KUSHKEVYCH, Ivan, Jiří CEJNAR, Jakub TREML, Dani DORDEVIĆ, Peter KOLLÁR and Monika VÍTĚZOVÁ. Recent Advances in Metabolic Pathways of Sulfate Reduction in Intestinal Bacteria. Cells. Basel: MDPI, vol. 9, No 3, p. 1-16. ISSN 2073-4409. doi:10.3390/cells9030698. 2020.
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Basic information
Original name Recent Advances in Metabolic Pathways of Sulfate Reduction in Intestinal Bacteria
Authors KUSHKEVYCH, Ivan (804 Ukraine, guarantor, belonging to the institution), Jiří CEJNAR (203 Czech Republic, belonging to the institution), Jakub TREML (203 Czech Republic, belonging to the institution), Dani DORDEVIĆ (203 Czech Republic), Peter KOLLÁR (203 Czech Republic, belonging to the institution) and Monika VÍTĚZOVÁ (203 Czech Republic, belonging to the institution).
Edition Cells, Basel, MDPI, 2020, 2073-4409.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10600 1.6 Biological sciences
Country of publisher Switzerland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 6.600
RIV identification code RIV/00216224:14310/20:00115417
Organization unit Faculty of Science
Doi http://dx.doi.org/10.3390/cells9030698
UT WoS 000529337400175
Keywords in English intestinal microbiota; sulfate reduction; assimilatory; sulfate-reducing bacteria; hydrogen sulfide; toxicity; cysteine biosynthesis
Tags rivok, ÚFTo, ÚMF
Tags International impact, Reviewed
Changed by Changed by: Mgr. Marie Šípková, DiS., učo 437722. Changed: 29/4/2021 15:58.
Abstract
Sulfate is present in foods, beverages, and drinking water. Its reduction and concentration in the gut depend on the intestinal microbiome activity, especially sulfate-reducing bacteria (SRB), which can be involved in inflammatory bowel disease (IBD). Assimilatory sulfate reduction (ASR) is present in all living organisms. In this process, sulfate is reduced to hydrogen sulfide and then included in cysteine and methionine biosynthesis. In contrast to assimilatory sulfate reduction, the dissimilatory process is typical for SRB. A terminal product of this metabolism pathway is hydrogen sulfide, which can be involved in gut inflammation and also causes problems in industries (due to corrosion effects). The aim of the review was to compare assimilatory and dissimilatory sulfate reduction (DSR). These processes occur in some species of intestinal bacteria (e.g., Escherichia and Desulfovibrio genera). The main attention was focused on the description of genes and their location in selected strains. Their coding expression of the enzymes is associated with anabolic processes in various intestinal bacteria. These analyzed recent advances can be important factors for proposing possibilities of metabolic pathway extension from hydrogen sulfide to cysteine in intestinal SRB. The switch from the DSR metabolic pathway to the ASR metabolic pathway is important since toxic sulfide is not produced as a final product.
Links
MUNI/A/0947/2019, interní kód MUName: Podpora výzkumné činnosti studentů Mikrobiologie a molekulární biotechnologie 4 (Acronym: SV2020)
Investor: Masaryk University, Category A
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