Comparative phosphorylation map of Dishevelled 3 links phospho-signatures to biological outputs

HANÁKOVÁ, Kateřina, Ondřej BERNATÍK, Marek KRAVEC, Miroslav MICKA, Jitender KUMAR, Jakub HARNOŠ, Petra OVESNÁ, Petra PACLÍKOVÁ, Matěj RÁDSETOULAL, David POTĚŠIL, Konstantinos TRIPSIANES, Lukáš ČAJÁNEK, Zbyněk ZDRÁHAL and Vítězslav BRYJA. Comparative phosphorylation map of Dishevelled 3 links phospho-signatures to biological outputs. Cell Communication and Signaling. 2019, vol. 17, No 1, p. 1-21. ISSN 1478-811X. Available from: https://dx.doi.org/10.1186/s12964-019-0470-z.

Basic information

• Original name: Comparative phosphorylation map of Dishevelled 3 links phospho-signatures to biological outputs
• Authors: HANÁKOVÁ, Kateřina (203 Czech Republic, belonging to the institution), Ondřej BERNATÍK (203 Czech Republic, belonging to the institution), Marek KRAVEC (703 Slovakia, belonging to the institution), Miroslav MICKA (203 Czech Republic, belonging to the institution), Jitender KUMAR (356 India, belonging to the institution), Jakub HARNOŠ (203 Czech Republic, belonging to the institution), Petra OVESNÁ (203 Czech Republic, belonging to the institution), Petra PACLÍKOVÁ (203 Czech Republic, belonging to the institution), Matěj RÁDSETOULAL (203 Czech Republic, belonging to the institution), David POTĚŠIL (203 Czech Republic, belonging to the institution), Konstantinos TRIPSIANES (300 Greece, belonging to the institution), Lukáš ČAJÁNEK (203 Czech Republic, belonging to the institution), Zbyněk ZDRÁHAL (203 Czech Republic, belonging to the institution) and Vítězslav BRYJA (203 Czech Republic, guarantor, belonging to the institution).
• Edition: Cell Communication and Signaling, 2019, 1478-811X.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 10608 Biochemistry and molecular biology
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 4.344
• RIV identification code: RIV/00216224:14310/19:00108165
• Organization unit: Faculty of Science
• Doi: http://dx.doi.org/10.1186/s12964-019-0470-z
• UT WoS: 000512638800001
• Keywords in English: CK1; Dishevelled; DVL3; Kinase; Mass spectrometry; NEK2; Phosphorylation; TTBK2; Wnt
• Tags: 14110517, 14119612, CF NMR, CF PROT, podil, rivok
• Tags: International impact, Reviewed

Abstract

Dishevelled (DVL) is an essential component of the Wnt signaling cascades. Function of DVL is controlled by phosphorylation but the molecular details are missing. DVL3 contains 131 serines and threonines whose phosphorylation generates complex barcodes underlying diverse DVL3 functions.

Links

• GA18-17658S, research and development project: Name: Odhalení tajemství signální dráhy WNT analýzou struktury proteinu Dishevelled

Investor: Czech Science Foundation

• GA19-05244S, research and development project: Name: Molekulární aspekty ciliogeneze: zaměření na Tau Tubulin Kinázu 2

Investor: Czech Science Foundation

• GJ16-03269Y, research and development project: Name: Tau tubulin kináza 2 v ciliogenezi: molekulární mechanismy a funkční důsledky

Investor: Czech Science Foundation

• GX19-28347X, research and development project: Name: Molekulární a funkční analýza biologie kasein kinázy 1

Investor: Czech Science Foundation

• LQ1601, research and development project: Name: CEITEC 2020 (Acronym: CEITEC2020)

Investor: Ministry of Education, Youth and Sports of the CR