BRAT, Kristián, Miloš CHOBOLA, Pavel HOMOLKA, Michaela HEROUTOVÁ, Michal BENEJ, Ladislav MITÁŠ, Lyle J. OLSON and Ivan ČUNDRLE. Poor ventilatory efficiency during exercise may predict prolonged air leak after pulmonary lobectomy. Interactive CardioVascular and Thoracic Surgery. OXFORD: OXFORD UNIV PRESS, 2020, vol. 30, No 2, p. 269-272. ISSN 1569-9293. Available from: https://dx.doi.org/10.1093/icvts/ivz255.
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Basic information
Original name Poor ventilatory efficiency during exercise may predict prolonged air leak after pulmonary lobectomy
Authors BRAT, Kristián (703 Slovakia, belonging to the institution), Miloš CHOBOLA (203 Czech Republic, belonging to the institution), Pavel HOMOLKA (203 Czech Republic, belonging to the institution), Michaela HEROUTOVÁ (203 Czech Republic), Michal BENEJ (703 Slovakia, belonging to the institution), Ladislav MITÁŠ (203 Czech Republic, belonging to the institution), Lyle J. OLSON (840 United States of America) and Ivan ČUNDRLE (203 Czech Republic, belonging to the institution).
Edition Interactive CardioVascular and Thoracic Surgery, OXFORD, OXFORD UNIV PRESS, 2020, 1569-9293.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30203 Respiratory systems
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 1.905
RIV identification code RIV/00216224:14110/20:00115432
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1093/icvts/ivz255
UT WoS 000517789800011
Keywords in English V-E/VCO2 slope; Prolonged air leak; Postoperative complications; Anatomical lung resection
Tags 14110118, 14110120, 14110122, 14110215, 14110223, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 20/3/2020 10:14.
Abstract
Poor ventilatory efficiency, defined as the increase in minute ventilation relative to carbon dioxide production during exercise (V-E/VCO2 slope), may be associated with dynamic hyperinflation and thereby promote the development of prolonged air leak (PAL) after lung resection. Consecutive lung lobectomy candidates (n = 96) were recruited for this prospective two-centre study. All subjects underwent pulmonary function tests and cardiopulmonary exercise testing prior to surgery. PAL was defined as the presence of air leaks from the chest tube on the 5th postoperative day and developed in 28 (29%) subjects. Subjects with PAL were not different in terms of age, sex, American Society of Anesthesiologists class, type of surgery (thoracotomy/video-assisted thoracoscopic surgery) and site of surgery (right/left lung; upper/lower lobes). Subjects with PAL had more frequent pleural adhesions (50% vs 21%; P = 0.006) and steeper V-E/VCO2 slope (35 +/- 7 vs 30 +/- 5; P = 0.001). Stepwise logistic regression showed that only the presence of pleural adhesions [odds ratio (OR) 3.9, 95% confidence interval (CI) 1.4-10.9; P = 0.008] and V-E/VCO2 slope (OR 1.1, 95% CI 1.0-1.2; P = 0.003) were independently associated with PAL (AUC 0.74, 95% CI 0.62-0.86). We conclude that a high V-E/VCO2 slope during exercise may be helpful in identifying patients at greater risk for the development of PAL after lung lobectomy.
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