| SKOLAKOVA, P., D. RENCIUK, J. PALACKY, Daniel KRAFČÍK, Z. DVORAKOVA, I. KEJNOVSKA, K. BEDNAROVA and M. VORLICKOVA. Systematic investigation of sequence requirements for DNA i-motif formation. Nucleic acids research. Oxford: Oxford University Press, 2019, vol. 47, No 5, p. 2177-2189. ISSN 0305-1048. Available from: https://dx.doi.org/10.1093/nar/gkz046. |
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@article{1635177,
author = {Skolakova, P. and Renciuk, D. and Palacky, J. and Krafčík, Daniel and Dvorakova, Z. and Kejnovska, I. and Bednarova, K. and Vorlickova, M.},
article_location = {Oxford},
article_number = {5},
doi = {http://dx.doi.org/10.1093/nar/gkz046},
keywords = {GENE-EXPRESSION; RATIONAL DESIGN; G-QUADRUPLEX; LOOP LENGTH; STABILITY; THERMODYNAMICS; KINETICS},
language = {eng},
issn = {0305-1048},
journal = {Nucleic acids research},
title = {Systematic investigation of sequence requirements for DNA i-motif formation},
url = {https://academic.oup.com/nar/article/47/5/2177/5305265},
volume = {47},
year = {2019}
}
TY - JOUR
ID - 1635177
AU - Skolakova, P. - Renciuk, D. - Palacky, J. - Krafčík, Daniel - Dvorakova, Z. - Kejnovska, I. - Bednarova, K. - Vorlickova, M.
PY - 2019
TI - Systematic investigation of sequence requirements for DNA i-motif formation
JF - Nucleic acids research
VL - 47
IS - 5
SP - 2177-2189
EP - 2177-2189
PB - Oxford University Press
SN - 03051048
KW - GENE-EXPRESSION
KW - RATIONAL DESIGN
KW - G-QUADRUPLEX
KW - LOOP LENGTH
KW - STABILITY
KW - THERMODYNAMICS
KW - KINETICS
UR - https://academic.oup.com/nar/article/47/5/2177/5305265
L2 - https://academic.oup.com/nar/article/47/5/2177/5305265
N2 - The formation of intercalated motifs (iMs) secondary DNA structures based on hemiprotonated C.C+ pairs in suitable cytosine-rich DNA sequences, is reflected by typical changes in CD and UV absorption spectra. By means of spectroscopic methods, electrophoresis, chemical modifications and other procedures, we characterized iM formation and stability in sequences with different cytosine block lengths interrupted by various numbers and types of nucleotides. Particular attention was paid to the formation of iMs at pH conditions close to neutral. We identified the optimal conditions and minimal requirements for iM formation in DNA sequences, and addressed gaps and inaccurate data interpretations in existing studies to specify principles of iM formation and modes of their folding.
ER -
SKOLAKOVA, P., D. RENCIUK, J. PALACKY, Daniel KRAFČÍK, Z. DVORAKOVA, I. KEJNOVSKA, K. BEDNAROVA and M. VORLICKOVA. Systematic investigation of sequence requirements for DNA i-motif formation. \textit{Nucleic acids research}. Oxford: Oxford University Press, 2019, vol.~47, No~5, p.~2177-2189. ISSN~0305-1048. Available from: https://dx.doi.org/10.1093/nar/gkz046.
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