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@article{1623466,
author = {Vychytilová, Petra and Slabý, Ondřej},
article_location = {Amsterdam},
article_number = {DEC},
doi = {http://dx.doi.org/10.1016/j.mam.2019.03.002},
keywords = {miR-215; Proliferation; Cell cycle; Apoptosis; Biomarker; Therapeutic target},
language = {eng},
issn = {0098-2997},
journal = {Molecular aspects of medicine},
title = {MicroRNA-215: From biology to theranostic applications},
url = {https://www.sciencedirect.com/science/article/pii/S0098299719300019?via%3Dihub},
volume = {70},
year = {2019}
}
TY - JOUR
ID - 1623466
AU - Vychytilová, Petra - Slabý, Ondřej
PY - 2019
TI - MicroRNA-215: From biology to theranostic applications
JF - Molecular aspects of medicine
VL - 70
IS - DEC
SP - 72-89
EP - 72-89
PB - Elsevier
SN - 00982997
KW - miR-215
KW - Proliferation
KW - Cell cycle
KW - Apoptosis
KW - Biomarker
KW - Therapeutic target
UR - https://www.sciencedirect.com/science/article/pii/S0098299719300019?via%3Dihub
L2 - https://www.sciencedirect.com/science/article/pii/S0098299719300019?via%3Dihub
N2 - MicroRNA-215 (miR-215) is one of the extensively studied microRNAs (miRNAs) in human diseases, especially in different types of cancer, where it plays various roles in the initiation and progression of tumors. There is also a high conservation of miR-215 among wide range of different species indicating that this miRNA may have vital functions that are maintained during evolution. During the last ten years, significant efforts were dedicated to uncover molecular mechanisms of miR-215 regulation and cellular functioning. In addition, miR-215 was repeatedly identified to have the causal roles in pathology of various diseases, where it may serve as a promising diagnostic, prognostic or predictive biomarker and as a therapeutic target. Here, we overview more than 150 reports focused on miR-215 to allow the synthesis of knowledge on its transcriptional and post-transcriptional regulation, and functioning in essential biological processes like cell and tissue development, cell survival, cell cycle and proliferation, cell migration and invasion, cellular microenvironment communication, and metabolism. Further, we summarized the findings on miR-215 roles in pathology of nonmalignant diseases and various types of cancer with special focus on miR-215 as a promising molecule for future development of theranostic miRNA-based approaches. Although it is difficult to evaluate the full theranostic potential of miR-215, it is probable that during the following years, an increasing number of theranostic miRNA modalities that overcome the current technological obstacles will appear, and enable the translation of miR-215 knowledge into the clinic.
ER -
VYCHYTILOVÁ, Petra and Ondřej SLABÝ. MicroRNA-215: From biology to theranostic applications. \textit{Molecular aspects of medicine}. Amsterdam: Elsevier, 2019, vol.~70, DEC, p.~72-89. ISSN~0098-2997. Available from: https://dx.doi.org/10.1016/j.mam.2019.03.002.
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