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@article{1636816, author = {Panwar, U. and Chandra, I. and Chandrabose, Selvaraj and Singh, S.K.}, article_location = {Sharjah}, article_number = {31}, doi = {http://dx.doi.org/10.2174/1381612825666190911160244}, keywords = {AIDS; anti-HIV; biological targets; computational drug discovery; drugs; HIV-1 life cycle; virtual screening}, language = {eng}, issn = {1381-6128}, journal = {Current Pharmaceutical Design}, title = {Current Computational Approaches for the Development of Anti-HIV Inhibitors: An Overview}, url = {http://dx.doi.org/10.2174/1381612825666190911160244}, volume = {25}, year = {2019} }
TY - JOUR ID - 1636816 AU - Panwar, U. - Chandra, I. - Chandrabose, Selvaraj - Singh, S.K. PY - 2019 TI - Current Computational Approaches for the Development of Anti-HIV Inhibitors: An Overview JF - Current Pharmaceutical Design VL - 25 IS - 31 SP - 3390-3405 EP - 3390-3405 PB - Bentham Science Publishers SN - 13816128 KW - AIDS KW - anti-HIV KW - biological targets KW - computational drug discovery KW - drugs KW - HIV-1 life cycle KW - virtual screening UR - http://dx.doi.org/10.2174/1381612825666190911160244 L2 - http://dx.doi.org/10.2174/1381612825666190911160244 N2 - Background: Today, HIV-1 infection has become an extensive problem to public health and a greater challenge to all working researchers throughout the world. Since the beginning of HIV-1 virus, several antiviral therapeutic agents have been developed at various stages to combat HIV-1 infection. But, the many of antiviral drugs are on the platform of drug resistance and toxicology issues, needs an urgent constructive investigation for the development of productive and protective therapeutics to make an improvement of individual life suffering with viral infection. As developing a novel agent is very costly, challenging and time taking route in the recent times. Methods: The review summarized about the modern approaches of computational aided drug discovery to developing a novel inhibitor within a short period of time and less cost. Results: The outcome suggests on the premise of reported information that the computational drug discovery is a powerful technology to design a defensive and fruitful therapeutic agents to combat HIV-1 infection and recover the lifespan of suffering one. Conclusion: Based on survey of the reported information, we concluded that the current computational approaches is highly supportive in the progress of drug discovery and controlling the viral infection. ER -
PANWAR, U., I. CHANDRA, Selvaraj CHANDRABOSE and S.K. SINGH. Current Computational Approaches for the Development of Anti-HIV Inhibitors: An Overview. \textit{Current Pharmaceutical Design}. Sharjah: Bentham Science Publishers, 2019, vol.~25, No~31, p.~3390-3405. ISSN~1381-6128. Available from: https://dx.doi.org/10.2174/1381612825666190911160244.
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