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@article{1623996,
author = {Veselská, Renata and Ježová, Marta and Kýr, Michal and Mazánek, Pavel and Chlapek, Petr and Dobrotková, Viera and Štěrba, Jaroslav},
article_location = {Lausanne},
article_number = {NOV 15},
doi = {http://dx.doi.org/10.3389/fonc.2019.01221},
keywords = {HOXC9; NF1; PBX1; immunohistochemistry; neuroblastoma; predictive markers; prognostic markers},
language = {eng},
issn = {2234-943X},
journal = {Frontiers in Oncology},
title = {Comparative Analysis of Putative Prognostic and Predictive Markers in Neuroblastomas: High Expression of PBX1 Is Associated With a Poor Response to Induction Therapy},
url = {https://www.frontiersin.org/articles/10.3389/fonc.2019.01221/full},
volume = {9},
year = {2019}
}
TY - JOUR
ID - 1623996
AU - Veselská, Renata - Ježová, Marta - Kýr, Michal - Mazánek, Pavel - Chlapek, Petr - Dobrotková, Viera - Štěrba, Jaroslav
PY - 2019
TI - Comparative Analysis of Putative Prognostic and Predictive Markers in Neuroblastomas: High Expression of PBX1 Is Associated With a Poor Response to Induction Therapy
JF - Frontiers in Oncology
VL - 9
IS - NOV 15
SP - 1-12
EP - 1-12
PB - Frontiers Media SA
SN - 2234943X
KW - HOXC9
KW - NF1
KW - PBX1
KW - immunohistochemistry
KW - neuroblastoma
KW - predictive markers
KW - prognostic markers
UR - https://www.frontiersin.org/articles/10.3389/fonc.2019.01221/full
L2 - https://www.frontiersin.org/articles/10.3389/fonc.2019.01221/full
N2 - The survival rate for patients with high-risk neuroblastomas remains poor despite new improvements in available therapeutic modalities. A detailed understanding of the mechanisms underlying clinical responses to multimodal treatment is one of the important aspects that may provide precision in the prediction of a patient's clinical outcome. Our study was designed as a detailed comparative analysis of five selected proteins (DDX39A, HMGA1, HOXC9, NF1, and PBX1) in one cohort of patients using the same methodical approaches. These proteins were already reported separately as related to the resistance or sensitivity to retinoids and as useful prognostic markers of survival probability. In the cohort of 19 patients suffering from high-risk neuroblastomas, we analyzed initial immunohistochemistry samples obtained by diagnostic biopsy and post-induction samples taken after the end of induction therapy. The expression of DDX39A, HMGA1, HOXC9, and NF1 showed varied patterns with almost no differences between responders and non-responders. Nevertheless, we found very interesting results for PBX1: non-responders had significantly higher expression levels of this protein in the initial tumor samples when compared with responders; this expression pattern changed inversely in the post-induction samples, and this change was also statistically significant. Moreover, our results from survival analyses reveal the prognostic value of PBX1, NF1, and HOXC9 expression in neuroblastoma tissue. In addition to the prognostic importance of PBX1, NF1, and HOXC9 proteins, our results demonstrated that PBX1 could be used for the prediction of the clinical response to induction chemotherapy in patients suffering from high-risk neuroblastoma.
ER -
VESELSKÁ, Renata, Marta JEŽOVÁ, Michal KÝR, Pavel MAZÁNEK, Petr CHLAPEK, Viera DOBROTKOVÁ a Jaroslav ŠTĚRBA. Comparative Analysis of Putative Prognostic and Predictive Markers in Neuroblastomas: High Expression of PBX1 Is Associated With a Poor Response to Induction Therapy. Online. \textit{Frontiers in Oncology}. Lausanne: Frontiers Media SA, 2019, roč.~9, NOV 15, s.~1-12. ISSN~2234-943X. Dostupné z: https://dx.doi.org/10.3389/fonc.2019.01221. [citováno 2024-04-23]
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