HUMAN WHARTON'S JELLY MESENCHYMAL STEM CELLS: PROPERTIES,
ISOLATION AND CLINICAL APPLICATIONS

J 2019

HUMAN WHARTON'S JELLY MESENCHYMAL STEM CELLS: PROPERTIES, ISOLATION AND CLINICAL APPLICATIONS

BORYS-WOJCIK, S., S. BRAZERT, M. JANKOWSKI, M. OZEGOWSKA, K. CHERMULA et. al.

Basic information

Original name

HUMAN WHARTON'S JELLY MESENCHYMAL STEM CELLS: PROPERTIES, ISOLATION AND CLINICAL APPLICATIONS

Authors

BORYS-WOJCIK, S. (616 Poland), S. BRAZERT (616 Poland), M. JANKOWSKI (616 Poland), M. OZEGOWSKA (616 Poland), K. CHERMULA (616 Poland), B. PIOTROWSKA-KEMPISTY (616 Poland), H. BUKOWSKA (616 Poland), D. ANTOSIK (616 Poland), P. PAWELCZYK (616 Poland), L. NOWICKI (616 Poland), Michal JEŠETA (203 Czech Republic, belonging to the institution) and M. KEMPISTY (616 Poland, guarantor)

Edition

Journal of biological regulators and homeostatic agents, Silva Marina, Biolife SAS, 2019, 0393-974X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10601 Cell biology

Country of publisher

Italy

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 1.506

RIV identification code

RIV/00216224:14110/19:00113003

Organization unit

Faculty of Medicine

UT WoS

000464697500015

Keywords in English

mesenchymal stem cells; WJ; properties; isolation; clinical application

Abstract

V originále

Human Wharton's jelly mesenchymal stem cells (WJ-MSCs) exhibit CD29, CD79 and CD105 markers, characteristic for mesenchymal cell lines. Under the influence of the appropriate factors, WJ-MSCs can be dedifferentiated to osteoblasts, chondrocytes, adipocytes, myocytes, cardiomyocytes, glial cells and dopaminergic neurons. Wharton's jelly (WJ) is one of the potential sources of mesenchymal stem cells (MSCs) - obtaining these cells does not raise moral or ethical objections, because the umbilical cord (UC) is a regular waste material. The expression of the OCT-4 and Nanog proteins, which are characteristic for WJ-MSCs may indicate that these cells have retained some embryonic character. The collected data suggests that WJMSCs show increased division and telomerase activity compared to bone marrow MSCs (BM-MSCs). The published results showed no human leucocyte antigen (HLA) class II expression, with the possibility of HLA class I modification by WJ-MSCs, allowing for the transplantation of these cells both within the same and other species - which allows the use of human cells in animal models. The results of selected studies indicate that WJ-MSCs can be an essential element of regenerative medicine of the 21st century.

Citovat

BORYS-WOJCIK, S., S. BRAZERT, M. JANKOWSKI, M. OZEGOWSKA, K. CHERMULA, B. PIOTROWSKA-KEMPISTY, H. BUKOWSKA, D. ANTOSIK, P. PAWELCZYK, L. NOWICKI, Michal JEŠETA and M. KEMPISTY. HUMAN WHARTON'S JELLY MESENCHYMAL STEM CELLS: PROPERTIES, ISOLATION AND CLINICAL APPLICATIONS. Journal of biological regulators and homeostatic agents. Silva Marina: Biolife SAS, 2019, vol. 33, No 1, p. 119-123. ISSN 0393-974X.

@article{1624676,
   author = {BorysandWojcik, S. and Brazert, S. and Jankowski, M. and Ozegowska, M. and Chermula, K. and PiotrowskaandKempisty, B. and Bukowska, H. and Antosik, D. and Pawelczyk, P. and Nowicki, L. and Ješeta, Michal and Kempisty, M.},
   article_location = {Silva Marina},
   article_number = {1},
   keywords = {mesenchymal stem cells; WJ; properties; isolation; clinical application},
   language = {eng},
   issn = {0393-974X},
   journal = {Journal of biological regulators and homeostatic agents},
   title = {HUMAN WHARTON'S JELLY MESENCHYMAL STEM CELLS: PROPERTIES, ISOLATION AND CLINICAL APPLICATIONS},
   url = {https://www.ncbi.nlm.nih.gov/pubmed/30729769},
   volume = {33},
   year = {2019}
}

TY  - JOUR
ID  - 1624676
AU  - Borys-Wojcik, S. - Brazert, S. - Jankowski, M. - Ozegowska, M. - Chermula, K. - Piotrowska-Kempisty, B. - Bukowska, H. - Antosik, D. - Pawelczyk, P. - Nowicki, L. - Ješeta, Michal - Kempisty, M.
PY  - 2019
TI  - HUMAN WHARTON'S JELLY MESENCHYMAL STEM CELLS: PROPERTIES, ISOLATION AND CLINICAL APPLICATIONS
JF  - Journal of biological regulators and homeostatic agents
VL  - 33
IS  - 1
SP  - 119-123
EP  - 119-123
PB  - Biolife SAS
SN  - 0393974X
KW  - mesenchymal stem cells
KW  - WJ
KW  - properties
KW  - isolation
KW  - clinical application
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30729769
L2  - https://www.ncbi.nlm.nih.gov/pubmed/30729769
N2  - Human Wharton's jelly mesenchymal stem cells (WJ-MSCs) exhibit CD29, CD79 and CD105 markers, characteristic for mesenchymal cell lines. Under the influence of the appropriate factors, WJ-MSCs can be dedifferentiated to osteoblasts, chondrocytes, adipocytes, myocytes, cardiomyocytes, glial cells and dopaminergic neurons. Wharton's jelly (WJ) is one of the potential sources of mesenchymal stem cells (MSCs) - obtaining these cells does not raise moral or ethical objections, because the umbilical cord (UC) is a regular waste material. The expression of the OCT-4 and Nanog proteins, which are characteristic for WJ-MSCs may indicate that these cells have retained some embryonic character. The collected data suggests that WJMSCs show increased division and telomerase activity compared to bone marrow MSCs (BM-MSCs). The published results showed no human leucocyte antigen (HLA) class II expression, with the possibility of HLA class I modification by WJ-MSCs, allowing for the transplantation of these cells both within the same and other species - which allows the use of human cells in animal models. The results of selected studies indicate that WJ-MSCs can be an essential element of regenerative medicine of the 21st century.
ER  -

BORYS-WOJCIK, S., S. BRAZERT, M. JANKOWSKI, M. OZEGOWSKA, K. CHERMULA, B. PIOTROWSKA-KEMPISTY, H. BUKOWSKA, D. ANTOSIK, P. PAWELCZYK, L. NOWICKI, Michal JEŠETA and M. KEMPISTY. HUMAN WHARTON'S JELLY MESENCHYMAL STEM CELLS: PROPERTIES, ISOLATION AND CLINICAL APPLICATIONS. \textit{Journal of biological regulators and homeostatic agents}. Silva Marina: Biolife SAS, 2019, vol.~33, No~1, p.~119-123. ISSN~0393-974X.

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