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@article{1632619,
author = {Stopkova, Romana and Vinkler, David and Kuntova, Barbora and Šedo, Ondrej and Albrecht, Tomáš and Suchan, Jan and DvorakovaandHortova, Katerina and Zdráhal, Zbyněk and Stopka, Pavel},
article_location = {LAUSANNE},
article_number = {2016},
doi = {http://dx.doi.org/10.3389/fevo.2016.00047},
keywords = {lipocalin; odorant; chemical communication; Mus musculus; olfaction},
language = {eng},
issn = {2296-701X},
journal = {FRONTIERS IN ECOLOGY AND EVOLUTION},
title = {Mouse Lipocalins (MUP, OBP, LCN) Are Co-expressed in Tissues Involved in Chemical Communication},
url = {https://www.frontiersin.org/articles/10.3389/fevo.2016.00047/full},
volume = {4},
year = {2016}
}
TY - JOUR
ID - 1632619
AU - Stopkova, Romana - Vinkler, David - Kuntova, Barbora - Šedo, Ondrej - Albrecht, Tomáš - Suchan, Jan - Dvorakova-Hortova, Katerina - Zdráhal, Zbyněk - Stopka, Pavel
PY - 2016
TI - Mouse Lipocalins (MUP, OBP, LCN) Are Co-expressed in Tissues Involved in Chemical Communication
JF - FRONTIERS IN ECOLOGY AND EVOLUTION
VL - 4
IS - 2016
SP - 1-11
EP - 1-11
PB - FRONTIERS MEDIA SA
SN - 2296701X
KW - lipocalin
KW - odorant
KW - chemical communication
KW - Mus musculus
KW - olfaction
UR - https://www.frontiersin.org/articles/10.3389/fevo.2016.00047/full
L2 - https://www.frontiersin.org/articles/10.3389/fevo.2016.00047/full
N2 - Chemical communication is mediated by signal production and signal perception and in house mice (Mus musculus), both processes involve lipocalin proteins (OBP, MUP, LCN) that transport volatiles and protect them in tissues where they are produced. However, potential roles of lacrimal, nasal, and salivary lipocalins are still not well known. We aimed to determine the expression of the recently described family of odorant binding proteins (Obp), along with major urinary proteins (Mup) across different tissues in wild mice (Mus musculus) to assess the importance of these proteins based on their quantity in particular expression sites. We performed qPCR analysis of selected Mup, Lcn, Obp genes, and predicted Obp members to study their expression in selected tissues. We identified new members of the mouse odorant binding protein gene family in two subspecies, M. m. musculus and M. m. dornesticus. We show that Mup4 and Mupb from the phylogenetically older group-A are co-expressed with Obps in orofacial tissues. We also identified a sexually dimorphic pattern of female-biased Obp7 and male-biased Mup4 expression in lacrimal glands. OBPs, MUPs, and LCNs are produced in parallel, which may function to widen the spectrum of bound ligands, potentially including the degradation products of olfactory signals and/or toxic compounds. Moreover, our study demonstrates that several pheromone transporters from the lipocalin family are co-expressed in the nasal and lacrimal tissues of mice with the newly detected OBPs that further expand the already diverse mouse lipocalin family.
ER -
STOPKOVA, Romana, David VINKLER, Barbora KUNTOVA, Ondrej ŠEDO, Tomáš ALBRECHT, Jan SUCHAN, Katerina DVORAKOVA-HORTOVA, Zbyněk ZDRÁHAL and Pavel STOPKA. Mouse Lipocalins (MUP, OBP, LCN) Are Co-expressed in Tissues Involved in Chemical Communication. \textit{FRONTIERS IN ECOLOGY AND EVOLUTION}. LAUSANNE: FRONTIERS MEDIA SA, 2016, vol.~4, No~2016, p.~1-11. ISSN~2296-701X. Available from: https://dx.doi.org/10.3389/fevo.2016.00047.
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