřej SLABÝ (203 Czech Republic, guarantor, belonging to the institution)

Edition

European Spine Journal, NEW YORK, Springer, 2019, 0940-6719

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.458

RIV identification code

RIV/00216224:14740/19:00112970

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1007/s00586-019-06086-y

UT WoS

000499770300002

Keywords in English

Acne vulgaris; Arthroscopy; Atherosclerosis; Biofilm; Cutibacterium acnes; Degenerative disc disease; FISH-CLSM; Propionibacterium acnes; Prostate cancer

Abstract

V originále

Purpose Recent research shows an increasing recognition that organisms not traditionally considered infectious in nature contribute to disease processes. Propionibacterium acnes (P. acnes) is a gram-positive, aerotolerant anaerobe prevalent in the sebaceous gland-rich areas of the human skin. A ubiquitous slow-growing organism with the capacity to form biofilm, P. acnes, recognized for its role in acne vulgaris and medical device-related infections, is now also linked to a number of other human diseases. While bacterial culture and molecular techniques are used to investigate the involvement of P. acnes in such diseases, definitive demonstration of P. acnes infection requires a technique (or techniques) sensitive to the presence of biofilms and insensitive to the presence of potential contamination. Fortunately, there are imaging techniques meeting these criteria, in particular, fluorescence in situ hybridization and immunofluorescence coupled with confocal laser scanning microscopy, as well as immunohistochemistry. Methods Our literature review considers a range of microscopy-based studies that provides definitive evidence of P. acnes colonization within tissue from a number of human diseases (acne vulgaris, degenerative disc and prostate disease and atherosclerosis), some of which are currently not considered to have an infectious etiology. Results/Conclusion We conclude that P. acnes is an opportunistic pathogen with a likely underestimated role in the development of various human diseases associated with significant morbidity and, in some cases, mortality. As such, these findings offer the potential for new studies aimed at understanding the pathological mechanisms driving the observed disease associations, as well as novel diagnostic strategies and treatment strategies, particularly for degenerative disc disease. Graphic abstract These slides can be retrieved under Electronic Supplementary Material.

Links

MUNI/A/1189/2018, interní kód MU

Name: Původci nozokomiálních nákaz a možnosti jejich diagnostiky a terapie (Acronym: PNNMDT)

Investor: Masaryk University, Category A

Citovat

CAPOOR, Manu, C. BIRKENMAIER, J.C. WANG, A. MCDOWELL, F.S. AHMED, H. BRGGEMANN, E. COSCIA, D.G. DAVIES, S. OHRT-NISSEN, A. RAZ, Filip RŮŽIČKA, J.E. SCHMITZ, V.A. FISCHETTI and Ondřej SLABÝ. A review of microscopy-based evidence for the association of Propionibacterium acnes biofilms in degenerative disc disease and other diseased human tissue. European Spine Journal. NEW YORK: Springer, 2019, vol. 28, No 12, p. 2951-2971. ISSN 0940-6719. Available from: https://dx.doi.org/10.1007/s00586-019-06086-y.

@article{1623459,
   author = {Capoor, Manu and Birkenmaier, C. and Wang, J.C. and McDowell, A. and Ahmed, F.S. and Brggemann, H. and Coscia, E. and Davies, D.G. and OhrtandNissen, S. and Raz, A. and Růžička, Filip and Schmitz, J.E. and Fischetti, V.A. and Slabý, Ondřej},
   article_location = {NEW YORK},
   article_number = {12},
   doi = {http://dx.doi.org/10.1007/s00586-019-06086-y},
   keywords = {Acne vulgaris; Arthroscopy; Atherosclerosis; Biofilm; Cutibacterium acnes; Degenerative disc disease; FISH-CLSM; Propionibacterium acnes; Prostate cancer},
   language = {eng},
   issn = {0940-6719},
   journal = {European Spine Journal},
   title = {A review of microscopy-based evidence for the association of Propionibacterium acnes biofilms in degenerative disc disease and other diseased human tissue},
   url = {https://link.springer.com/article/10.1007%2Fs00586-019-06086-y#Ack1},
   volume = {28},
   year = {2019}
}

TY  - JOUR
ID  - 1623459
AU  - Capoor, Manu - Birkenmaier, C. - Wang, J.C. - McDowell, A. - Ahmed, F.S. - Brggemann, H. - Coscia, E. - Davies, D.G. - Ohrt-Nissen, S. - Raz, A. - Růžička, Filip - Schmitz, J.E. - Fischetti, V.A. - Slabý, Ondřej
PY  - 2019
TI  - A review of microscopy-based evidence for the association of Propionibacterium acnes biofilms in degenerative disc disease and other diseased human tissue
JF  - European Spine Journal
VL  - 28
IS  - 12
SP  - 2951-2971
EP  - 2951-2971
PB  - Springer
SN  - 09406719
KW  - Acne vulgaris
KW  - Arthroscopy
KW  - Atherosclerosis
KW  - Biofilm
KW  - Cutibacterium acnes
KW  - Degenerative disc disease
KW  - FISH-CLSM
KW  - Propionibacterium acnes
KW  - Prostate cancer
UR  - https://link.springer.com/article/10.1007%2Fs00586-019-06086-y#Ack1
L2  - https://link.springer.com/article/10.1007%2Fs00586-019-06086-y#Ack1
N2  - Purpose Recent research shows an increasing recognition that organisms not traditionally considered infectious in nature contribute to disease processes. Propionibacterium acnes (P. acnes) is a gram-positive, aerotolerant anaerobe prevalent in the sebaceous gland-rich areas of the human skin. A ubiquitous slow-growing organism with the capacity to form biofilm, P. acnes, recognized for its role in acne vulgaris and medical device-related infections, is now also linked to a number of other human diseases. While bacterial culture and molecular techniques are used to investigate the involvement of P. acnes in such diseases, definitive demonstration of P. acnes infection requires a technique (or techniques) sensitive to the presence of biofilms and insensitive to the presence of potential contamination. Fortunately, there are imaging techniques meeting these criteria, in particular, fluorescence in situ hybridization and immunofluorescence coupled with confocal laser scanning microscopy, as well as immunohistochemistry. Methods Our literature review considers a range of microscopy-based studies that provides definitive evidence of P. acnes colonization within tissue from a number of human diseases (acne vulgaris, degenerative disc and prostate disease and atherosclerosis), some of which are currently not considered to have an infectious etiology. Results/Conclusion We conclude that P. acnes is an opportunistic pathogen with a likely underestimated role in the development of various human diseases associated with significant morbidity and, in some cases, mortality. As such, these findings offer the potential for new studies aimed at understanding the pathological mechanisms driving the observed disease associations, as well as novel diagnostic strategies and treatment strategies, particularly for degenerative disc disease. Graphic abstract These slides can be retrieved under Electronic Supplementary Material.
ER  -

CAPOOR, Manu, C. BIRKENMAIER, J.C. WANG, A. MCDOWELL, F.S. AHMED, H. BRGGEMANN, E. COSCIA, D.G. DAVIES, S. OHRT-NISSEN, A. RAZ, Filip RŮŽIČKA, J.E. SCHMITZ, V.A. FISCHETTI and Ondřej SLABÝ. A review of microscopy-based evidence for the association of Propionibacterium acnes biofilms in degenerative disc disease and other diseased human tissue. \textit{European Spine Journal}. NEW YORK: Springer, 2019, vol.~28, No~12, p.~2951-2971. ISSN~0940-6719. Available from: https://dx.doi.org/10.1007/s00586-019-06086-y.

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