Behavioral and Neuroanatomical Account of Impulsivity in
Parkinson's Disease

J 2020

Behavioral and Neuroanatomical Account of Impulsivity in Parkinson's Disease

HLAVATÁ, Pavlína, Pavla LINHARTOVÁ, Rastislav ŠUMEC, Pavel FILIP, Miroslav SVĚTLÁK et. al.

Basic information

Original name

Behavioral and Neuroanatomical Account of Impulsivity in Parkinson's Disease

Authors

HLAVATÁ, Pavlína (203 Czech Republic, belonging to the institution), Pavla LINHARTOVÁ (203 Czech Republic, belonging to the institution), Rastislav ŠUMEC (703 Slovakia, belonging to the institution), Pavel FILIP (703 Slovakia, guarantor, belonging to the institution), Miroslav SVĚTLÁK (203 Czech Republic, belonging to the institution), Marek BALÁŽ (703 Slovakia, belonging to the institution), Tomáš KAŠPÁREK (203 Czech Republic, belonging to the institution) and Martin BAREŠ (203 Czech Republic, belonging to the institution)

Edition

FRONTIERS IN NEUROLOGY, LAUSANNE, FRONTIERS MEDIA SA, 2020, 1664-2295

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.003

RIV identification code

RIV/00216224:14110/20:00115338

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3389/fneur.2019.01338

UT WoS

000509278800001

Keywords in English

impulse control disorder; Parkinson's disease; impulsive action; impulsive choice; structural MRI; Iowa gambling task; delay discounting task; stop signal task

Abstract

V originále

Impulse control disorder (ICD) is a major non-motor complication of Parkinson's disease (PD) with often devastating consequences for patients' quality of life. In this study, we aimed to characterize the phenotype of impulsivity in PD and its neuroanatomical correlates. Methods: Thirty-seven PD patients (15 patients with ICD, 22 patients without ICD) and 36 healthy controls underwent a neuropsychological battery. The test battery consisted of anxiety and depression scales, self-report measures of impulsivity (Barratt scale and UPPS-P), behavioral measures of impulsive action (Go/No-Go task, Stop signal task) and impulsive choice (Delay discounting, Iowa gambling task), and measures of cognitive abilities (working memory, attention, executive function). Patients and controls underwent structural MRI scanning. Results: Patients with ICD had significantly higher levels of self-reported impulsivity (Barratt scale and Lack of perseverance from UPPS-P) in comparison with healthy controls and non-impulsive PD patients, but they performed similarly in behavioral tasks, except for the Iowa gambling task. In this task, patients with ICD made significantly less risky decisions than patients without ICD and healthy controls. Patients without ICD did not differ from healthy controls in self-reported impulsivity or behavioral measurements. Both patient groups were more anxious and depressive than healthy controls. MRI scanning revealed structural differences in cortical areas related to impulse control in both patient groups. Patients without ICD had lower volumes and cortical thickness of bilateral inferior frontal gyrus. Patients with ICD had higher volumes of right caudal anterior cingulate and rostral middle frontal cortex. Conclusions: Despite the presence of ICD as confirmed by both clinical follow-up and self-reported impulsivity scales and supported by structural differences in various neural nodes related to inhibitory control and reward processing, patients with ICD performed no worse than healthy controls in various behavioral tasks previously hypothesized as robust impulsivity measures. These results call for caution against impetuous interpretation of behavioral tests, since various factors may and will influence the ultimate outcomes, be it the lack of sensitivity in specific, limited ICD subtypes, excessive caution of ICD patients during testing due to previous negative experience rendering simplistic tasks insufficient, or other, as of now unknown aspects, calling for further research.

Links

NV15-30062A, research and development project

Name: Fenotypy impulzivity u neuropsychiatrických poruch a jejich klinický význam

691110, interní kód MU

Name: Advanced MR methods for characterization of microstructural brain damage (MICROBRADAM) (Acronym: MICROBRADAM)

Investor: European Union, MSCA Marie Skłodowska-Curie Actions (Excellent Science)

90062, large research infrastructures

Name: Czech-BioImaging

Citovat

HLAVATÁ, Pavlína, Pavla LINHARTOVÁ, Rastislav ŠUMEC, Pavel FILIP, Miroslav SVĚTLÁK, Marek BALÁŽ, Tomáš KAŠPÁREK and Martin BAREŠ. Behavioral and Neuroanatomical Account of Impulsivity in Parkinson's Disease. FRONTIERS IN NEUROLOGY. LAUSANNE: FRONTIERS MEDIA SA, 2020, vol. 10, JAN 10 2020, p. 1-12. ISSN 1664-2295. Available from: https://dx.doi.org/10.3389/fneur.2019.01338.

@article{1623836,
   author = {Hlavatá, Pavlína and Linhartová, Pavla and Šumec, Rastislav and Filip, Pavel and Světlák, Miroslav and Baláž, Marek and Kašpárek, Tomáš and Bareš, Martin},
   article_location = {LAUSANNE},
   article_number = {JAN 10 2020},
   doi = {http://dx.doi.org/10.3389/fneur.2019.01338},
   keywords = {impulse control disorder; Parkinson's disease; impulsive action; impulsive choice; structural MRI; Iowa gambling task; delay discounting task; stop signal task},
   language = {eng},
   issn = {1664-2295},
   journal = {FRONTIERS IN NEUROLOGY},
   title = {Behavioral and Neuroanatomical Account of Impulsivity in Parkinson's Disease},
   url = {http://dx.doi.org/10.3389/fneur.2019.01338},
   volume = {10},
   year = {2020}
}

TY  - JOUR
ID  - 1623836
AU  - Hlavatá, Pavlína - Linhartová, Pavla - Šumec, Rastislav - Filip, Pavel - Světlák, Miroslav - Baláž, Marek - Kašpárek, Tomáš - Bareš, Martin
PY  - 2020
TI  - Behavioral and Neuroanatomical Account of Impulsivity in Parkinson's Disease
JF  - FRONTIERS IN NEUROLOGY
VL  - 10
IS  - JAN 10 2020
SP  - 1-12
EP  - 1-12
PB  - FRONTIERS MEDIA SA
SN  - 16642295
KW  - impulse control disorder
KW  - Parkinson's disease
KW  - impulsive action
KW  - impulsive choice
KW  - structural MRI
KW  - Iowa gambling task
KW  - delay discounting task
KW  - stop signal task
UR  - http://dx.doi.org/10.3389/fneur.2019.01338
L2  - http://dx.doi.org/10.3389/fneur.2019.01338
N2  - Impulse control disorder (ICD) is a major non-motor complication of Parkinson's disease (PD) with often devastating consequences for patients' quality of life. In this study, we aimed to characterize the phenotype of impulsivity in PD and its neuroanatomical correlates. Methods: Thirty-seven PD patients (15 patients with ICD, 22 patients without ICD) and 36 healthy controls underwent a neuropsychological battery. The test battery consisted of anxiety and depression scales, self-report measures of impulsivity (Barratt scale and UPPS-P), behavioral measures of impulsive action (Go/No-Go task, Stop signal task) and impulsive choice (Delay discounting, Iowa gambling task), and measures of cognitive abilities (working memory, attention, executive function). Patients and controls underwent structural MRI scanning. Results: Patients with ICD had significantly higher levels of self-reported impulsivity (Barratt scale and Lack of perseverance from UPPS-P) in comparison with healthy controls and non-impulsive PD patients, but they performed similarly in behavioral tasks, except for the Iowa gambling task. In this task, patients with ICD made significantly less risky decisions than patients without ICD and healthy controls. Patients without ICD did not differ from healthy controls in self-reported impulsivity or behavioral measurements. Both patient groups were more anxious and depressive than healthy controls. MRI scanning revealed structural differences in cortical areas related to impulse control in both patient groups. Patients without ICD had lower volumes and cortical thickness of bilateral inferior frontal gyrus. Patients with ICD had higher volumes of right caudal anterior cingulate and rostral middle frontal cortex. Conclusions: Despite the presence of ICD as confirmed by both clinical follow-up and self-reported impulsivity scales and supported by structural differences in various neural nodes related to inhibitory control and reward processing, patients with ICD performed no worse than healthy controls in various behavioral tasks previously hypothesized as robust impulsivity measures. These results call for caution against impetuous interpretation of behavioral tests, since various factors may and will influence the ultimate outcomes, be it the lack of sensitivity in specific, limited ICD subtypes, excessive caution of ICD patients during testing due to previous negative experience rendering simplistic tasks insufficient, or other, as of now unknown aspects, calling for further research.
ER  -

HLAVATÁ, Pavlína, Pavla LINHARTOVÁ, Rastislav ŠUMEC, Pavel FILIP, Miroslav SVĚTLÁK, Marek BALÁŽ, Tomáš KAŠPÁREK and Martin BAREŠ. Behavioral and Neuroanatomical Account of Impulsivity in Parkinson's Disease. \textit{FRONTIERS IN NEUROLOGY}. LAUSANNE: FRONTIERS MEDIA SA, 2020, vol.~10, JAN 10 2020, p.~1-12. ISSN~1664-2295. Available from: https://dx.doi.org/10.3389/fneur.2019.01338.

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