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@article{1630376, author = {Hromčík, Filip and Vokurka, Jan and Göpfert, Eduard and Faldyna, Martin and Hermanová, Markéta and Kýr, Michal and Vicenová, Monika and Izakovičová Hollá, Lydie}, article_location = {Olomouc}, article_number = {2}, doi = {http://dx.doi.org/10.5507/bp.2020.003}, keywords = {EGT approach; EGT; periodontitis; lipoxin; resolvin; pro-resolving mediators}, language = {eng}, issn = {1213-8118}, journal = {Biomedical Papers}, title = {Granulation tissue enriched by aspirin and omega-3 fatty acids in healing experimental periodontal lesion}, url = {https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-2352&fbclid=IwAR1g0vgpY79Itq4sCvVmOyPm0Hnt4_ll5VrbekN1169lRRt9oPE73iPjCz0}, volume = {165}, year = {2021} }
TY - JOUR ID - 1630376 AU - Hromčík, Filip - Vokurka, Jan - Göpfert, Eduard - Faldyna, Martin - Hermanová, Markéta - Kýr, Michal - Vicenová, Monika - Izakovičová Hollá, Lydie PY - 2021 TI - Granulation tissue enriched by aspirin and omega-3 fatty acids in healing experimental periodontal lesion JF - Biomedical Papers VL - 165 IS - 2 SP - 216-223 EP - 216-223 PB - Univerzita Palackého v Olomouci SN - 12138118 KW - EGT approach KW - EGT KW - periodontitis KW - lipoxin KW - resolvin KW - pro-resolving mediators UR - https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-2352&fbclid=IwAR1g0vgpY79Itq4sCvVmOyPm0Hnt4_ll5VrbekN1169lRRt9oPE73iPjCz0 L2 - https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-2352&fbclid=IwAR1g0vgpY79Itq4sCvVmOyPm0Hnt4_ll5VrbekN1169lRRt9oPE73iPjCz0 N2 - Aims. Granulation tissue (GT) and specialized proresolving mediators such as lipoxins and resolvins are key elements in the successful resolution of periodontitis. Aspirin triggered lipoxins and resolvins are even more powerful than their natural analogues. Their biosynthesis can be accelerated by omega3 fatty acids. The aim of this study was to evaluate the use of GT enriched by aspirin and omega‑3 fatty acids during the surgical treatment of periodontitis in an experimental animal model (rabbit). Methods. In each of 24 rabbits, two experimental periodontal defects were created. In total, 47 defects were treated with open flap debridement and one of three procedures: (1) GT extracted and soaked with aspirin and omega‑3 fatty acids (ASA+OMEGA3 group); (2) GT soaked with saline (PLACEBO group); or (3) GT left untreated (CONTROL group). Then, the GT was replaced in situ. Primary evaluated criteria were the probing pocket depth (PPD) and the clinical at‑ tachment level (CAL). Necropsies were harvested 2, 6, and 12 weeks after surgery. The samples were used for histological and molecular biological assessment. Results. A trend of greater PPD and CAL in the ASA+OMEGA3 group was observed at 6 weeks. However, there was no significant difference between them. During the observation period, tissue levels of FGF‑7, IL1β and TIMP1 showed a statistically significant decrease (P<0.05). For the other variables, the ASA+OMEGA3 group was comparable with the PLACEBO and CONTROL groups. Conclusion. This experiment did not demonstrate the superiority of the proposed approach. However, the enriched granulation tissue did not impair healing outcomes. ER -
HROMČÍK, Filip, Jan VOKURKA, Eduard GÖPFERT, Martin FALDYNA, Markéta HERMANOVÁ, Michal KÝR, Monika VICENOVÁ a Lydie IZAKOVIČOVÁ HOLLÁ. Granulation tissue enriched by aspirin and omega-3 fatty acids in healing experimental periodontal lesion. \textit{Biomedical Papers}. Olomouc: Univerzita Palackého v Olomouci, roč.~165, č.~2, s.~216-223. ISSN~1213-8118. doi:10.5507/bp.2020.003. 2021.
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