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@article{1635477, author = {Kushkevych, Ivan and Cejnar, Jiří and Treml, Jakub and Dordević, Dani and Kollár, Peter and Vítězová, Monika}, article_location = {Basel}, article_number = {3}, doi = {http://dx.doi.org/10.3390/cells9030698}, keywords = {intestinal microbiota; sulfate reduction; assimilatory; sulfate-reducing bacteria; hydrogen sulfide; toxicity; cysteine biosynthesis}, language = {eng}, issn = {2073-4409}, journal = {Cells}, title = {Recent Advances in Metabolic Pathways of Sulfate Reduction in Intestinal Bacteria}, url = {https://www.mdpi.com/2073-4409/9/3/698}, volume = {9}, year = {2020} }
TY - JOUR ID - 1635477 AU - Kushkevych, Ivan - Cejnar, Jiří - Treml, Jakub - Dordević, Dani - Kollár, Peter - Vítězová, Monika PY - 2020 TI - Recent Advances in Metabolic Pathways of Sulfate Reduction in Intestinal Bacteria JF - Cells VL - 9 IS - 3 SP - 1-16 EP - 1-16 PB - MDPI SN - 20734409 KW - intestinal microbiota KW - sulfate reduction KW - assimilatory KW - sulfate-reducing bacteria KW - hydrogen sulfide KW - toxicity KW - cysteine biosynthesis UR - https://www.mdpi.com/2073-4409/9/3/698 L2 - https://www.mdpi.com/2073-4409/9/3/698 N2 - Sulfate is present in foods, beverages, and drinking water. Its reduction and concentration in the gut depend on the intestinal microbiome activity, especially sulfate-reducing bacteria (SRB), which can be involved in inflammatory bowel disease (IBD). Assimilatory sulfate reduction (ASR) is present in all living organisms. In this process, sulfate is reduced to hydrogen sulfide and then included in cysteine and methionine biosynthesis. In contrast to assimilatory sulfate reduction, the dissimilatory process is typical for SRB. A terminal product of this metabolism pathway is hydrogen sulfide, which can be involved in gut inflammation and also causes problems in industries (due to corrosion effects). The aim of the review was to compare assimilatory and dissimilatory sulfate reduction (DSR). These processes occur in some species of intestinal bacteria (e.g., Escherichia and Desulfovibrio genera). The main attention was focused on the description of genes and their location in selected strains. Their coding expression of the enzymes is associated with anabolic processes in various intestinal bacteria. These analyzed recent advances can be important factors for proposing possibilities of metabolic pathway extension from hydrogen sulfide to cysteine in intestinal SRB. The switch from the DSR metabolic pathway to the ASR metabolic pathway is important since toxic sulfide is not produced as a final product. ER -
KUSHKEVYCH, Ivan, Jiří CEJNAR, Jakub TREML, Dani DORDEVI$\backslash$'C, Peter KOLLÁR and Monika VÍTĚZOVÁ. Recent Advances in Metabolic Pathways of Sulfate Reduction in Intestinal Bacteria. \textit{Cells}. Basel: MDPI, 2020, vol.~9, No~3, p.~1-16. ISSN~2073-4409. Available from: https://dx.doi.org/10.3390/cells9030698.
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