Detailed Information on Publication Record
2019
INSIGHT INTO "NUCLEAR-CYTOPLASMIC SHUTTLING" AS A DEVELOPMENTAL AND DIFFERENTIATIONAL CAPABILITY OF CELLS IN PRIMARY CULTURE MODELS
KULUS, M., M. BRAZERT, M. POPIS, B. BOROWIEC, D. BUKOWSKA et. al.Basic information
Original name
INSIGHT INTO "NUCLEAR-CYTOPLASMIC SHUTTLING" AS A DEVELOPMENTAL AND DIFFERENTIATIONAL CAPABILITY OF CELLS IN PRIMARY CULTURE MODELS
Authors
KULUS, M. (616 Poland), M. BRAZERT (616 Poland), M. POPIS (616 Poland), B. BOROWIEC (616 Poland), D. BUKOWSKA (616 Poland), Michal JEŠETA (203 Czech Republic, belonging to the institution), H. PIOTROWSKA-KEMPISTY (616 Poland), M. NOWICKI (616 Poland), B. KEMPISTY (616 Poland, guarantor) and P. ANTOSIK (616 Poland)
Edition
Journal of biological regulators and homeostatic agents, Silva Marina, Biolife SAS, 2019, 0393-974X
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
10601 Cell biology
Country of publisher
Italy
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 1.506
RIV identification code
RIV/00216224:14110/19:00113004
Organization unit
Faculty of Medicine
UT WoS
000464697500019
Keywords in English
primary cell model; in vitro growth and development; nuclear-cytoplasmic shuttling
Tags
International impact, Reviewed
Změněno: 14/4/2020 14:25, Mgr. Tereza Miškechová
Abstract
V originále
Shuttling proteins are molecules that can facilitate transport through the nuclear envelope. A very large number of proteins are involved in this process that includes nuclear pore buildup, signal, receptor and enzyme proteins. There are many examples of proteins whose biological activity depends on nucleocytoplasmic transport. Very often they are largely responsible for the proper occurrence of cell division, maturation, development and differentiation. Thanks to the well mastered methods of in vitro cell culture, it is possible to trace the levels of protein expression and their distribution in cells. Advanced molecular techniques allow for precise determination of their displacement in time. Several studies are still being carried out, using primary cultures, to identify the factors that determine the maturation, development and differentiation of cells. In understanding of the detailed mechanisms controlling cell life, the key is not the level of expression of a specific protein, but its distribution in individual cellular compartments.