Differences in right-to-left vs left-to-right interventricular
conduction times in patients indicated to cardiac
resynchronization therapy

J 2020

Differences in right-to-left vs left-to-right interventricular conduction times in patients indicated to cardiac resynchronization therapy

POSPÍŠIL, David, Tomáš NOVOTNÝ, Jiří JARKOVSKÝ, Barbora FARKASOVÁ, Milan KOZÁK et. al.

Basic information

Original name

Differences in right-to-left vs left-to-right interventricular conduction times in patients indicated to cardiac resynchronization therapy

Authors

POSPÍŠIL, David (203 Czech Republic, guarantor, belonging to the institution), Tomáš NOVOTNÝ (203 Czech Republic, belonging to the institution), Jiří JARKOVSKÝ (203 Czech Republic, belonging to the institution), Barbora FARKASOVÁ (203 Czech Republic, belonging to the institution), Milan KOZÁK (203 Czech Republic, belonging to the institution), Lubomír KŘIVAN (203 Czech Republic, belonging to the institution), Jitka VLAŠÍNOVÁ (203 Czech Republic, belonging to the institution), Petr KALA (203 Czech Republic, belonging to the institution) and Milan SEPŠI (203 Czech Republic, belonging to the institution)

Edition

PLoS One, San Francisco, Public Library Science, 2020, 1932-6203

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.240

RIV identification code

RIV/00216224:14110/20:00115393

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1371/journal.pone.0228731

UT WoS

000535220600026

Keywords in English

ELECTRICAL DELAY; HEART-FAILURE

Abstract

V originále

Introduction Differences in conduction times from right ventricle to left ventricle and from left ventricle to right ventricle respectively were observed during biventricular devices implantation when changing pacing vector direction. In this article the phenomenon of interventricular conduction time differences is described and assessed in relationship to various clinical and electrophysiological parameters. Methods In 62 consecutive patients (9 females) interventricular conduction times between right and left ventricle in both directions were measured during cardiac resynchronization therapy device implantation procedure. Complex pacing protocol was performed. Results Investigated individuals was divided into 3 subgroups according to type of interventricular conduction pattern and statistically tested with various clinical data. Substantial differences in right-to-left vs left-to-right conduction times (> 5 ms, range 7-72 ms) were observed in 24 (39%) of all patients. They were more common in patients with dilated cardiomyopathy (20 of 38, 53%) compared to 4 (17%) of 24 patients with coronary artery disease (p = 0.011). The phenomenon occurred more often in hypertensive patients (p = 0.012). Other tested factors were nonsignificant. Conclusions There are almost no data on this topic. The occurrence of conduction difference phenomenon is quite common in dilated cardiomyopathy while it is rare in coronary artery disease. We assume the diffuse nature of the disease and the way of remodeling of myocardium play the main role. Knowledge of this phenomenon could be useful in personalized cardiac resynchronization therapy optimization.

Links

LM2018128, research and development project

Name: Český národní uzel Evropské sítě infrastruktur klinického výzkumu (Acronym: CZECRIN)

Investor: Ministry of Education, Youth and Sports of the CR

MUNI/A/1446/2019, interní kód MU

Name: Nevyřešené otázky a nové metody hodnocení elektrokardiografického signálu (Acronym: ECG2020)

Investor: Masaryk University, Category A

Citovat

POSPÍŠIL, David, Tomáš NOVOTNÝ, Jiří JARKOVSKÝ, Barbora FARKASOVÁ, Milan KOZÁK, Lubomír KŘIVAN, Jitka VLAŠÍNOVÁ, Petr KALA and Milan SEPŠI. Differences in right-to-left vs left-to-right interventricular conduction times in patients indicated to cardiac resynchronization therapy. PLoS One. San Francisco: Public Library Science, 2020, vol. 15, No 2, p. 1-8. ISSN 1932-6203. Available from: https://dx.doi.org/10.1371/journal.pone.0228731.

@article{1632520,
   author = {Pospíšil, David and Novotný, Tomáš and Jarkovský, Jiří and Farkasová, Barbora and Kozák, Milan and Křivan, Lubomír and Vlašínová, Jitka and Kala, Petr and Sepši, Milan},
   article_location = {San Francisco},
   article_number = {2},
   doi = {http://dx.doi.org/10.1371/journal.pone.0228731},
   keywords = {ELECTRICAL DELAY; HEART-FAILURE},
   language = {eng},
   issn = {1932-6203},
   journal = {PLoS One},
   title = {Differences in right-to-left vs left-to-right interventricular conduction times in patients indicated to cardiac resynchronization therapy},
   url = {https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0228731&type=printable},
   volume = {15},
   year = {2020}
}

TY  - JOUR
ID  - 1632520
AU  - Pospíšil, David - Novotný, Tomáš - Jarkovský, Jiří - Farkasová, Barbora - Kozák, Milan - Křivan, Lubomír - Vlašínová, Jitka - Kala, Petr - Sepši, Milan
PY  - 2020
TI  - Differences in right-to-left vs left-to-right interventricular conduction times in patients indicated to cardiac resynchronization therapy
JF  - PLoS One
VL  - 15
IS  - 2
SP  - 1-8
EP  - 1-8
PB  - Public Library Science
SN  - 19326203
KW  - ELECTRICAL DELAY
KW  - HEART-FAILURE
UR  - https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0228731&type=printable
L2  - https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0228731&type=printable
N2  - Introduction Differences in conduction times from right ventricle to left ventricle and from left ventricle to right ventricle respectively were observed during biventricular devices implantation when changing pacing vector direction. In this article the phenomenon of interventricular conduction time differences is described and assessed in relationship to various clinical and electrophysiological parameters. Methods In 62 consecutive patients (9 females) interventricular conduction times between right and left ventricle in both directions were measured during cardiac resynchronization therapy device implantation procedure. Complex pacing protocol was performed. Results Investigated individuals was divided into 3 subgroups according to type of interventricular conduction pattern and statistically tested with various clinical data. Substantial differences in right-to-left vs left-to-right conduction times (> 5 ms, range 7-72 ms) were observed in 24 (39%) of all patients. They were more common in patients with dilated cardiomyopathy (20 of 38, 53%) compared to 4 (17%) of 24 patients with coronary artery disease (p = 0.011). The phenomenon occurred more often in hypertensive patients (p = 0.012). Other tested factors were nonsignificant. Conclusions There are almost no data on this topic. The occurrence of conduction difference phenomenon is quite common in dilated cardiomyopathy while it is rare in coronary artery disease. We assume the diffuse nature of the disease and the way of remodeling of myocardium play the main role. Knowledge of this phenomenon could be useful in personalized cardiac resynchronization therapy optimization.
ER  -

POSPÍŠIL, David, Tomáš NOVOTNÝ, Jiří JARKOVSKÝ, Barbora FARKASOVÁ, Milan KOZÁK, Lubomír KŘIVAN, Jitka VLAŠÍNOVÁ, Petr KALA and Milan SEPŠI. Differences in right-to-left vs left-to-right interventricular conduction times in patients indicated to cardiac resynchronization therapy. \textit{PLoS One}. San Francisco: Public Library Science, 2020, vol.~15, No~2, p.~1-8. ISSN~1932-6203. Available from: https://dx.doi.org/10.1371/journal.pone.0228731.

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