SKOLAKOVA, P., D. RENCIUK, J. PALACKY, Daniel KRAFČÍK, Z. DVORAKOVA, I. KEJNOVSKA, K. BEDNAROVA and M. VORLICKOVA. Systematic investigation of sequence requirements for DNA i-motif formation. Nucleic acids research. Oxford: Oxford University Press, 2019, vol. 47, No 5, p. 2177-2189. ISSN 0305-1048. Available from: https://dx.doi.org/10.1093/nar/gkz046. |
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@article{1635177, author = {Skolakova, P. and Renciuk, D. and Palacky, J. and Krafčík, Daniel and Dvorakova, Z. and Kejnovska, I. and Bednarova, K. and Vorlickova, M.}, article_location = {Oxford}, article_number = {5}, doi = {http://dx.doi.org/10.1093/nar/gkz046}, keywords = {GENE-EXPRESSION; RATIONAL DESIGN; G-QUADRUPLEX; LOOP LENGTH; STABILITY; THERMODYNAMICS; KINETICS}, language = {eng}, issn = {0305-1048}, journal = {Nucleic acids research}, title = {Systematic investigation of sequence requirements for DNA i-motif formation}, url = {https://academic.oup.com/nar/article/47/5/2177/5305265}, volume = {47}, year = {2019} }
TY - JOUR ID - 1635177 AU - Skolakova, P. - Renciuk, D. - Palacky, J. - Krafčík, Daniel - Dvorakova, Z. - Kejnovska, I. - Bednarova, K. - Vorlickova, M. PY - 2019 TI - Systematic investigation of sequence requirements for DNA i-motif formation JF - Nucleic acids research VL - 47 IS - 5 SP - 2177-2189 EP - 2177-2189 PB - Oxford University Press SN - 03051048 KW - GENE-EXPRESSION KW - RATIONAL DESIGN KW - G-QUADRUPLEX KW - LOOP LENGTH KW - STABILITY KW - THERMODYNAMICS KW - KINETICS UR - https://academic.oup.com/nar/article/47/5/2177/5305265 L2 - https://academic.oup.com/nar/article/47/5/2177/5305265 N2 - The formation of intercalated motifs (iMs) secondary DNA structures based on hemiprotonated C.C+ pairs in suitable cytosine-rich DNA sequences, is reflected by typical changes in CD and UV absorption spectra. By means of spectroscopic methods, electrophoresis, chemical modifications and other procedures, we characterized iM formation and stability in sequences with different cytosine block lengths interrupted by various numbers and types of nucleotides. Particular attention was paid to the formation of iMs at pH conditions close to neutral. We identified the optimal conditions and minimal requirements for iM formation in DNA sequences, and addressed gaps and inaccurate data interpretations in existing studies to specify principles of iM formation and modes of their folding. ER -
SKOLAKOVA, P., D. RENCIUK, J. PALACKY, Daniel KRAFČÍK, Z. DVORAKOVA, I. KEJNOVSKA, K. BEDNAROVA and M. VORLICKOVA. Systematic investigation of sequence requirements for DNA i-motif formation. \textit{Nucleic acids research}. Oxford: Oxford University Press, 2019, vol.~47, No~5, p.~2177-2189. ISSN~0305-1048. Available from: https://dx.doi.org/10.1093/nar/gkz046.
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