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@article{1635477,
author = {Kushkevych, Ivan and Cejnar, Jiří and Treml, Jakub and Dordević, Dani and Kollár, Peter and Vítězová, Monika},
article_location = {Basel},
article_number = {3},
doi = {http://dx.doi.org/10.3390/cells9030698},
keywords = {intestinal microbiota; sulfate reduction; assimilatory; sulfate-reducing bacteria; hydrogen sulfide; toxicity; cysteine biosynthesis},
language = {eng},
issn = {2073-4409},
journal = {Cells},
title = {Recent Advances in Metabolic Pathways of Sulfate Reduction in Intestinal Bacteria},
url = {https://www.mdpi.com/2073-4409/9/3/698},
volume = {9},
year = {2020}
}
TY - JOUR
ID - 1635477
AU - Kushkevych, Ivan - Cejnar, Jiří - Treml, Jakub - Dordević, Dani - Kollár, Peter - Vítězová, Monika
PY - 2020
TI - Recent Advances in Metabolic Pathways of Sulfate Reduction in Intestinal Bacteria
JF - Cells
VL - 9
IS - 3
SP - 1-16
EP - 1-16
PB - MDPI
SN - 20734409
KW - intestinal microbiota
KW - sulfate reduction
KW - assimilatory
KW - sulfate-reducing bacteria
KW - hydrogen sulfide
KW - toxicity
KW - cysteine biosynthesis
UR - https://www.mdpi.com/2073-4409/9/3/698
L2 - https://www.mdpi.com/2073-4409/9/3/698
N2 - Sulfate is present in foods, beverages, and drinking water. Its reduction and concentration in the gut depend on the intestinal microbiome activity, especially sulfate-reducing bacteria (SRB), which can be involved in inflammatory bowel disease (IBD). Assimilatory sulfate reduction (ASR) is present in all living organisms. In this process, sulfate is reduced to hydrogen sulfide and then included in cysteine and methionine biosynthesis. In contrast to assimilatory sulfate reduction, the dissimilatory process is typical for SRB. A terminal product of this metabolism pathway is hydrogen sulfide, which can be involved in gut inflammation and also causes problems in industries (due to corrosion effects). The aim of the review was to compare assimilatory and dissimilatory sulfate reduction (DSR). These processes occur in some species of intestinal bacteria (e.g., Escherichia and Desulfovibrio genera). The main attention was focused on the description of genes and their location in selected strains. Their coding expression of the enzymes is associated with anabolic processes in various intestinal bacteria. These analyzed recent advances can be important factors for proposing possibilities of metabolic pathway extension from hydrogen sulfide to cysteine in intestinal SRB. The switch from the DSR metabolic pathway to the ASR metabolic pathway is important since toxic sulfide is not produced as a final product.
ER -
KUSHKEVYCH, Ivan, Jiří CEJNAR, Jakub TREML, Dani DORDEVI$\backslash$'C, Peter KOLLÁR a Monika VÍTĚZOVÁ. Recent Advances in Metabolic Pathways of Sulfate Reduction in Intestinal Bacteria. \textit{Cells}. Basel: MDPI, roč.~9, č.~3, s.~1-16. ISSN~2073-4409. doi:10.3390/cells9030698. 2020.
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