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@article{1624856,
author = {Saglio, Giuseppe and Sharf, Giora and Almeida, Antonio and Bogdanovic, Andrija and Bombaci, Felice and Cugurovic, Jelena and Deekes, Nigel and GarciaandGutierrez, Valentin and de Jong, Jan and Narbutas, Sarunas and Westerweel, Peter and Žáčková, Daniela},
article_location = {DALLAS},
article_number = {6},
doi = {http://dx.doi.org/10.1016/j.clml.2018.04.005},
keywords = {CML; CML advocates; TFR; TKIs (Tyrosine Kinase Inhibitors); Therapy discontinuation},
language = {eng},
issn = {2152-2650},
journal = {CLINICAL LYMPHOMA MYELOMA & LEUKEMIA},
note = {bez afiliace k MU},
title = {Considerations for Treatment-free Remission in Patients With Chronic Myeloid Leukemia: A Joint Patient-Physician Perspective},
url = {http://dx.doi.org/10.1016/j.clml.2018.04.005},
volume = {18},
year = {2018}
}
TY - JOUR
ID - 1624856
AU - Saglio, Giuseppe - Sharf, Giora - Almeida, Antonio - Bogdanovic, Andrija - Bombaci, Felice - Cugurovic, Jelena - Deekes, Nigel - Garcia-Gutierrez, Valentin - de Jong, Jan - Narbutas, Sarunas - Westerweel, Peter - Žáčková, Daniela
PY - 2018
TI - Considerations for Treatment-free Remission in Patients With Chronic Myeloid Leukemia: A Joint Patient-Physician Perspective
JF - CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
VL - 18
IS - 6
SP - 375-379
EP - 375-379
PB - CIG MEDIA GROUP, LP
SN - 21522650
N1 - bez afiliace k MU
KW - CML
KW - CML advocates
KW - TFR
KW - TKIs (Tyrosine Kinase Inhibitors)
KW - Therapy discontinuation
UR - http://dx.doi.org/10.1016/j.clml.2018.04.005
L2 - http://dx.doi.org/10.1016/j.clml.2018.04.005
N2 - Treatment-free remission (TFR) after discontinuation of tyrosine kinase inhibitor therapy is now an emerging treatment goal for patients with chronic myeloid leukemia, who have achieved a deep and stable response to treatment. Although guidance is now available, patients' questions regarding this progressive concept have yet to be addressed. The overall aim of this European Steering Group is a patient-centered approach that educates patients on their treatment options, including TFR, facilitates better patient-physician relationships, and meets patients' emotional and psychological needs. The present report outlines 5 key topic areas on discontinuing tyrosine kinase therapy and the implications of TFR for patient-physician consideration: what TFR is; when TFR is appropriate; which patients might and might not be eligible for TFR; and patients' considerations for discontinuing therapy, such as tyrosine kinase withdrawal syndrome, potential psychological implications, molecular recurrence, and repeat treatment. This Steering Group advocates that patients with chronic myeloid leukemia should have access to high-quality, frequent molecular monitoring and be treated in a specialist center with appropriate medical and psychological support. As patient concerns with attempting TFR become forefront in patient-physician discussions, a greater number of eligible patients might be willing to discontinue therapy.
ER -
SAGLIO, Giuseppe, Giora SHARF, Antonio ALMEIDA, Andrija BOGDANOVIC, Felice BOMBACI, Jelena CUGUROVIC, Nigel DEEKES, Valentin GARCIA-GUTIERREZ, Jan DE JONG, Sarunas NARBUTAS, Peter WESTERWEEL a Daniela ŽÁČKOVÁ. Considerations for Treatment-free Remission in Patients With Chronic Myeloid Leukemia: A Joint Patient-Physician Perspective. \textit{CLINICAL LYMPHOMA MYELOMA \&{}amp; LEUKEMIA}. DALLAS: CIG MEDIA GROUP, LP, roč.~18, č.~6, s.~375-379. ISSN~2152-2650. doi:10.1016/j.clml.2018.04.005. 2018.
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