BENDÍČKOVÁ, Kamila, Federico TIDU, Marco DE ZUANI, Marcela HORTOVÁ KOHOUTKOVÁ, Ivana ANDREJČINOVÁ, Antonio POMPEIANO, Silvie BĚLÁŠKOVÁ, Giancarlo FORTE, Teresa ZELANTE and Jan FRIČ. Calcineurin inhibitors reduce NFAT-dependent expression of antifungal pentraxin-3 by human monocytes. Journal of Leukocyte Biology. New York: Society for Leukocyte Biology, 2020, vol. 107, No 3, p. 497-508. ISSN 0741-5400. Available from: https://dx.doi.org/10.1002/JLB.4VMA0318-138R. |
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@article{1637457, author = {Bendíčková, Kamila and Tidu, Federico and De Zuani, Marco and Hortová Kohoutková, Marcela and Andrejčinová, Ivana and Pompeiano, Antonio and Bělášková, Silvie and Forte, Giancarlo and Zelante, Teresa and Frič, Jan}, article_location = {New York}, article_number = {3}, doi = {http://dx.doi.org/10.1002/JLB.4VMA0318-138R}, keywords = {antifungal response; cyclosporine A; pattern recognition receptor signaling; Tacrolimus}, language = {eng}, issn = {0741-5400}, journal = {Journal of Leukocyte Biology}, title = {Calcineurin inhibitors reduce NFAT-dependent expression of antifungal pentraxin-3 by human monocytes}, url = {http://dx.doi.org/10.1002/JLB.4VMA0318-138R}, volume = {107}, year = {2020} }
TY - JOUR ID - 1637457 AU - Bendíčková, Kamila - Tidu, Federico - De Zuani, Marco - Hortová Kohoutková, Marcela - Andrejčinová, Ivana - Pompeiano, Antonio - Bělášková, Silvie - Forte, Giancarlo - Zelante, Teresa - Frič, Jan PY - 2020 TI - Calcineurin inhibitors reduce NFAT-dependent expression of antifungal pentraxin-3 by human monocytes JF - Journal of Leukocyte Biology VL - 107 IS - 3 SP - 497-508 EP - 497-508 PB - Society for Leukocyte Biology SN - 07415400 KW - antifungal response KW - cyclosporine A KW - pattern recognition receptor signaling KW - Tacrolimus UR - http://dx.doi.org/10.1002/JLB.4VMA0318-138R L2 - http://dx.doi.org/10.1002/JLB.4VMA0318-138R N2 - Calcineurin (CN) inhibitors are effective clinical immunosuppressants but leave patients vulnerable to potentially fatal fungal infections. This study tested the hypothesis that CN inhibition interferes with antifungal immune defenses mediated by monocytes. We showed that NFAT is expressed by human monocytes, and is activated by exposure to fungal ligands. We confirmed that NFAT translocation potently activated target gene transcription using a human monocytic reporter cell line. Inhibition of CN-NFAT by cyclosporine A significantly reduced monocyte production of TNF-alpha, IL-10, and MCP-1 proteins in response to pattern recognition receptor ligands as well as to Aspergillus fumigatus conidia. Moreover, we revealed that human monocytes express the antifungal protein pentraxin-3 under control of NFAT. In conclusion, clinical CN inhibitors have the potential to interfere with the novel NFAT-dependent pentraxin-3 pathway as well as antifungal cytokine production in human monocytes, thereby impeding monocyte-mediated defenses against fungal infection in immune-suppressed patients. ER -
BENDÍČKOVÁ, Kamila, Federico TIDU, Marco DE ZUANI, Marcela HORTOVÁ KOHOUTKOVÁ, Ivana ANDREJČINOVÁ, Antonio POMPEIANO, Silvie BĚLÁŠKOVÁ, Giancarlo FORTE, Teresa ZELANTE and Jan FRIČ. Calcineurin inhibitors reduce NFAT-dependent expression of antifungal pentraxin-3 by human monocytes. \textit{Journal of Leukocyte Biology}. New York: Society for Leukocyte Biology, 2020, vol.~107, No~3, p.~497-508. ISSN~0741-5400. Available from: https://dx.doi.org/10.1002/JLB.4VMA0318-138R.
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