Effect of impaired cardiac conduction after alcohol septal ablation on clinical outcomes: insights from the Euro-ASA registry

JENSEN, Morten Kvistholm, Lothar FABER, Max LIEBREGTS, Jaroslav JANUSKA, Jan KREJČÍ, Thomas BARTEL, Robert M. COOPER, Maciej DABROWSKI, Peter Riis HANSEN, Vibeke Marie ALMAAS, Hubert SEGGEWISS, Dieter HORSTKOTTE, Radka ADLOVA, Jurrien TEN BERG, Henning BUNDGAARD and Josef VESELKA. Effect of impaired cardiac conduction after alcohol septal ablation on clinical outcomes: insights from the Euro-ASA registry. EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES. OXFORD: OXFORD UNIV PRESS, 2019, vol. 5, No 3, p. 252-258. ISSN 2058-5225. Available from: https://dx.doi.org/10.1093/ehjqcco/qcy049.

Basic information

Original name

Effect of impaired cardiac conduction after alcohol septal ablation on clinical outcomes: insights from the Euro-ASA registry

Authors

JENSEN, Morten Kvistholm (208 Denmark, guarantor), Lothar FABER (276 Germany), Max LIEBREGTS (528 Netherlands), Jaroslav JANUSKA (203 Czech Republic), Jan KREJČÍ (203 Czech Republic, belonging to the institution), Thomas BARTEL (40 Austria), Robert M. COOPER (826 United Kingdom of Great Britain and Northern Ireland), Maciej DABROWSKI (616 Poland), Peter Riis HANSEN (208 Denmark), Vibeke Marie ALMAAS (578 Norway), Hubert SEGGEWISS (276 Germany), Dieter HORSTKOTTE (276 Germany), Radka ADLOVA (203 Czech Republic), Jurrien TEN BERG (528 Netherlands), Henning BUNDGAARD (276 Germany) and Josef VESELKA (203 Czech Republic)

Edition

EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES, OXFORD, OXFORD UNIV PRESS, 2019, 2058-5225

---

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

Slovenia

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

RIV identification code

RIV/00216224:14110/19:00112991

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1093/ehjqcco/qcy049

UT WoS

000493732200013

Keywords in English

Hypertrophic cardiomyopathy; Alcohol septal ablation; Pacemaker; Implantable cardioverter-defibrillator; Bundle branch block; Cardiac conduction; Survival

Tags

14110115, rivok

Tags

International impact, Reviewed

---

Abstract

V originále

Aims We analysed the impact of bundle branch block (BBB) and pacemaker (PM) implantation on symptoms and survival after alcohol septal ablation (ASA) in patients with hypertrophic cardiomyopathy (HCM). Methods and results Among 1416 HCM patients from the Euro-ASA registry, 58 (4%) patients had a PM and 64 (5%) patients had an implantable cardioverter-defibrillator (ICD) before ASA. At latest follow-up (5.0 +/- 4.0 years) after ASA, 118 (8%) patients had an ICD and 229 (16%) patients had a PM. In patients without an implantable device prior to ASA 13% had a PM and 5% had an ICD implanted following ASA. New onset BBB was present in 44% (right BBB in 31%) of patients without previous BBB. At latest follow-up, we found no associations between BBB and New York Heart Association (NYHA) Class 3-4 [odds ratio (OR) 0.98, 95% confidence interval (CI) 0.63-1.51; P = 0.91] or Canadian Cardiovascular Society (CCS) Class 3-4 (OR 1.5, CI 0.32-6.7; P = 0.62), respectively, and no associations between PM and NYHA Class 3-4 (OR 1.2, CI 0.70-2.0; P = 0.52) or CCS 3-4 (OR 1.3, CI 0.24-6.6; P = 0.79), respectively. The survival after ASA was not reduced in patients with BBB [hazard ratio (HR) 0.73, CI 0.53-1.01; P = 0.06] or PM (HR 0.78, CI 0.52-1.17; P = 0.24). Conclusions Development of BBB or need for a PM after ASA in patients with obstructive HCM was not associated with inferior symptomatic outcome or reduced survival, thus concerns for the negative impact of impaired cardiac conduction on the clinical outcome after ASA were not confirmed.