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@article{1637596,
author = {Slezáková, Simona and Bořilová Linhartová, Petra and Bartova, Jirina and Petanova, Jitka and Kuklinek, Pavel and Fassmann, Antonín and Dušek, Ladislav and Izakovičová Hollá, Lydie},
article_location = {HOBOKEN},
article_number = {3},
doi = {http://dx.doi.org/10.1111/jop.12993},
keywords = {case-control study; matrix metalloproteinase; polymorphism; recurrent aphthous stomatitis},
language = {eng},
issn = {0904-2512},
journal = {JOURNAL OF ORAL PATHOLOGY & MEDICINE},
title = {Gene variability in matrix metalloproteinases in patients with recurrent aphthous stomatitis},
url = {http://dx.doi.org/10.1111/jop.12993},
volume = {49},
year = {2020}
}
TY - JOUR
ID - 1637596
AU - Slezáková, Simona - Bořilová Linhartová, Petra - Bartova, Jirina - Petanova, Jitka - Kuklinek, Pavel - Fassmann, Antonín - Dušek, Ladislav - Izakovičová Hollá, Lydie
PY - 2020
TI - Gene variability in matrix metalloproteinases in patients with recurrent aphthous stomatitis
JF - JOURNAL OF ORAL PATHOLOGY & MEDICINE
VL - 49
IS - 3
SP - 271-277
EP - 271-277
PB - WILEY
SN - 09042512
KW - case-control study
KW - matrix metalloproteinase
KW - polymorphism
KW - recurrent aphthous stomatitis
UR - http://dx.doi.org/10.1111/jop.12993
L2 - http://dx.doi.org/10.1111/jop.12993
N2 - Background The development of recurrent aphthous stomatitis (RAS), inflammatory disease of oral mucosa, is influenced by both environmental and genetic factors. The aim of this study was to investigate polymorphisms located in seven genes coding different types of matrix metalloproteinases (MMPs)-collagenases (MMP1, MMP8, and MMP13), gelatinases (MMP2 and MMP9), stromelysin (MMP3), and membrane-type metalloproteinase (MMP16) in patients with RAS and healthy controls. Methods Totally, 223 subjects were included in this case-control study and their detailed anamnestic, clinical, and laboratory parameters were recorded. Seventy-seven patients with RAS and 146 controls were genotyped for seventeen polymorphisms in the MMPs genes using the real-time polymerase chain reaction (PCR) or PCR with restriction analysis. Results Allele, genotype, and haplotype frequencies of the studied polymorphisms between RAS patients and controls were similar, except for allele distributions of MMP1 rs1144393, MMP9 rs3918242, and MMP16 rs10429371, which were different between patients with RAS and healthy controls (P = .023, P = .049 and P = .025, all P-corr > 0.05, respectively). Moreover, the comparison of genotype frequencies (TT vs CC + CT) of the MMP16 rs10429371 variant showed a marginally significant difference between RAS patients and controls (P = .05, P-corr > 0.05, OR = 1.68, 95% CI = 0.95-2.98). Conclusions No significant relationship between investigated polymorphisms in seven MMPs genes and RAS development in the Czech population was observed in this study.
ER -
SLEZÁKOVÁ, Simona, Petra BOŘILOVÁ LINHARTOVÁ, Jirina BARTOVA, Jitka PETANOVA, Pavel KUKLINEK, Antonín FASSMANN, Ladislav DUŠEK and Lydie IZAKOVIČOVÁ HOLLÁ. Gene variability in matrix metalloproteinases in patients with recurrent aphthous stomatitis. \textit{JOURNAL OF ORAL PATHOLOGY \&{}amp; MEDICINE}. HOBOKEN: WILEY, 2020, vol.~49, No~3, p.~271-277. ISSN~0904-2512. Available from: https://dx.doi.org/10.1111/jop.12993.
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