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@article{1624037,
author = {Jensen, Morten Kvistholm and Faber, Lothar and Liebregts, Max and Januska, Jaroslav and Krejčí, Jan and Bartel, Thomas and Cooper, Robert M. and Dabrowski, Maciej and Hansen, Peter Riis and Almaas, Vibeke Marie and Seggewiss, Hubert and Horstkotte, Dieter and Adlova, Radka and ten Berg, Jurrien and Bundgaard, Henning and Veselka, Josef},
article_location = {OXFORD},
article_number = {3},
doi = {http://dx.doi.org/10.1093/ehjqcco/qcy049},
keywords = {Hypertrophic cardiomyopathy; Alcohol septal ablation; Pacemaker; Implantable cardioverter-defibrillator; Bundle branch block; Cardiac conduction; Survival},
language = {eng},
issn = {2058-5225},
journal = {EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES},
title = {Effect of impaired cardiac conduction after alcohol septal ablation on clinical outcomes: insights from the Euro-ASA registry},
url = {http://dx.doi.org/10.1093/ehjqcco/qcy049},
volume = {5},
year = {2019}
}
TY - JOUR
ID - 1624037
AU - Jensen, Morten Kvistholm - Faber, Lothar - Liebregts, Max - Januska, Jaroslav - Krejčí, Jan - Bartel, Thomas - Cooper, Robert M. - Dabrowski, Maciej - Hansen, Peter Riis - Almaas, Vibeke Marie - Seggewiss, Hubert - Horstkotte, Dieter - Adlova, Radka - ten Berg, Jurrien - Bundgaard, Henning - Veselka, Josef
PY - 2019
TI - Effect of impaired cardiac conduction after alcohol septal ablation on clinical outcomes: insights from the Euro-ASA registry
JF - EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
VL - 5
IS - 3
SP - 252-258
EP - 252-258
PB - OXFORD UNIV PRESS
SN - 20585225
KW - Hypertrophic cardiomyopathy
KW - Alcohol septal ablation
KW - Pacemaker
KW - Implantable cardioverter-defibrillator
KW - Bundle branch block
KW - Cardiac conduction
KW - Survival
UR - http://dx.doi.org/10.1093/ehjqcco/qcy049
L2 - http://dx.doi.org/10.1093/ehjqcco/qcy049
N2 - Aims We analysed the impact of bundle branch block (BBB) and pacemaker (PM) implantation on symptoms and survival after alcohol septal ablation (ASA) in patients with hypertrophic cardiomyopathy (HCM). Methods and results Among 1416 HCM patients from the Euro-ASA registry, 58 (4%) patients had a PM and 64 (5%) patients had an implantable cardioverter-defibrillator (ICD) before ASA. At latest follow-up (5.0 +/- 4.0 years) after ASA, 118 (8%) patients had an ICD and 229 (16%) patients had a PM. In patients without an implantable device prior to ASA 13% had a PM and 5% had an ICD implanted following ASA. New onset BBB was present in 44% (right BBB in 31%) of patients without previous BBB. At latest follow-up, we found no associations between BBB and New York Heart Association (NYHA) Class 3-4 [odds ratio (OR) 0.98, 95% confidence interval (CI) 0.63-1.51; P = 0.91] or Canadian Cardiovascular Society (CCS) Class 3-4 (OR 1.5, CI 0.32-6.7; P = 0.62), respectively, and no associations between PM and NYHA Class 3-4 (OR 1.2, CI 0.70-2.0; P = 0.52) or CCS 3-4 (OR 1.3, CI 0.24-6.6; P = 0.79), respectively. The survival after ASA was not reduced in patients with BBB [hazard ratio (HR) 0.73, CI 0.53-1.01; P = 0.06] or PM (HR 0.78, CI 0.52-1.17; P = 0.24). Conclusions Development of BBB or need for a PM after ASA in patients with obstructive HCM was not associated with inferior symptomatic outcome or reduced survival, thus concerns for the negative impact of impaired cardiac conduction on the clinical outcome after ASA were not confirmed.
ER -
JENSEN, Morten Kvistholm, Lothar FABER, Max LIEBREGTS, Jaroslav JANUSKA, Jan KREJČÍ, Thomas BARTEL, Robert M. COOPER, Maciej DABROWSKI, Peter Riis HANSEN, Vibeke Marie ALMAAS, Hubert SEGGEWISS, Dieter HORSTKOTTE, Radka ADLOVA, Jurrien TEN BERG, Henning BUNDGAARD and Josef VESELKA. Effect of impaired cardiac conduction after alcohol septal ablation on clinical outcomes: insights from the Euro-ASA registry. \textit{EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES}. OXFORD: OXFORD UNIV PRESS, 2019, vol.~5, No~3, p.~252-258. ISSN~2058-5225. Available from: https://dx.doi.org/10.1093/ehjqcco/qcy049.
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